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Medulloblastoma > Medulloblastoma > Flashcards

Medulloblastoma Flashcards

1
Q

Who grading

A

4

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2
Q

Peak age

A

1st decade

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3
Q

MCC 📍

A

Posterior fossa
Cerebellum vermis near apex of roof 4 th ventricle

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4
Q

Most common site of recurrence medulloblastoma

A

P - fossa

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5
Q

Good prognosis in non-WNT/non-SHH group 4:

A

Gain ➕Chrom 7 ,17
Loss ➖ chrom 8 , 11

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6
Q

MRS medulloblastoma

A

⬆️ cholin
⬇️ NAA

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7
Q

Poor prognosis medulloblastoma

A

Young age < 3 us except ➡️ desmoplastic/ nodular,MBEN
Mets except MBEN
Residual > 1.5 cm
Poor Karnofsky score

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8
Q

Histological type MDB found in all molecular

A

Large cell anaplastic ▶️ poor prognosis 😭
Classic

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9
Q

Large cell anaplastic MDB poor prognosis factor

A

SHH-activated TP53-mut and
non-WNT/non-SHH group 3 with MYC amplification can behave more aggressively.

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10
Q

Desmoplastic/ nodular 📍

A

📍 midline , cerebellar hemispheres

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11
Q

desmoplastic/nodular MDB syndrome

A

Gorlin syndrome

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12
Q

desmoplastic/nodular MDB prognosis

A

Better than other histology type

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13
Q

MDB with extensive nodularity (MBEN) 📍

A

vermis

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14
Q

MDB with extensive nodularity (MBEN) MCC age

A

Infant 👶

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15
Q

MDB with extensive nodularity (MBEN) prognosis

A

Favorable , drop Mets not affect prognosis

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Medulloblastoma (1 decks)

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