MHC Antigen Presentation. Flashcards
What kind of antigens are presented to what MHC-2 molecules?
Exogenous antigens.
What cells present exogenous antigens to to MHC-2 molecules?
CD-4+ helper T cells.
How are exogenous antigens captured?
They are captured and endocytosed via phagocytes or endosomes.
What happens once an immune cell captures a pathogen?
It breaks it down and processes the antigens into peptides of around 12-24 amino acids so they can be read by the MHC-2.
What 3 cells are capable of processing and presenting antigens to MHC-2 molecules?
Dendritic cells.
Macrophages.
B cells.
What MHC molecules deal with endogenous antigens?
MHC-1 molecules.
What immune cells recognise endogenous antigens?
CD-8+ cytotoxic T cells and killer T cells.
What cells will present an antigen on its MHC-1 molecule?
An infected cell.
How are endogenous antigens processed/
They are taken from the cytoplasm and are cut up by the proteosome.
The peptides are around 8-10 amino acids in length.
What cells can present antigens via an MHC-1?
All nucleated cells.
What is the major difference in the ability of a T cell and a B cell to recognise an antigen?
B cell receptors can recognise soluble antigens by themselves.
T cell receptors only recognise antigens when they are presented by an MHC molecule.
What kind of immunity involves nucleated cells processing endogenous antigens via MHC-1 molecules?
Cell mediated immunity.
What kind of antigens can be recognised by TCRs?
Only linear peptides.
What immune cells deal with infected cells?
Cytotoxic T cells.
What kind of immunity involves antibodies?
Humoral immunity.
