Meds Flashcards

(30 cards)

1
Q

Metronidazole MoA

A
  • Electron acceptor that reduces cytotoxic compounds that bind to proteins and DNA
  • Disrupts DNA, inhibiting nucleic acid synthesis
  • Bactericidal
  • Need anaerobic environment to reduce in order to be active
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2
Q

Metronidazole Spectrum

A

Oral and GI anaerobes

-Protozoa (Giardia, amoeba, Trichomonas

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3
Q

Metronidazole Clin Use

A

DOC: C diff, anaerobic infections above the neck and below the diaphragm, BV, giardiasis, trichamonaisis, amebiasis, endovascular infection due to Bacteroides species

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4
Q

Metronidazole Interacts

A

Contraindicated: BCG live vaccine, busulfan, disulfiram, lopinavir, ritonavir, tipranavir

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5
Q

Metronidazole ADRs

A

Nausea, vomiting with alcohol consumption!, epigastric distress, abdominal cramps
-Metallic taste

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6
Q

Chloroquine MoA

A

Binds hemazoin in parasitized RBCs causing cell lysis

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7
Q

Chloroquine Spectrum

A

Plasmodium species, extraintestinal amoebas

-Off label: lupus erythematosus, rheumatoid arthritis

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8
Q

Chloroquine Clin Use

A

Malaria tx and prophylaxis

Tx liver abscesses and intestinal wall infections caused by amebas

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9
Q

Chloroquine Interacts

A

Contraindicated: Dronedarone, eliglustat, pimozide, toremifene

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10
Q

Chloroquine ADRs

A

N/V/D, anorexia, abd pain, blurred vision, HA, photosensitivity, tinnitus, muscle weakness

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11
Q

Mebendazole MoA

A

Binds to and interferes with the assembly of the parasites’ microtubules and decreases glucose uptake

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12
Q

Mebendazole Spectrum

A

Drug of choice for whipworm, pinworm, hookworm, and roundworm infections

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13
Q

Mebendazole Clin Use

A

-Must be taken with a high fat meal or else little is absorbed

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14
Q

Mebendazole Interacts

A

Contraindicated: Carbamazepine, cimetidine, phenytoin

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15
Q

Mebendazole ADRs

A

May have abd pain and diarrhea

  • Tolerated very well
  • Contraindicated in pregnancy (category C)
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16
Q

Pyrantel pamoate MoA

A

Depolarizing, neuromuscular-blocking agent

-Paralyzes the worms and they are expelled from intestinal tract

17
Q

Pyrantel pamoate Spectrum

A

Roundworm, pinworm, and hookworm infections

18
Q

Pyrantel pamoate Clin Use

A

Medication is used in animals to de-worm as well as humans

-primarily used to treat pinworm infection in humans

19
Q

Pyrantel pamoate Interacts

20
Q

Pyrantel pamoate ADRs

21
Q

Lindane MoA

A

Directly absorbed into parasites and ova

22
Q

Lindane Spectrum

A

Lice and scabies

23
Q

Lindane Clin Use

A

Tx for head lice, pubic lice, and scabies

-Lotion (scabies) or shampoo (lice)

24
Q

Lindane Interacts

A

Monitor electrolytes w/ magnesium citrate may increase risk of seizures

25
Lindane ADRs
Itching, burning skin, dry skin, rash
26
Permethrin MoA
Causes paralysis and death of the pest
27
Permethrin Spectrum
Lice and scabies
28
Permethrin Clin Use
Tx for head lice, pubic lice, and scabies | -Lotion or cream
29
Permethrin Interacts
None
30
Permethrin ADRs
Skin irritation