Metabolism Flashcards

(50 cards)

1
Q

Metabolism

A

The sum of all chemical reaction that occur in the body

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2
Q

Catabolic reactions

A

Break down large chemicals and release energy

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3
Q

Anabolic reactions

A

Build up large chemicals and required energy

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4
Q

Ingestion

A

The acquisition and consumption of food and other raw materials

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5
Q

Digestion

A

The process of converting food into a usable soluble form to pass through membranes in the digestive tract and enter the body

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6
Q

Absorption

A

The passage of nutrient molecules through the lining of the digestive tract into the body proper by diffusion or active transport

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7
Q

Transport

A

The circulation of esstianal compounds required to nourish the tissues and the removal of waste products from the tissues

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8
Q

Assimilation

A

The building up of new tissues from digested food materials

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9
Q

Excretion

A

The removal of waste products produced during metabolic processes

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10
Q

Synthesis

A

The creation of complex molecules from simple ones

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11
Q

Regulation

A

The control of physiological activities to maintain the body’s internal environment

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12
Q

Homeostasis

A

The steady state of the internal environment

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13
Q

Irritability

A

The ability to respond to a stimulus

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14
Q

Growth

A

An increase in size caused by cell division and synthesis of new materials

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15
Q

Reproduction

A

The generation of additional individuals of a species

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16
Q

Respiration

A

The conversion of the chemical energy in molecular bonds into the usable energy needed to drive the process of living cells

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17
Q

Aerobic respiration

A

Respiration in the presence of oxygen

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18
Q

Dehydrogenation

A

Removal of high-energy hydrogen atoms from organic molecules

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19
Q

Glycolysis

A

Series of reactions that leads to the oxidative breakdown of glucose into 2 molecules of pyruvate, ATP, and reduction of NAD+ into NADH
In the cytoplasm

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20
Q

Glycolytic pathway

A
  1. Glucose to glucose 6-phosphate by hexokinase
  2. To fructose 6-phosphate by phosphoglucose isomerase
  3. To fructose 1,6-biphosphate by phosphofructokinase
  4. To glyceraldehyde 3-phosphate + dihydroxyacetone phosphate by aldolase
    Dihydroxyacetone by triose phosphate isomerase
  5. To 1,3-diphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase
  6. To 3-phosphoglycerate by phosphoglycerate kinase
  7. To 2-phosphoglycerate by phosphoglycerate mutase
  8. To phosphoenolpyruvate by enolase
  9. To pyruvate by pyruvate kinase
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21
Q

Substrate level phosphorylation

A

Formation of ATP by direct conversion of a higher energy substrate into lower energy product

22
Q

Fermentation

A

Reactions involved in reducing pyruvate into ethanol or lactic acid in the absence of oxygen

23
Q

Alcohol fermentation

A

Pyruvic acid to acetaldehyde by pyruvate decarboxylase to ethanol by alcohol dehydrogenase

24
Q

Lactic acid fermentation

A

Pyruvic acid to lactic acid by lactate dehydrogenase

25
Cellular respiration
Aerobic process Occurs in the mitochondria Yield 36-38 ATP 3 stages: pyruvate decarboxylation, citric acid cycle, electron transport chain
26
Pyruvate decaroxylation
Pyruvate transported into the mitochondrial matrix Decarboxylated Acetyl group transferred to coenzyme A to form acetyl-CoA NAD+ reduced to NADH
27
Citric acid cycle/Krebs cycle
2-carbon acetyl group from acetyl-CoA combines with oxaloacetate to form 6-carbon citrate 2 CO2, 3 NADH, 1 FAHD2 and 1 GTP generated per cycle
28
Electron transport chain
Inside of inner mitochondria membrane High-energy potential electrons transferred from NADH and FADH2 to oxygen by a series of carrier molecules that pump H+ into the intermembrane space creating a concentration gradient
29
Cytochromes
Electron carriers that contain a central iron atom capable of undergoing a reversible redox reaction
30
Oxidative phosphorylation
Respiratory enzymes continually create a concentration gradient. H+ passes through ATPase, releasing energy to convert ADP to ATP Produce 36-38 ATP
31
Fats energy
Triglycerides stored in adipose tissue Hydrolyzed by lipases to fatty acid and glycerol Glycerol converted in PGAL Activated in cytoplasm with 2 ATP, transported into the mitochondrion and go through series of beta-oxidation cycles converting into 2-carbon fragments which are converted in acetyl-CoA
32
Transamination
Proteins lose amino group to form an a-keto acid | Converted to acetyl-CoA, pyruvate, or intermediates
33
Oxidative deamination
Removes ammonia molecules directly from an amino acid
34
Photosynthesis
Coverts CO2 and water into glucose and oxygen | In chloroplast
35
Light reactions
Photolysis reactions Absorption of a photon by a chlorophyll molecule P700 molecule in photosystem I excites electrons to a higher energy level Flow along the cyclic or noncyclic electron flow
36
Cyclic electron flow
Excited electron of P700 move along electron carriers Series of redox reactions returns electrons to P700 Cyclic photophosphorylation produces ATP
37
Noncyclic electron flow
Photons excite electrons in P700 in photosystem I Reduce NADP+ to NADHP Photons excite electrons in P680 in photosystem II, travel down electron carrier chain and oxidize P700 Produces ATP by noncyclic photophosphorylation Water split into 2 H+ and O- to reduce P680 Oxygen atoms combine to form O2
38
Dark reactions
Carbon-fixation or reduction synthesis reactions | Uses ATP and NADPH produced by light reactions to reduce CO2 to carbohydrates
39
Calvin cycle
CO2 fixed to ribulose bisphosphate Splits into 2 molecules of phosphoglyceric acid Phosphorylated by ATP and reduced by NADPH to give glyceraldehyde-3-phosphate (PGAL) 2 PGALS convert to glucose Cycle takes place 3 times
40
Enzymes
Decrease reaction activation energy Do not alter equilibrium constant Are pH and temperature sensitive Very selective
41
Substrate
The molecule which an enzyme acts upon
42
Active site
The area on the enzyme which the substrate binds
43
Lock and Key theory
The spatial recognition structure of an enzyme's active site is exactly complementary to the specific substrate
44
Induced Fit theory
The active site has flexibility of shape When the appropriate substrate comes in contact with the active site, the conformation of the site changes to fit the substrate
45
Enzyme specificity
Temperature - as temp increases, rate increases until an optimum temp is reached beyond which heat alters the shape of the active site and deactivates it pH Concentration - increasing substrate concentration increases rate until all active sites are occupied (max velocity Vmax)
46
Competitive inhibition
Molecules similar to the substrate that bind to the active site of the enzyme, competing with the substrate and interfere with enzyme activity
47
Noncompetitive inhibition
A substance that forms strong covalent bonds with an enzyme at, near or fear from the active site, making it unable to bind with its substrate Irreversible
48
Allosteric site
An area on the enzyme that is not the active site
49
Cofactor
Nonprotein molecules (metal cations or coenzymes) that incorporate with enzymes to become active
50
Prosthetic groups
Cofactors that bind to the enzyme by strong covalent bonds