men as patients - ED

Question 1

treatment options for ED

Answer 1

Treatment includes PDE-5 inhibitors or TRT, if appropriate

Question 2

PDE-5 inhibitors available

Answer 2

o sildenafil (Viagra)
o vardenafil (Levitra)
o tadalafil (Cialis)

Question 3

PDE-5 inhibitor pharmacodynamics

Answer 3

one aspect of a normal erection is the release of nitric oxide in the corpus cavernosum during sexual stimulation
- catabolism of cGMP is responsible for detumescence
- the PDE-5 inhibitors work by blocking the catabolism of cGMP
- blocking cGMP results in an increased number and duration of erections in men with ED

Question 4

sildenafil and vardenafil duration of action

Answer 4

have a 4 hour duration of effectiveness

Question 5

tadalafil duration of action

Answer 5

may assist men to have an erection in response to sexual stimulation for up to 36 hours after a single dose

Question 6

priapism

Answer 6

if pt has erection > 4 hrs, seek emergency medical care