Medications Flashcards
(26 cards)
Actinomycin D
Anti cancer
Intercalated between G-C bases
Inhibits DNA replication and transcription
(RNA synthesis)
(Has “IN” in word)
Acyclovir
Phosphorylation by viral thymidine kinase
Inhibits viral polymerase (viral replication)
Herpes/varicella zoster
Alpha-amanitin toxin (phalloides)
Toxin
Inhibitor of RNA polymerase II
(Eukaryotes)
No mRNA formed
Treatment:
- GI decontamination
- penicillin
- liver transplant
Azidothymine (AZT) zidovudine
Viral reverse transcriptase
Inhibitor of viral replication
Treats:
-HIV
Caffeine
Inhibits phophodiaterase
Camptothecin
Anti cancer
Inhibits topoisomerase I (eukaryotes)
(One O)
Chloramphenicol
Antibiotic
Prevents elongation Inhibits peptidyltransferase (prokaryotes)
Ciprofloxacin/Nalidixic acid
Inhibits bacteria DNA gyrase (topoisomerase II) = positive supercoiling
Disrupts DNA replication and transcription
Treats:
- respiratory infections
- UTI
- Anthrax
Cycloheximide
Antibiotic
Prevents elongation of translation
Inhibits eukaryotic peptidyltransferase
Diphtheria
Toxin
Inactivated eukaryotic EF-2
Prevents translocation
Tetracycline
Antibiotic
Blocks access to A site
Preventing elongation if translation (prokaryotes)
Tenofovir
Competes w deoxy-ATP For incorporation
Viral reverse transcriptase
Inhibits of viral replication
Treats:
-HIV
Streptomycin
Distorts initiation of translation (prokaryotes)
Rifamycin
Blocks first phosodiester bond by binding PROKARYOTE RNA POLYMERASE
Inhibiting initiation of transcription
Treats:
TB
Puromycin
Antibiotic
Blocks elongation
Premature translation termination (PROKARYOTES AND EUKARYOTES)
Erythromycin
Blocks translocation
Preventing elongation
(PROKARYOTES)
Etoposide
Anti cancer
Inhibits topoisomerase II
EUKARYOTES
Novobiocin
Antibiotic
Inhibits DNA gyrase
(PROKARYOTES)
Treats:
-staph infection
Allopurinol
Inhibits xanthine oxidase
Treatment:
-gout
5-fluorouracil
Anti cancer
Inhibits thymidylate kinase = synthesis of thymine
Theophylline
Inhibits phosphodiesterase
Cystosine arabinoside (cytarabine)
Inhibits human DNA polymerase from steric strain
Inhibits DBA replication
Treatment:
-leukemia
Adenosine arabinoside (vidarabine)
Inhibits viral DNA polymerase
Treats
-leukemia
5-aka-2’-deoxycytidine (decitabine)-5-azacytidine
More transcription
DNA methyl-transferase (methyl group cannot be added to nitrogen)
