Menopause Flashcards

1
Q

Menopause is defined as

A

the cessation of menses due to loss of ovarian activity, average age 51 in the US

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2
Q

Postmenopausal =

A

12+ months after final menses

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3
Q

Perimenopausal/ transition =

A

4-6 years of cycle changes and other sx before total cessation of menses

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4
Q

Premature menopause =

A

ovarian failure before the age of 40

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5
Q

Early menopause age =

A

40-45

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6
Q

Surgical menopause =

A

cessation of menses due to BSO

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7
Q

Menopause is a part of the normal …

A

aging process, is NOT a disease process

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8
Q

Menopause can be early in

A

smokers and in setting of malnutrition

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9
Q

Perimenopause:
Onset age =
Average length =
When does this begin?
What leads to pt’s having sx?

A

47
4-8 years
begins when the menstrual cycles begin to be irregular
erratic fluctuations of hormones lead to sx

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10
Q

Perimenopausal sx =

A

Vasomotor - hot flashes, night sweats, insomnia
Psych - depression, irritability, mood swings
Cognitive - concentration/ memory issues
Sexual - vaginal dryness/ dysparenia
Menstrual changes - longer/shorter cycles, irregular bleeding
other - urinary incontinence, dry itchy skin, wt gain

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11
Q

Physiology of Perimenopausal =

A

decrease synthesis of estrogens and progesterone
GnRH released at max - increasing androgens
testosterone production may continue for several more years after menopause

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12
Q

Types of estrogen:

A

Estrone (E1) = made after menopause
Estradiol (E2) = most common type of estrogen, most potent/ abundant during reproductive years
Estriol (E3) = main type of estrogen in a pregnant person’s bloodstream, prepares for childbirth

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13
Q

Consequences of estrogen loss

A

sx (early) - hot flashes, insomnia, irritability
Physical changes (intermediate) - vaginal atrophy, skin atrophy
Diseases (later) - osteoporosis, Coronary heart disease

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14
Q

Menopausal Menstrual changes

A

Luteal insufficiency - follicles become less responsive to FSH
fewer oocytes available in early follicular phase - FSH levels increase further
Corpus Luteum doesn’t function as well and progesterone secretion is diminished - result heavier menses

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15
Q

Changes in menstrual cycle during menopause

A

shortened cycles - luteal phase stays the same at 14 days but the follicular phase shortens because there are higher rates of follicular maturity

anovulation - accelerated decline in responsive follicles, bleeding episodes eventually spread out and then stop

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16
Q

What causes the follicular phase to shorten during menopause

A

Higher FSH levels cause follicles to mature faster - ovulation occurs earlier (hence the overall cycle is shortened)

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17
Q

Vasomotor symptoms that occur with menopause

A

hot flashes and night sweats
present in 75% of women

18
Q

Hot flashes and night sweats are when

A

there is a sudden sensation of heat centered in face and chest that rapidly becomes generalized
can last 2-4 min - can have one or more per day
average duration is approx 5 years (but can continue for up to 10 after LMP)
can arouse from sleep leading to sleep disturbance

19
Q

What is the most common reason women seek medical attention during menopause?

A

vasomotor sx - can significantly impair quality of life

20
Q

VMS etiology

A

not fully understood
skin temps rise because of peripheral vasodilation followed by drop in core temp

21
Q

How to treat VMS

A

Exogenous estrogen widens thermo-regulatory zone so fewer sx

22
Q

Atrophic Vulvovaginitis is when

A

there is a gradual thinning of the genital mucosa
loss of vaginal rugae (folds)
decreased pliancy of the tissue, less flexible
Drier
pH becomes alkaline, change in microbiome

23
Q

Sexual changes with Atrophic Vulvovaginitis

A

dyspareunia
decreased lubrication with arousal
increased frequency of UTI/ candidal infection
lack of desire, longer arousal cycle

24
Q

Treatment of Atrophic Vulvovaginitis

A

personal lubricants and moisturizers, vaginal estradiol
encourage communication with partners, provide education

25
Q

Recurrent UTI - Genitourinary syndrome of menopause –> is dx when

A

> 2 culture confirmed UTI’s in 6 months or
3 in 12 months

26
Q

Women are at an increased risk when reached menopause

A

cardiovascular health - MI
bone health - osteoporosis
cognitive changes - depression, anxiety, sleep disturbance, brain fog
hair and skin changes - thinning of skin and hair, hirsutism

27
Q

Early and premature menopause is due to

A

ovarian dysfunction
ages 40-45 = early menopause
before age 40 = premature menopause

28
Q

treatment of early and premature menopause

A

unless contraindicated may want to use HRT until natural menopause age (51)

29
Q

Positive menopausal changes include

A

decreased issues with fibroids and endometriosis
end of menstrual migraines and PMS
no more need for contraceptives, no more menses and monthly hormonal cycles

30
Q

Treatment for menopausal sx

A

reassurance - this is a normal aging process
comfort measures - vaginal lubricants, natural products
VMS- estrogen/ progesterone - if contraindicated you can use SSRIs SNRIs clonidine

31
Q

Prolonged, heavy or frequent vaginal bleeding (peri-menopausal care) you should

A

transvaginal US +/- endometrial sampling to exclude hyperplasia/ neoplasia

32
Q

Why do you always have to give estrogen with progesterone

A

to prevent endometrial carcinoma
if the pt has had a hysterectomy - you can give estrogen by itself

33
Q

Special concerns for any vaginal bleeding after one year of amenorrhea

A

must be investigated
high suspicion for malignancy
endometrial polyps
endometrial hyperplasia

34
Q

If estrogen HRT is being used, patients may have

A

spotting

35
Q

Postmenopausal Care and Screening

A

Pap every 3-5 years
Mammogram
Osteoporosis/ Cardiovascular/ Colon cancer risk

36
Q

Pelvic organ prolapse is when

A

descent toward the vaginal introitus of some or all:
- anterior vaginal wall (cystocele)
- posterior vaginal wall (rectocele)
- uterus (enterocele)

37
Q

Pelvic organ prolapse develops _______ and _______ with age

A

gradually
increases

38
Q

Pelvic organ prolapse often seems to the pt to be

A

sudden and concern for a tumor

39
Q

Pelvic organ prolapse risk factors

A

obesity
chronic constipation
operative delivery
multiparity
chronic cough
heavy lifting for work

40
Q

Pelvic organ prolapse clinical presentation

A

smooth/striated appearing, pink bulging tissue at vaginal opening
Cystocele can make voiding difficult
Rectocele can impair bowl evacuation
Prolapse can feel heavy, cause dull backache - but does not cause severe pain

41
Q

Pelvic organ prolapse treatment

A

watchful waiting with reassurance if not bothersome
pelvic floor exercises
pessary
surgical repair (if uterus then hysterectomy)
Vaginal obliterative procedure in select pts