Meds

Question 1

Cyclosporine

Answer 1

Calcineurin inhibitor that binds cyclophilin

Blocks T-cell activation by preventing IL-2 transcription

Question 2

Tacrolimus

Answer 2

Calcineurin inhibitor that binds cyclophilin

Blocks T-cell activation by preventing IL-2 transcription

Question 3

Sirolimus (Rapamycin)

Answer 3

mTOR inhibitor, binds FKBP

Blocks T-cell activation and B-cell differentiation by preventing response to IL-2

Question 4

Basiliximab

Answer 4

Monoclonal antibody that blocks IL-2R

Question 5

Azathioprine

Answer 5

Antimetabolite precursor of 6-mercaptopurine

Inhibits lymphocyte proliferation by blocking nucleotide synthesis

Question 6

Mycophenolate mofetil

Answer 6

Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells

Question 7

Glucocorticoids

Answer 7

Inhibit NFkB
Suppress both B and T cell function by decreased transcription of many cytokines
Induce T cell apoptosis

Question 8

Alemtuzumab

Answer 8

anti-CD52 antibody used in CLL

Question 9

Bevacizumab

Answer 9

anti-VEGF antibody used for colorectal cancer, renal cell carcinoma, non-small cel lung cancer

Question 10

Cetuximab

Answer 10

anti-EGFR antibody

Used for stage IV colorectal cancer, head and neck cancer

Question 11

Rituximab

Answer 11

anti-CD20 antibody

Used for B cell non-Hodgkin lymphoma, CLL, RA, ITP, multiple sclerosis

Question 12

Trastuzumab

Answer 12

anti-HER2 antibody

Used for breast cancer, gastric cancer

Question 13

Adalimumab

Answer 13

anti-soluble TNF-alpha

used for IBD, RA, AS, psoriasis

Question 14

Certolizumab

Answer 14

anti-soluble TNF-alpha

used for IBD, RA, AS, psoriasis

Question 15

Golimumab

Answer 15

anti-soluble TNF-alpha

used for IBD, RA, AS, psoriasis

Question 16

Infliximab

Answer 16

anti-soluble TNF-alpha

used for IBD, RA, AS, psoriasis

Question 17

Daclizumab

Answer 17

anti-CD25 (part of IL-2 receptor)

Used for relapsing multiple sclerosis

Question 18

Eculizumab

Answer 18

anti-complement protein C5 antibody

Used for paroxysmal nocturnal hemoglobinuria

Question 19

Natalizumab

Answer 19

anti-alpha 4 integrin antibody

Used for MS, Crohn’s

Question 20

Ustekinumab

Answer 20

anti-IL 12/IL-23 antibody

Used for psoriasis and psoriatic arthritis

Question 21

Abciximab

Answer 21

anti-platelet glycoproteins IIb/IIIa antibody

Used for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

Question 22

Denosumab

Answer 22

anti-RANKL antibody

Used for osteoporosis to inhibit osteoclast maturation

Question 23

Anti-digoxin immune Fab

Answer 23

anti-digoxin antibody

Used as antidote for digoxin toxicity

Question 24

Omalizumab

Answer 24

anti-IgE antibody
used for refractory allergic asthma
used to prevent IgE binding to FceRI

Question 25

Palivizumab

Answer 25

anti-RSV F protein | Used for RSV prophylaxis for high-risk infants