Medications

Question 1

Psych Meds

Specific SSRI Drugs

Answer 1

Fluoxetine
Citalopram
Paroxetine
Sertraline
Fluvoxamine

Question 2

Psych Meds

SSRI Mechanism of Action

Answer 2

Increase serotonin concentration by inhibiting the re-uptake of serotonin.

Question 3

Psych Meds

SSRI Side Effects

Answer 3

Headache, hyponatraemia, anorexia, nausea, indigestion, sexual dysfunction.
Anxiety/agitation for first 1-2 weeks
Suicidal ideation

Question 4

Psych Meds

Specific SNRI Drugs

Answer 4

Venlafaxine

Duloxetine

Question 5

Psych Meds

SNRI Mechanism of Action

Answer 5

Increase NA concentration by inhibiting the re-uptake of NA

Question 6

Psych Meds

SNRI Side Effects

Answer 6

Headache, anorexia, nausea, indigestion, sexual dysfunction. HTN/hypotension
Cardiotoxic in overdose

Question 7

Psych Meds

Specific NaSSA Drugs

Answer 7

Mirtazapine

Question 8

Psych Meds

NaSSA Mechanism of Action

Answer 8

NA and Specific Serotonin Antidepressant.

It acts centrally to increase release of NA and specific serotonin

Question 9

Psych Meds

NaSSA Side Effects

Answer 9

Dry mouth, drowsiness and weight gain

Histamine agonist
Moderate adrenergic and muscarinic antagonist

Question 10

Psych Meds

Specific TCA Drugs

Answer 10

Dothiepin
Imipramine
Amitriptyline
Lofepramine

Question 11

Psych Meds

TCA Mechanism of Action

Answer 11

Inhibits NA (and some serotonin) re-uptake

Question 12

Psych Meds

TCA Side Effects

Answer 12

Anticholinergic
- (dry mouth, urinary retention, confusion)
Antiadrenergic
- (Hypotension and impotence)
Cardiac Arrhythmias
Seizures

Question 13

Psych Meds

Specific MAOI Drugs

Answer 13

Tranylcypromine

Phenelzine

Question 14

Psych Meds

MAOI Mechanism of Action

Answer 14

Increases neurone excitability by inhibiting the uptake of neurotransmitters.

Question 15

Psych Meds

MAOI Side Effects

Answer 15

Anticholinergic
- (dry mouth, urinary retention, confusion)
Antiadrenergic
- (Hypotension and impotence)
Tyramine Reaction
- Can cause fatal syndrome of HTN and throbbing headaches.
- From cheese and red wine

Question 16

Psych Meds

SSRIs for Breast Feeding Mothers

Answer 16

Sertralline

Question 17

Psych Meds

Types of Antidepressants

Answer 17

1st Line
- SSRIs
- SNRIs
- NaSSAs
2nd Line
- TCA
- MAOI

Question 18

Psych Meds

Types of Antipsychotics

Answer 18

Typical/First Generation

Atypical/Second Generation

Question 19

Psych Meds

Specific Typical Antipsychotics

Answer 19

Chlorpromazine
Haloperidol
Zuclopenthixol

Question 20

Psych Meds

Typical Antipsychotic Mechanism of Action

Answer 20

DA-receptor blocker, but also block cholinergic, adrenergic and histamine receptors

Question 21

Psych Meds

Specific Atypical Antipsychotics

Answer 21

Risperidone
Olanzapine
Quetiapine
Aripiprazole
Ziprazidone
Amisulpride
Paliperidone
Clozapine - 'Atypical' Atypical

Question 22

Psych Meds

Atypical Antipsychotic Mechanism of Action

Answer 22

Block 5HT2A <= D2 DA receptors.
Reduced efficacy on other receptors
Thus decreased EPS and increased metabolic syndrome than Typicals.

Question 23

Psych Meds

Efficacy of Typical and Atypical Antipsychotics

Answer 23

Positive Symptoms
- All moderate
Treatment Resistance
- No except clozapine does
Negative Symptoms & Cognitive Symptoms
- Limited except for limited-moderate for clozapine

Question 24

Psych Meds

Side Effects of Typical and Atypical Antipsychotics

Answer 24

Sedation
Weight Gain
Motor (including EPS)
Other
- Prolactin (typicals and respiradone)
- Clozapine

Question 25

# Psych Meds Dexamphetamine Description

Answer 25

- Potent Psychostimulant - Short-acting - Promotes release of catecholamines (NA and DA)

Question 26

# Psych Meds Methyphenidate Description

Answer 26

- Psychostimulant - Trade name - Ritalin - Long-acting - Increases DA

Question 27

# Psych Meds Types of Anticholinesterases

Answer 27

Donepezil Rivastigmine Galantamine

Question 28

# Psych Meds Antipsychotic Motor Side Effect Frequency

Answer 28

- Typical - Common - Atypical - Less common - Clozapine - Rare

Question 29

# Psych Meds Antipsychotic Sedation Side Effect Frequency

Answer 29

Sedation - Typical - Less common - Atypical - Less common - Clozapine - Common

Question 30

# Psych Meds Clozapine Side Effect Profile

Answer 30

- Agranulocytosis - Seizures - Myocarditis

Question 31

# Psych Meds Drug-Induced EPS Treatment

Answer 31

- Neuroleptic-induced EPS -> Anticholinergic - Akathisia -> Beta blockers or benzodiazepines - Commonly used -> anticholinergic (benztropine)

Question 32

# Psych Meds Types of Mood Stabilisers

Answer 32

Lithium Antiepileptics - Valproate - Lamotrigine - Carbamazepine Atypical Antipsychotics - Olanzapine

Question 33

# Psych Meds Lithium Mechanism of Action

Answer 33

Complex inhibition of signal pathways

Question 34

# Psych Meds Lithium Side Effects

Answer 34

Hypothyroidism, fine tremor, polyuria, polydipsia, weight gain, renal impairment, teratogen, cardiac defects

Question 35

# Psych Meds Valproate Mechanism of Action

Answer 35

Causes GABA increase and blocks Na Channels

Question 36

# Psych Meds Valproate Side Effects

Answer 36

Weight gain, sedation, NTD

Question 37

# Psych Meds Lamotrigine Mechanism of Action

Answer 37

Inactivates Na Channels

Question 38

# Psych Meds Lamotrigine Side Effects

Answer 38

Dizziness, sedation, skin rashes

Question 39

# Psych Meds Carbamazepine Mechanism of Action

Answer 39

Inactivates Na Channels

Question 40

# Psych Meds Carbamazepine Side Effects

Answer 40

Sedation, ataxia, blurred vision, water retention, hypersensitivity reactions, leucopenia, interacts with OCP (oral contraceptive pill)