Metabolic Bone Disease: Radiology Flashcards

1
Q

What imaging looks at bone density? (3)

A

Xrays, CT and bone densitometry all look at density

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2
Q

What imaging looks at bone biochemical composition?

A

MRI

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3
Q

What imaging looks at bone turnover?

A

turnover (osteoblastic activity of bones) Radionuclide bone scans

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4
Q

What is a RADIOLOGICAL SIGN

A

A change in imaging appearance, whether structural or functional, that may point towards a pathology

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5
Q

How do you diagnose osteoporosis? Score for positive diagnosis?

A
bone densitometry (e.g. dual energy absorptiometry (DEXA))
T- score 2.5SD below mean of a healthy young person
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6
Q

Radiological signs that may indicate osteoporosis? (3)

A
  • Loss of cortical bone/thinning of cortex
  • Loss of trabeculae
  • Insufficiency fractures
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7
Q

What is an insufficiency fracture?

A

Stress fractures due to normal stress on abnormal bones

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8
Q

Common sites of insufficiency fractures?

A
  • Sacrum
  • Underside of femoral neck
  • Vertebral bodies
  • Pubic rami
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9
Q

Types of imaging for insufficiency fractures and their results?

A
XR/CT:
-	Initially normal
-	Can get periosteal reaction and callus
-	More commonly increased sclerosis around fracture lines
MRI:
-	Bone oedema
BONE SCAN:
-	Increased osteoblastic activity as bones attempt to heal
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10
Q

Bones With decreased bone mineral is named what?

A
  • Osteopaenic bone

- Soft bone

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11
Q

Bones With Too much un-mineralised osteoid:

A
  • Looser’s zone
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12
Q

OSTEOMALACIA can result in what (if Ca remains low)

A

May result in 2ndary HPT if calcium remains low

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13
Q

Radiological signs of osteomalacia? (5)

A
  • Mature skeleton
  • Osteopaenia
  • Looser’s zones
  • Codfish vertebrae
  • Bending deformities
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14
Q

When does rickets occur?

A

Osteomalacia before growth plate closure

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15
Q

LOOSER’S ZONES common sites? Why do these occur here? (5)

A

Pseudofractures at high tensile stress areas

  • Medial proximal femur
  • Lateral scapula
  • Pubic rami
  • Posterior proximal ulna
  • Ribs
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16
Q

Describe a Looser zone on a radiological scan

A

Typically, short lucent lines with irregular sclerotic margins

17
Q

Describe CODFISH VERTEBRAE? what are they seen in?

A

 Biconcave deformity of vertebrae
 Seen in:
- Osteomalacia
- Osteoporosis

18
Q

radiological scan of rickets?

A
  • Indistinct/frayed metaphyseal margin
  • Widened growth plate with calcification
  • Cupping/splaying metaphyses due to weight bearing
  • Enlargement of anterior ribs
  • Osteopaenia
19
Q

Main areas of bone resorption? (4)

A
  • Subperiosteal
  • Subchondral
  • Intracortical
  • Brown tumours
20
Q

What does type of radiology in osteomalacia depend on?

A

Age and closure of growth plates

21
Q

Bone density and PTH levels/resorption in 2ndary HPT?

A

shows bone resorption and increased density

22
Q

renal osteodystrophy has Features of what other diseases?

A
  • Osteomalacia
  • Osteoporosis
  • 2o Hyperparathyroidism
23
Q

What is seen in renal osteodystrophy in radiological scans? (4)

A
  • Subperiosteal
  • Subchondral
  • Intracortical
  • Brown tumours
    ^ lesions

 Sclerosis- vertebral endplates giving a rugger jersey spine- increased density at endplates and reduced density in middle of vertebrae
 Soft tissue calcification (vessels, cartilages)

24
Q

What is seen in radiology of Pagets? (5)

A
  • Cortical thickening
  • Bone expansion
  • Coarsening of trabeculae
  • Osteolytic, osteosclerotic and mixed lesions
  • Osteoporosis circumscripta (holes in the bones
25
Q

What is raised in the serum of someone with pagets disease?

A

Serum alk phosophatase

26
Q

What is seen in the urine of someone with pagets disease?

A

Hydroxyproline

27
Q

What is mono/polyostotic Pagets?

A

it only affects 1 piece of bone). It usually starts from one end of the bone and then spreads to the other side. It does not usually cross the joint.
Poly means more than 1 piece of bone will be affected