Metabolism - Lecture Twenty-Nine Flashcards
Fatty Acid Oxidation
Excess energy consumed as glucose
Stored as fat
Fatty acids are preferred
As fuel for most tissues under normal conditions
Why store fuel as fats?
Fatty acids are more reduced than carbohydrates
Where is TAG stored?
In adipose tissue
How do we get TAG back in the form of energy?
Signals activate a class of enzymes called lipase. The lipase cleave the FFA (free fatty acids)
Why are fatty acids activated?
For oxidation
When are fatty acids activated?
Before the fatty acid enters the mitochondria
How are fatty acids activated?
By attachment to CoA making fatty acyl-CoA
The fatty acyl-CoA must pass through two membranes
Outer membrane through the fatty acyl-CoA carrier
Inner membrane which requires the conversion to fatty acyl-carnitine
Beta-Oxidation
Uses fatty acids with an even number of carbons that are saturated and cuts carbon chains into 2 carbon pieces
Beta-Oxidation and ATP
No ATP is made in beta-oxidation
Energy released in beta-oxidation is transferred to?
The coenzymes NAD and FAD
The product of beta-oxidation
Acetyl-CoA
Reaction one of beta-oxidation
Oxidation of FAD to FADH2
Reaction two of beta-oxidation
Hydration (addition of H2O)
