Flashcards in Medicine Deck (24):
Which vitamins are deplete within year?
B12 and A
Which vitamins deplete after weeks?
Folates and B1
What is thiamine pyrophosphate responsible for?
- decarboxylation of acetyl coA in mitichodria
- decarb of alpha ketoacids in kerbs cycle
Has a role in peripheral nervous conduction.
Cereal and legumes.
Pork and beef meat.
Deficiency B1 leads to?
- inability to metabolize glucose for nerves conduction.
- increase lactic and pyruvic acids which lead to vasodilation and increase cardiac output.
Causes of deficiency?
Chronic illnesses as Cancer
B1 clinical features (disease)?
1. peripheral neuropathy:
Sensory and motor pain and parasthesia
2.Cerebral involvement :
Korsakoff syndrome :
loss of new memory
high output failure
Treatment or diagnosis of b1 deficiency?
Levels of thiamine in blood
100mg/d parentral for 7 days then orally till improved
Clinical manifestations of B2 deficiency?
1. Mucocutaneous lesion
red inflamed tongue
2. Seborrhoeic dermatitis
(face around the nose)
Diagnoses and treatment of b2 deficiency?
serum or urinary level
Riboflavin 10 mg daily
Forms of Vitamin B three?
Oxidative functions in production of energy and DNA repair
How can it be synthesized?
Clinical manifestation of B3 deficiency?
Pellagra: dermatitis dementia diarrhea
Diagnosis and treatment of B3 deficiency?
Urinary 2 pyridone and 2 methyl nicotinamide
Treatment Nicotinamide 300 mg daily by mouth
Forms of B6?
Functions of B6?
cofactor of many enzymes involved in the metabolism of many amino acids.
Vitamine metabolism as niacin
Which drugs cause B6 deficiency?
Clinical manifestations of B6 deficiency?
1. mucosal changes
2. The peripheral neuropathy
Treatment of B6 deficiency?
100 mg daily should not be exceeded.
What is the function of B 12?
Cofactor for activation of folate
What causes B12 deficiency?
1. Low dietary intake, Vegans
2. Impaired absorption
Stomach : Pernicious anaemia Gastrectomy
Congenital deficiency of intrinsic factor
Small bowel: ileal disease or resection Bacterial overgrowth
Clinical features of b12 deficiency?
glossitis and angular stomatitis.
The neurological changes
subacute combined degeneration of the spinal cord
psychiatric problems depression
symmetrical paraesthesiae in the fingers and toes
subacute combined degeneration
( posterior, lateral columns of the spinal cord)
loss of vibration sense and proprioception
Paraplegia may result.