MEDICINAL CHEMISTRY Flashcards
(20 cards)
OPIATE RECEPTOR
mu ,kappa ,sigma ,delta ,epislon
endogenous peptides
enkephalin
endorphine
dynorphine
Classification of sympathomimetic
direct acting
indirect acting
mixed acting
classification of direct acting sympathomimetics
endogenous catecholamines
alpha agonist
beta agonist
dual alpha and beta agonist/antagonist
examples of endogenous catecholamines
dopamine
epinephrine
norepinephrine
examples of alpha agonist
phenylethanolamines
aryl imidazoline
methyldopa
aminoimidazoline
examples of beta agonist
isoprenaline
resorcinol bronchodilators (terbutaline , metaproterenol)
albuterol
salmeterol
dual alpha and beta agonist/antagonist
dobutamine
indirect acting sympathomimetics
pseudoephedrine
amphetamine
methamphetamine
mixed acting sympathomimetic
ephedrine
location of nicotinic receptors
NM -present in skeletal muscles endplate
NN -present in ganglionic cells , spinal cord ,adrenal medullary cells , certain area of the brain
stimulants of nicotinic receptors
NM - phenyl trimethyl ammonium
NN- dimethyl phenyl piperazine
nicotinic receptor blockers
NM - tubocurarine
NN -hexamethonium
muscarinic receptor blockers /antagonist
atropine
prototype agonist of muscarinic receptor
muscarine ;its obtained from amantia muscaria
location of muscarinic receptors
M1 -nervous system , gastric gland
M2 - heart , smooth muscles
M3 - smooth muscles of blood vessels and lungs ,glands
M4 - CNS ,heart
M5 -CNS
classification of parasympathomimetic agents
DIRECT ACTING
1 choline esters
2 cholinomimetic alkaloids -natural alkaloids
-synthetic alkaloids
INDIRECT ACTING
1 reversible
2 irreversible
examples of choline esters
carbachol chloride
acetylcholine chloride
methacholine chloride
bethanechol chloride
examples of natural alkaloids
pilocarpine
muscarine
arecoline
examples of synthetic alkaloids
aceclidine
oxotremorine
