Membrane Transport

Question 1

Hematocrit

Answer 1

Fraction of blood volume that is occupied by RBC

Question 2

Transcellular fluid definition and examples

Answer 2

ECF that is trapped within spaces completely surrounded by epithelial cells

Examples: synovial fluid within joints, cerebrospinal fluid (CSF)

Question 3

Interstitial fluid

Answer 3

Found outside the intravascular compartment.

Question 4

Ions of intracellular / extracellular

Answer 4

Intracellular fluid: High in K and low in Na+ and Cl-

Extracellular fluid: High in Na+ and Cl-, low in K+.

Question 5

Cardiac glycosides and what they do

Answer 5

Ouabain: compete with K+ for binding to the extracellular side of E2-P state of pump.

Digoxin: same

Blockage of sodium potassium pump affects secondary transport pumps. Ca2+ affected.

Question 6

Names of Ca pumps

Answer 6

PMCA (plasma membrane Ca2+-ATPase)

SERCAs (sarcoplasmic and endoplasmic reticulum calcium ATPase)

Question 7

Multidrug resistance transporter facts

Answer 7

MDR1 is also called P-glycoprotein.

Pumps a wide range of anticancer drugs out of cancer cells. Makes cells resistant to drugs. No good.

Question 8

Major classes of Secondary Active Transporters

Answer 8

cotransporters (symporters): go same way.

exchangers (antiporters): go opposite way.

Question 9

Ultrafiltration

Answer 9

When hydrostatic pressure exceeds osmotic pressure. water goes out of capillary.