MedStudy Facts Flashcards
(44 cards)
what PFT is obstructive
FEV1/FVC < 70 (actual)
what PFT seperates emphysema and chronic bronchitis
DLCO low - emphysema
DLCO preserved and bronchitis
what PFT is restriction
TLC low (<80% predicted)
what PFT seperates intrinsci and extrinsction
NMD, scoliosis, and obesity
DLCO intrinsic low
isolated DLCO low
pulmonary arterial hypertension
flow volume loop obstructive
shortened loop and left shifted
flow volume loop restrictive
skinny loop shifted to the right
fixed obstruction flow volume loop
flat up and bottom, tracheal stenosis or goiter
Extrathraocic inpiratory
flattening of the bottom part of the curve - vocal cord dysfunction
extrathoracic expiratory loop
flattening of the top - tracheomalacia
positive broncho change
> 12% change
positive challenge test change
> 20 %
IgE monoclonal antibody
omalizumab (need to have high IgE level) - monitor symptoms
IL-5 monocolonal antibody
severe periphral eosinophilia (mepolizumab - Shingrex before), benralizumab, reslizumab (IV infusion)
dupilumab
IL-4/IL-13 (self injection), directly affect the smooth muscle as well as einosphils
blood test for Churg-strauss
p-anca
medical therapy COPD FEV1 50-80
long-actcing bronchov (titropium) (LABA)
medical therapy COPD FEV1 30-50
inhaled glucocorticoids
careful with buproprion
lowers seizure threshold
oxygen therapy
resting PaO2 < 55 or 88% or O2 sat < 89 if evidence of cor pulmonale
apical disease (heterogenous)
lung volume reduction therapy
roflimast
reduced exacerbation (chronic bronchitis)
mortality reduction acute severe COPD
BIPAP
RSBI
predicts weaning failure
< 105 is good
(RR/TV in L)