Flashcards in MHD - Lec #9 - Valvular Heart Disease Deck (12):
The haphazard pattern of myocyte organization and interstitial fibrosis is a hallmark of _____
What is the inheritance pattern of hypertrophic cardiomyopathy
Peripartum abnormalitites due to prolactin levels are often associated with what cardiomyopathy?
What proteins are affected by hypertrophic cardiomyopathy. (3)
Does this lead to a gain or loss of function?
1. β-myosin heavy chain i
2. myosin-binding protein C
3. troponin I/T.
Gain of function resulting in a hyper contractile state.
Mutations in these three genes account for 70% to 80% of all cases of HCM.
The diverse mutations underlying HCM have one unifying feature: they all affect sarcomeric proteins and increase myofilament activation.
Which of the following (dilated or hypertrophic cardiomyopathy) is due to 100% genetic causes?
What type of murmur is associated with hypertrophic cardiomyopathy?
Harsh systolic ejection murmur
Diastolic heart failure
Intractable heart failure
What is an amyloid?
Which cardiomyopathy is it associated with?
Misfolded protein --> BETA -PLEADED SHEET --> FIBRILS!
-Deposits in extracellular space
-Causes tissue damage
- LV normal but STIFF
- Left Atrium dilates due to stiffness of LV
- diastolic heart failure due to decreased filling
What are the 3 most common features of amyloid deposits, regardless of protein?
(Hint: when is it red, when is it green)
1. B-pleated sheet” configuration
2. Congo red staining in tissue
3.“apple-green” under polarized light
Infections with ______ are the most common etiology of myocarditis in the US
coxsackie A & B
Human immunodeficiency virus
What are some non-infectious causes of myocarditis?
1. Hypersensitivity reactions
2. Rheumatic fever
3.Giant cell myocarditis
What can myocarditis progress into?
-acute congestive heart failure
viral infection today, but no presentation for years
as the virus resolves there may be smoldering inflammation that goes on for years = DILATED CARDIOMYOPATHY
how do we know if coxsackie? (can find enteroviral particles in myocardium)