Flashcards in Metabolism Integrated Deck (14):
What can acetyl coA be converted into?
How is gluconeogenesis different to glycolysis?
By passes some steps
Does not produce pyruvate or acetyl coA
Describe the process of gluconeogenesis?
Pyruvate —> oxaloacetate
Oxaloactate —> phosphoenolpyruvate (PEP carboxykinase)
—> F16BP loosing 6 ATP
F16BP—> F6P (F16BPase)
G6P—> glucose (G6Pase)
Where an proteins enter carbohydrate metabolism?
Pyruvate (then stimulate gluconeogenesis)
How can lipids I enter carbohydrate metabolism?
Fatty acids —>acetyl coA
This means no pyruvate is produced so gluconeogenesis cannot be stimulated
What happens when you exercise?
Increase glucose transporters in muscle
ADRENALINE = increase muscle glycolysis
Increase fatty acid release
What happens when we start to respire anaerobically?
Lactate is converted back to glucose by liver
Where are hexokinase 1 and 4 found?
What are differences between HK 1 and 4?
High glucose affinity
Reaches maximum activity at low glucose conc
Highly sensitive to g6P inhibition (so if too much g6p then it will stop)
What do beta cells release as well as insulin?
What is GLP1 and what does it do?
Glucagon like peptide 1
Drug to treat type 2 diabetes
Makes the beta cells produce more insulin
What happens when we eat?
More insulin, less glucagon
Liver = takes up glucose and stores it as glycogen
Muscle = takes u glucose
Adipose tissue = makes more fat
What happens when glucose levels begin to fall?
More glucagon, less insulin
Liver = glycogenolysis, gluconeogenesis