Menopause Flashcards

(47 cards)

1
Q

Def: Pre-menopause

A

Regular periods

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2
Q

Def: Peri-menopause

A

Irregular periods (Less or more frequent)
≥7 day differences in length between consecutive cycles

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3
Q

Def: Post-menopause

A

No periods > 12 months

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4
Q

Def: Premature ovarian insufficiency

A

Menopause occurring < 40 years old

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5
Q

Def: Early menopause

A

Menopause occurring ages 40-44

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6
Q

What is the average age of menopause in the UK

A

51

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7
Q

What is the average duration of menopause symptoms?

A

7.4 years

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8
Q

What is the average number of symptoms of menopause?

A

7

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9
Q

When are menopause symptoms usually most severe?

A

Late peri- to early post-menopause

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10
Q

What are some of the impacts of menopause symptoms?

A

Effect on home, work, social and sex liufe

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11
Q

What are some symptoms that won’t improve in the menopause?

A

Dry vagina
Painful sex
Urinary symptoms

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12
Q

What are the levels of FSH and oestrogen during menopause?

A

Variably high FSH
Low oestrogen levels (Causing high FSH)

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13
Q

What are the most common 3 menopause symptoms?

A
  • Night sweats
  • Hot flushes
  • Mood swings
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14
Q

What are some other symptoms of menopause?

A
  • Memory loss
  • Aches and pains
  • Period problems
  • Anxiety
  • Brain fog
  • Dry skin and hair (Itchiness)
  • Weight gain
  • Dizziness
  • Tiredness
  • Palpitations
  • Depression
  • Painful sex (Dyspareunia)
  • Recurrent UTI symptoms
  • Headaches
  • Pins and needles
  • Lack of energy
  • Irritability
  • Loss of sex drive
  • Insomnia
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15
Q

What are some other names for vulvo-vaginal atrophy?

A

Genitourinary syndrome of the menopause (GMS)
Urogenital atrophy

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16
Q

What is the main age cut-off for FSH testing in the menopause?

A

45 as FSH will fluctuate with the menopause
(Unless women aged >50 who want to stop contraception before 55)

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17
Q

Investigations in women >45 with atypical menopause symptoms

A

2 x FSH levels 6 weeks apart

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18
Q

Investigation of women 40-45 with menopausal symptoms and/or iatrogenic amenorrhoea (E.g. hysterectomy)

A

2 x FSH levels 6 weeks apart

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19
Q

Investigation of women < 40 with menopausal symptoms

A

FSH
E2
TFT
Glucose
Prolactin
Free androgen index (FAI)

20
Q

Investigations of women <35 with menopausal symptoms

A

Chromosomal and autoimmune screening

21
Q

How do FSH results affect HRT usage?

A

HRT can be started independant of FSH results

22
Q

Contraception basics in peri-menopausal women aged < 40

A
  • Premature insufficiency of ovaries may be transitional →
  • Continue with contraception
23
Q

Contraception basics in peri-menopausal women aged 40-49

A
  • Contraception can be stopped:
    • 2 years after last “natural” menstrual period (Not while on hormonal contraception, etc)
    • 2 years after 2 results of FSH ≥ 30 IU/L, taken at least 4 weeks apart
24
Q

Contraception basics in peri-menopausal women aged ≥50

A
  • Contraception can be stopped:
    • 1 years after last “natural” menstrual period (Not while on hormonal contraception, etc)
    • 1 years after 1 results of FSH ≥ 30 IU/L
25
Contraception basics in peri-menopausal women aged ≥55
- Contraception can be stopped even if still having periods due to poor oocyte quality - Might consider continuing contraception for another year or two if periods are troublesome (I.E. non-contraceptive indications)
26
Lifestyle management options for menopause
- Healthy diet (Exclude phytoestrogens) - Regular exercise (Weight bearing, outdoors) - Healthy weioght - Good sleep hygeine - No smoking - Limited alcohol and caffeine - Reducing stress (Yoga, mindfullness, relaxation techniques) - CBT
27
Environmental management options for menopause
- Cooler ambient temperature - Good ventilation - Suitable clothing (Intelligent fabrics, cotton) - Neck, and-held or desk fans - Neck cooling scarf - Cooling spray
28
Non-hormonal management options for menopause (Not much evidence)
- Herbal medications - St John’s Wort, Black Kohosh, Sage - Non-hormonal medical treatment - SSRIs, Gabapentin, Oxybutinin, Clonidine - Complementary medicine - Acupuncture, homeopathy, aromatherapy, hypnotherapy, acupressure
29
Benefits of HRT in menopause
- Reduction in vasomotor symptoms (Hot flushes, night sweats) - Improvement of low mood association with the peri-menopause - Improvement of sexual and cognitive function - Reduction of osteoporosis risk and fragility fractures - Prevention and treatment of urogenital and vulvovaginal atrophy (Can usually be controlled by vaginal oestrogen alone) - Decreased risk of cardiovascular disease < 60
30
Risks of HRT in menopause
- Increased breast cancer risk - Same risk as CHC, alcohol drinking, smoking - Much lower risk than high BMI - Oestrogen only HRT can decrease breast cancer risk - Increased VTE risk (Oral HRT) - Increased CVD risk > 60
31
Contraindications for HRT in menopause
- History of breast cancer or endometrial cancer - Coronary heart disease, TIA or stroke - Active liver disease - Unexplained vaginal bleeding
32
HRT in women with premature ovarian insufficiency:
- Give HRT until the average age of menopause (51) - CHC (Continuously) could be considered as alternative unless contraindicated - HRT does not add risks compared to women without POI - Continue with contraception
33
HRT in women with early menopause:
Consider strongly giving HRT until the average age of the menopause (51)
34
What are the 2 main categories of HRT?
Oestrogen only (Estradiol) Oestrogen + Progesterone
35
How can HRT be taken?
Trans-dermally Orally
36
What are the 3 main forms of transdermal HRT?
Gel Spray Patch
37
What is the main indicator of whether to give oestrogen only or oestrogen + progesterone HRT
Hysterectomy or Mirena coil If yes, then oestrogen only is given
38
Why is oestrogen only HRT only given in cases of hysterectomy or Mirena coil?
Unopposed oestrogen increases risk of endometrial hyperplasia and therefore endometrial carcinoma Hysterectomy removes the endometrium and Mirena coil opposes oestrogen
39
Describe the treatment regime for HRT treatment for peri-menopause
oestrogen + progesterone is given sequentially (2 weeks a month)
40
Describe the treatment regime for HRT treatment for post-menopause
oestrogen + progesterone is given continuously (Period free)
41
1st line management of vasomotor and mood symptoms of menopause
HRT
42
Is there an age limit on HRT?
No
43
How can HRT be stopped?
Can be both gradually stopped or immediately stopped depending on patient choice
44
What are the benefits of trans-dermal HRT?
No VTE risk Better for symptom control Lower CVD risk
45
Indications for transdermal HRT
- Individual preference - Poor symptom control with oral HRT - GI disorder affecting oral absorption - Increased VTE risk (E.g. Obesity, FHx) - Variable blood pressure control
46
Side effects of oestrogenic HRT
- Bloating - Breast enlargement - Breast tenderness - Fluid retention - Headaches/Migraines - Leg cramps - Mood swings - Nausea§
47
Side effects of progestrogenic HRT
- Acne - Anxiety - Bloating - Breast enlargement - Breast tenderness - Depression - Headaches/Migraines - Hirsutism - Lower abdo/pelvic/back pain - Mood swings