Membranoproliferative Flashcards
(3 cards)
0
Q
Clinical features
A
Proteinuria
Nephrotic syndrome
Haematuria
Nephritic syndrome
Low C3
1
Q
What is MPGN
A
Involves mesangium and capillary walls
Associated with activation of complement system
Type 1 subendothelial electron dense deposits
Type 2 linear deposit in lamina densa of capillary BM (dense deposit disease)
2
Q
Type 1 MPGN
A
Global mesangial cellularity
Exaggerated lobularity of capillary tufts
Thickened capillary walls
Reduplicated BM (tram tracking)
Cresents in 10%
Eosin hyaline deposits in cap lumina -suggests cryoglobulinaemia
Diffuse broad granular C3 in cap loops and mesangium, or mainly mesangial C3
