Method of Modification- Antipsychotics Description Flashcards
Introduction:
Antipsychotic meds can be administered to a patient during or after psychotic episode, either in a psychiatric ward or via self-administration
2 types: convential and atypical
Both work by altering activity lvls of neurotransmitters.
Conventional:
E.g- Chlorpromazine
Blocks action of NT dop- it is an antagonist of D2 receptors; also blocks dop rec subtypes D1, D3, D4 and D5
Pre-syn neuron releases dop in to synapse
Receptor sites on post-syn are blocked by chlorpro, reducing dop activity in this area.
This causes pre-syn to release more dop. H/O, in time, production will slow bc it is depleted, t/f less dop in synapse.
Due to lower lvls of dop released by pre-syn and the action of chlorpro- reduction in neural activity.
Reduction in dop in mesolimbic path is thought to be linked to decline in pos symptoms of schz.
Atypical:
Newer/ 2nd gen
Developed since 1990’s
Some report atypical antipsychs are diff to conven as they are received at fewer D2 sites and at more D1 and D4 sites.
Also, most atypical antipsychs antagonise serotonin sites 5-HT2A to the same degree as tey antagonise D2 receptor sites.
Another diff: the time in which they occupy receptor sites. Seeman + Lee report on the ‘fast-off theory’ : suggests that atypical bind more loosely to D2 rec sites, meaning that although they still block the site, it does not last long enough to produce side effects.
