Meth - Ley

Question 1

Meth causes the release of DA, S, and NE where?

Answer 1

CNS and PNS

Question 2

t/f: meth crosses the bbb

Answer 2

true

Question 3

meth use is comorbid for which psych conditions?

Answer 3

anxiety
depression
ADHD
mania
conduct d/o
obesity
ASPD

Question 4

when do most meth users see dependence?

Answer 4

young; around 13-17; used multiple substances and used daily

Question 5

What is the attraction of meth?

Answer 5

desire to cope with emotional stress
stay awake
enhance sex
reduce weight

Question 6

how can you take meth?

Answer 6

smoke it
snort it
eat it
drink it
shoot it

Question 7

about what percent of teens say it would be easy for them to get ahold of meth?

Answer 7

1 in 4

Question 8

why are most children in HI in foster care?

Answer 8

meth moms

Question 9

compared to cocaine users, how do meth users look?

Answer 9

1. more likely to be single, white, unemployed
2. use daily and at younger age
3. experience depression and thoughts of self harm
4. more family issues, more weed
5. more HIV pos

Question 10

meth stimulates release and (pre/post) synaptic uptake of S, D, and NE

Answer 10

presynaptic

Question 11

it takes (single/multiple) doses of meth to impair cognitive fxn

Answer 11

one fucking dose

Question 12

how is meth metabolized?

Answer 12

hepatic hydroxylation and dealkylation

Question 13

inhibitors of which CYP decreases meth elimination?

Answer 13

2D6

Question 14

when does meth plasma concn peak?

Answer 14

2.6-3.6 hours

Question 15

what is the half life of meth?

Answer 15

10 hours

Question 16

how many percent above baseline does meth increase dopamine?

Answer 16

1200%

Question 17

how long does the cocaine high last?

Answer 17

15-30 minutes

Question 18

how long does the meth high last?

Answer 18

8-24 hours

Question 19

t/f: street meth is highly PURE

Answer 19

true; 90-100% pure in crystal

Question 20

tolerance to meth is….

Answer 20

IMMEDIATE

Question 21

what are the acute effects of meth?

Answer 21

Heightened awareness, grandiosity, feeling of being alive, sexual arousal, increased self confidence.
Single doses improve cognition.
Nervousness, insomnia, jerky movements, anxiety, sweating, palpitations, incessant talking, confusion, irritability, bruxism, hyperthermia, dizziness, pupillary dilation, impaired speech, tremors, vision loss.

Question 22

what are the common causes of death from meth?

Answer 22

homicide
suicide
MVAs
sales/distribution

Question 23

What are the biological causes of death from meth?

Answer 23

stroke
CV collapse
pulmonary edema
MI 
renal failure

Question 24

what are the long term psychological effects of meth?

Answer 24

chronic anxiety
depression
anger
panic
paranoia
tinnitus

Question 25

what are the greatest areas of volume loss from chronic meth use?

Answer 25

``` limbic system (emotion and reward) hippocampus (memory) ```

Question 26

what are the cognitive changes in the first few weeks of meth use?

Answer 26

deficits in decision making, accuracy, and speed

Question 27

Frontal lobe damage in meth is related to...

Answer 27

the amount of use; may contribute to craving

Question 28

What explains affective dysregulation in meth use?

Answer 28

metabolic abnl's in the limbic system

Question 29

meth use results in reduced (DA/S) transporter density

Answer 29

S

Question 30

t/f: meth is neurotoxic

Answer 30

true

Question 31

What are the effects on the newborn born to a crack mom | /

Answer 31

``` low birth weight smaller subcortical brain volume poor visual recognition increased aggression impaired social adjustment difficulties with math and language ```

Question 32

what causes meth mouth?

Answer 32

``` vasoconstriction decreased salivary flow vomiting bruxism high sugar abandon oral hygeine ```

Question 33

what are the withdrawal sx from meth?

Answer 33

Symptom clusters Hyperarousal (agitation, craving, dreams) Vegetative symptoms (sadness, anhedonia, increased appetite) Anxiety Dysphoria, affective instability, sleep disturbance Apathy syndrome

Question 34

most of our meth treatment comes from the model from what other drug?

Answer 34

coke

Question 35

What are the major tx models for meth?

Answer 35

CBT contingency model matrix model

Question 36

What are the challenges in treating meth addiction?

Answer 36

poor treatment engagement and drop out, high relapse rate, dysphoria and cognitive impairment

Question 37

the matrix models uses what three approaches?

Answer 37

cognitive behavioral psychological

Question 38

What are the goals of the matrix model?

Answer 38

educate about addiction involve family 12 step testing

Question 39

what can you give a recovering meth addict to deal with dysphoria, craving, and cognitive impairment/

Answer 39

SSRI

Question 40

what does buproprion do for a meth head?

Answer 40

reduces the desire to use

Question 41

what types of agonist replacements can you give a meth head?

Answer 41

modafinil, ritalin

Question 42

What do you give a meth user for pain?

Answer 42

baclofen

Question 43

What do you give a meth head to lower hyperarousal, anxiety, and withdrawal symptoms?

Answer 43

mirtazapine