men's reproductive Flashcards
(37 cards)
risk factors of testicular cancer
Family history
Caucasian
Cryptorchidism
HIV infection
Germ Cell Tumors: Seminomas
Arise from immature germ cells
Slow growing, nonaggressive
Easily cured with radiation
Germ Cell Tumors: Nonseminomas
Arise from mature germ cells
More aggressive
Usually treated with surgery
Early CM of testicular cancer
Enlargement of testicle
Painless mass noted
If discomfort present: Ache in groin, Sensation of heaviness
Late CM of testicular cancer
Possible frank pain
Manifestations based on metastatic spread: Cough, Hemoptysis, Swelling of lower extremities, Back pain, Dizziness
BPH: Definition & Risk Factors
Nonmalignant enlargement of prostate: ↑ epithelial cells, ↑ smooth muscle cells, Stromal cells.
RF: Age, Family history, Race/Ethnicity
LUTS: Lower urinary tract symptoms
BPH Etiology
- Hormone Imbalance: Testosterone and estrogen (estradiol)
- DHT Accumulation
What is DHT
Testosterone + 5 alpha-reductase = DHT
Why is DHT important in development of BPH?
Acts on skin: acne
Acts on hair follicles: hair on chest BUT off scalp
Stimulates growth of prostate cells
BPH: Clinical Manifestations
Frequency and urgency
Delay in initiation
Reduction in force
Increased urination time
Dribbling
BPH: Complications
Obstruction
UTI
Renal problems
treatment of BPH
Mild symptoms = watchful waiting
Moderate symptoms = drug therapy: 5-alpha reductase inhibitors, Alpha1-adrenergic antagonists
Severe symptoms = invasive options
Finasteride
class: 5-alpha-reductase inhibitors
Indication: Mechanical obstruction of urethra
MOA: Blocks conversion of testosterone to DHT; Decreases epithelial tissue in prostate
SE: Impotence, Decreased libido (5-10%), Gynecomastia
Side note: Decreases prostate specific antigen (PSA) levels, Used for male-pattern baldness.
Caution in Handling
Will finasteride work in someone with a smaller prostate?
not really, works best on very enlarged prostates
When will the patient see results for finasteride?
6-12 months & have to take this for the rest of their lives.
Dutasteride
class: 5-alpha-reductase inhibitors
Indication: Mechanical obstruction of urethra
MOA:Blocks conversion of testosterone to DHT; Decreases epithelial tissue in prostate
Adverse Effects: Similar to finasteride
Tamsulosin
class: Alpha1-Adrenergic Antagonists
MOA: Relaxes smooth muscle cells, Selective for alpha receptors in the prostate
Indication: Dynamic obstruction of urethra
Adverse effects: Well tolerated
Abnormal ejaculation
When will the patient see the results of tamsulosin?
works quickly and is taken for life.
which race has the highest and lowest rate of prostate cancer?
African-American men = highest
Asians and Native American men = lowest
what age do incidence increase rapidly for prostate cancer?
Incidence increases rapidly after 50.
> 80% of all cases in men > 65 yo.
risk factors for prostate cancer
Age
Familial tendency
High fat diet
CM for prostate cancer
Early: asymptomatic
Later: BPH type presentation, Metastasis: Bone, Lungs
Prognosis: Stage dependent, Early diagnosis
what are the benefits of using PSA?
Small survival benefit with PSA screening in randomized trials.
Use of the PSA test was associated with a 50% drop in prostate cancer deaths in the U.S.
what are the harms of using PSA?
Would take 48 diagnoses of prostate cancer to prevent 1 death.
Only 1 in 3 men with a positive PSA will have prostate cancer.
Many unnecessary biopsies.
Side effects of unnecessary treatment include erectile dysfunction, urinary incontinence, bowel problems.
