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Mesa Flashcards

(59 cards)

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1
Q

3 outcomes of acute inflammation

A

resolution
scar
chronic inflammation

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2
Q

first step in inflammation

A

vasodilation

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3
Q

vasodilation –>

A

increased vascular permeability

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4
Q

increased vascular permeability –>

A

leakage of exudate

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5
Q

leakage of exudate –>

A

margination, rolling, adhesion

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6
Q

margination, rolling, adhesion –>

A

transmigration/diapedesis

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7
Q

transmigration/diapedesis –>

A

chemotaxis

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8
Q

chemotaxis –>

A

PMN activation

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9
Q

PMN activation –>

A

phagocytosis

- recognition, attachment, engulfment, killing (degradation and digestion)

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10
Q

phagocytosis –>

A

termination

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11
Q

main cell in acute inflammation

A

neutrophil/polymorphonuclear leukocyte/PMN

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12
Q

5 cardinal signs of inflammation

A 
rubor
calor
tumor
dolor
functio laesa
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13
Q

leukocyte activation means

A

produce eicosanoids (part of cell membranes: prosaglanding/thromboxanes, leukotrienes, lipoxins)
undergo degranulation
secrete cytokines

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14
Q

histamine from

A

mast cells and basophils

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15
Q

histamine function

A

powerful vasodilator

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16
Q

serotonin from

A

platelets and enterochromaffin cells

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17
Q

serotinin function

A

vasodilation

evokes NO synthase from arginine

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18
Q

bradykinin

A

from circulating plasma

increase permeability, non vascular smooth muscle contration (bronchail), PAIN

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19
Q

prostaglandins produce

A

pain
fever
clotting

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20
Q

leukotrienes function

A

chemotaxis
vasoconstriction
increased permeability

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21
Q

lipoxins function

A

inhibit chemotaxis
vasodilation
counteract leukotrienes

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22
Q

PAF

A

platelet activating factor
from many cells
active platelets
vasoconstrict/bronchoconstrict

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23
Q

chemokines are

A

small proteins which are attractants for PMNs

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24
Q

cytokines are

Study These Flashcards
A

proteins produced primarily by lymphocytes and macrophages, mediate inflammatory and immune reactions

25
nitric oxide is a
vasodilator
26
cells of chronic inflammation
lymphocytes and macrophages
27
causes of caseating granulomas
mycobacteria, syphilis, some fungi
28
causes of non-caseating granulomas
sarcoidosis, leprosy, Crohn's
29
differentiation is key concept in
neoplasia gain of specialization, loss of versatility unidrectional
30
EGF made in
platelets and macrophages
31
EGF present in
saliva, milk, urine, plasma
32
EGF acts on
keratinocytes to migrate/divide | fibroblasts to produce granulation tissue
33
TGF - alpha made in
macrophages, T-cells, keratinocytes
34
TGF - alpha effects
similar to EGF | also effect hepatocytes
35
HGF made in
mesenchymal cells
36
VEGF made in
mesenchymal cells
37
VEGF triggered by
hypoxia
38
VEGF functions
increases vascular permeability mitogenic for endothelial cells key in promoting granulation tissue
39
PDGF made in
platelets and may other cell types
40
PDGF function
chemotactic for many cells mitogen for fibroblasts angiogenesis key player in granulation tissue
41
FGF made in
many cell
42
FGF functions
chemotactic and mitogenic for fiibroblasts and keratinocytes re-epithelialization angiogensis,wound contraction hematopoiesis
43
TGF-beta made in
many cells including macrophages
44
TGF-beta functions
stimulates migration/proliferation of fibroblasts increases collagen synthesis contraction of scar limit and terminate inflammatory responses
45
KGF made in
fibroblasts
46
KGF function
stimulates keratinocyte migration, proliferation, differentiation
47
IGF made in
macrophages, fibroblasts
48
IGF stimulates
sulfated proteoglycans collagen keratinocyte migration fibroblast proliferation action similar to GH
49
TNF made in
macrophages, mast cells, T cells
50
TNF functions
activates macrophages (cachexin) key influence on other cytokines major TNF in TNFa
51
interleukins made in
macrophages, mast cells, T cells and many other cells
52
interleukin function
chemotaxis angiogenesis regulation of other cytokines
53
interferons made in
macrophages, fibroblasts
54
interferon functions
active macrophages inhibit fibroblasts regulate other cytokines trigger defense mechanisms
55
collagen one
bONE
56
collagen two
carTWOlage
57
collagen three
reTHREEculate (reticular fibers)
58
collagen four
FLOOR | forms basement membrane (important in kidney)
59
angiogenesis stimulated/regulated by
VEGF

IDIT (3 decks)

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