Medications and Doses

Question 1

Acetaminophen

Answer 1

Premedication - Hypersensitivity reactions
500-1000mg PO x 1, 30-60 mins prior to start of mAb infusion

Question 2

Aprepitant

Answer 2

Prevention of CINV
Day 1- 130 mg IV x1 or 125 mg PO, 30-60 mins prior to start of chemotherapy,
If PO is given on Day 1, then on Days 2 and 3- 80 mg POx1, 30-60 mins prior to the start of chemotherapy

Question 3

Diphenhydramine

Answer 3

Premedication - hypersensitivity reactions
25-50 mg IV x1, 30-60 mins prior to start of mAb infusion

Question 4

Diphenhydramine

Answer 4

Treatment for infusion-related reactions
50 mg IV x1, administer immediately by IV push. May repeat 50 mg IV Q6H PRN symptoms of reactions

Question 5

Dexamethasone

Answer 5

Premedication - hypersensitivity reactions
8-12mg IV or PO x1, 30-60 mins prior to start of mAb infusion

Question 6

Dexamethasone

Answer 6

Prevention of CINV
Day 1: 12mg IV/PO x 1, 30-60 mins prior to start of chemotherapy
If indicated: days 2-4: 8mg IV/PO x 1, 30-60 mins prior to start of chemotherapy

Question 7

Epinephrine

Answer 7

Treatment of infusion-related reactions (anaphylaxis)
0.3 mg IM x 1, repeat as needed

Question 8

Hydrocortisone

Answer 8

Treatment for infusion-related reactions
100 mg IV x 1, administer immediately by IV push; may repeat 50 mg IV Q6H PRN symptoms of reaction.

Question 9

Lorazepam

Answer 9

Treatment of anxiety-related CINV
0.5-1mg PO Q6H PRN N/V

Question 10

Olanzapine

Answer 10

Prevention of CINV (acute/delayed)
Day 1: 5-10 mg PO x 1, 30-60 mins prior to start of chemotherapy
If indicated, Days 2-4: 5-10 mg PO x1, 30-60 mins prior to start of chemotherapy

Question 11

Ondansetron

Answer 11

Prevention of CINV
Day 1: 8 mg IV x 1, 30-60 mins prior to start of chemotherapy
If indicated, Days 2-4: 8mg IV x 1, 30-60 mins prior to start of chemotherapy

Question 12

Ondansetron

Answer 12

Treatment of CINV
4-8mg PO Q8H PRN CINV

Question 13

Filgrastim

Answer 13

Treatment/prevention of neutropenia
5mcg/kg SQ or IV once daily 24 hrs after the last chemotherapy as indicated per protocol for prevention or treatment of neutropenia

Question 14

Peg-filgrastim

Answer 14

Prevention of neutropenia
6 mg SC x1 per cycle. Administer 24 hrs after the last chemotherapy and > 14 days before the next cycle

Question 15

Sargramostim

Answer 15

Treatment of neutropenia (2nd line)
250mcg/m2 SC or IV once daily 24 hrs after the last chemotherapy as indicated per protocol for prevention or treatment of neutropenia