Medicines Design - Blag Flashcards Preview

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Flashcards in Medicines Design - Blag Deck (8)
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1
Q

What is Exenatide?

A

A GLP-1 agonist

Injected SC

Side effects are of benefit to the patient!!

  • Blocks pancereatic B cell apoptosis, and stimulates synthesis
  • Promtotes satiety –> So can help people lose weight
2
Q

What is the difference between a ‘Clean Drug’ and a ‘Dirty Drug’?

A

Clean –> Binds to one target site

Dirty –> Binds to several sites

So has many side effects…..which can be useful occasionally!!

3
Q

Who shouldn’t take Aspirin?

A

Those who are prone to stomach ulcers

Those on other NSAIDs (as promotes the above)

4
Q

How did is Vitamin D formed?

A

Cholesterol is dehydrogeneated (oxidised) with skin P450s –> adding a double bond between carbons 7 and 8

5
Q

What is Vitamin D used for?

A

Osteoporosis –> Mainly in post-menopausal women

6
Q

What is an example of a 19-no-steroid?

A

Estradiol

There has been a loss of a methyl at carbon 19, allowing the A ring to be aromatic (planar)

7
Q

What do the dash and wedge represent? In terms of the face of the molecule

A

Wedge = Top phase (B)

Dash = Bottom phase (a)

8
Q

How do we know if steroids are AB/CD Cis/Trans?

A

Cis –> If the molecules at 5 and 10 (or 13 and 14) are on the same face (eg, B)

Trans –> If the molecules are on opposite sides (one A one B)