Metoclopramide (Reglan) Gastro

Question 1

Medication Class for Metoclopramide

Answer 1

Dopamine receptor antagonist

Prokinetic which encourages movement
Antiemetic which works against vomitting.

Question 2

MOA of Metoclopramide

Answer 2

Increases GI motility and promotes stomach emptying
Stimulates the smooth muscle with anticholinergic effects
Impacts dopamine receptors helping to reduce nausea/ vomitting

Question 3

Therapeutic Use of Metoclopramide

Answer 3

Chemotherapy
Anesthesia
Pain Medication
Gastroparesis
GERD

Question 4

Must Know Side Effects for Metoclopramide

Answer 4

Fatigue
Sedation
Headache
Dry mouth
Constipation

Question 5

What are some side effects from long term use of metoclopramide?

Answer 5

Tardive Dyskinesia (TD)
Erratic movements of tongue
Excessive Blinking
Lip- smacking
Jerking of extremities
Puffing of cheeks
Involuntary spasms
Tremors
Muscle Rigidity

Neuroleptic Malignant Syndrome (NMS)

Muscle rigidity
Tachycardia
High Fever
Sweating

Question 6

PT Education for Metoclopramide

Answer 6

Drink fluids
Avoid heavy machinery
Rinse mouth frequently and suck on sugar free candy
DO NOT TAKE if affected with Parkinson’s Disease
May worsen symptoms