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Flashcards in Meds Deck (46)
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1

Thiazide Diuretics (3)

Chlorothiazide
Chlorthalidone
Hydrochlorothiazde

2

Thiazide MOA

Inhibit sodium and chloride reabsorption in the THICK LOOP OF HENLE and EARLY DISTAL TUBULE
--> this increases urine volume causing a decrease in plasma volume

3

Thiazide- how does it affect the heart?

Decreases cardiac output and lowers stroke volume and lowers BP

4

Adverse effects of Thiazides (5)

Hypokalemia
hypomagnesemia
Hyperglycemia
Hyperuricemia
Hyperlipidemia

5

Ace Inhibitors

captopril
enalapril
Lisinopril
Benazepril
Fosinopril
Ramipril
Quinapril
Moexepril

6

MOA of ACE

block the enzyme that converts ANgiotensin I to angiotensin II.

7

What is angiotensin II?

principal pressor in the RAAS responsible for vasoconstriction, synthesis, and release of aldosterone cardiac stimulation and renal absorption of sodium

8

What happens when Angiotensin II is blocked by ACE?

Vascular resistance is decreased and the secretion of aldosterone is decreased-- decreased water and sodium retention

9

Adverse effects of ACE?

cough
hypotension
Rash
Angioedema
HYPERKALEMIA

10

Contraindication fo ACE?

PTs with renal artery stenosis d/t risk of renal failure

11

ACE inhibitors Clinical use?

First-line drug for HTN
reduce proteinuria
slow progression of neuropathy
good for HTN CHF or HTN and DM
Post MI

12

ARBS

Candesartan
Eprosartan
Irbesartan
Losartan
Olmesartan
Telmisartan
Varsartan

13

MOA of ARBS

INHIBITS/BLOCKS angiotensin II RECEPTOR!

14

MOA difference between ARBS And ACE?

ARB- block receptor
Ace- blocks enzyme

15

Adverse effcts of ARBs

Hyperkalemia
Fatigue
Headache
Dizziness
Insomnia
SINUS CONGESTION

16

ARBs are contraindicated for which patients?

PT with renal artery stenosis

17

Why do some patients need ARB over ACE?

PT cannot tolerate ACE cough s/e

18

Indication of ARBS

HTN and CHF but not approved for post MI

19

Calcium Channel ANTAGONISTS

Amlodipine
Felodipine
Isradipine
Nicardipine
NIfedipine
Verapamil
Bepridil

20

MOA of Calcium Channel ANTAGONISTS

Block L type calcium channels and decrease calcium entry into vascular and cardiac cells this results in reduced CONTRACTILITY in CARDIAC AND VASCULAR MUSCLE

21

Calcium Channel ANTAGONISTS decrease...

Arteriolar dilation and decreased BP

22

Why are CCB contraindicated with HF PT?

bc they also inhibit calcium in cardciac tissue and SLOW conduction of AV node this can decrease contractility and make HF worse

23

clinical use of CCB?

PT with Angina and HTN

24

Why should Nifedipine not be used for HTN Txt?

BC short-acting Nifedipine can cause increased risk of MI bc of reflex tachycardia

25

What are the three classes of Calcium channel ANTAGONISTS?

1. Diphenyalkylamines
2. Benzothiazepines
3. Dihydriopyridine

26

Verapamil belongs to which class of CCB?

Diphenyalkylamines --> vascular and cardiac activity
Txt- HTN Angina and SVT

27

Diltiazem belongs to which class of CCB?

Benzothiazepines-->vascular and cardiac activity
Txt- HTN Angina and SVT

28

Nifedipine belongs to which class of CCB?

Dihydropyridine

29

Nifidipine

greater affinity for calcium channels in the VASCULAR system than in the heart and they provide vasodilation BUT ARE NOT effective in decreasing AV node conduction
TXT ANGINA AND HTN

30

SE of Diphenyalkylamine

Constipation
Bradycardia
Heart block
Worsen CHF