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Flashcards in MEN Syndromes Deck (8)
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1
Q

Define what a men syndrome is?

A

Inherited disease resulting in proliferative lesions (hyperplasia, adenomas, and carcinomas) of multiple endocrine organs

2
Q

5 generalities of MEN syndromes?

A
  1. Tumors present at younger age
  2. Multiple endocrine organs are involved
  3. Bilateral
  4. Hyperplasia is seen first usually
  5. Aggressive
3
Q

What are the 3 classic tumors making up MEN type 1 and what is the additional tumor they have recently added? What is the mutations for MEN 1 syndrome?

A

Primary hyperparathyroidism, pancreatic endocrine tumors, and pituitary adenomam (specially lactotroph and somatotroph)

The additional ones are gastrinomas found in the duodenum.

Men 1 tumor suppressor gene

4
Q

What 3 tumors are found in MEN type 2A and what is the mutation?

A

Pheo, medullary thyroid carcinoma and parathyroid hyperplasia.
RET

5
Q

What are the 3 types of tumors in MEN type 2B and what is the mutation?

A

Pheo, medullary thyroid carcinoma, and mucosal neuromas.

Specific point mutation of RET

6
Q

Explain what familial medullary thyroid carcinoma is?

A

Variant of MEN 2a, but only with the medullary thyroid carcinoma.

7
Q

What is the function of the pineal gland?

A

Secrete melatonin.

8
Q

What are the three most common tumors of the pineal gland?

A

Germ cell tumors, pineocytomas and pineoblastomas