Micro Flashcards
(25 cards)
yellow fever
causes hepatitis following establishment of viremia
arbovirus transmitted by mosquitoes
structure hep A
picornaviridae
+ssRNA
resistant, acid stable
non-enveloped
structure hep B
hepadnaviridae
partially ds DNA
structure hep C
flaviviridae
+ssRNA
structure hep D
deltaviridae
ss circular RNA
structure hep E
hepeviridae
+ RNA
other viruses capable of causing hepatitis
EBV
CMV
HSV
Rubella (newborns)
clinical features hep A
children-mild
adults-more severe
spread and replication hep A
fecal oral
multiplies in GI tract causing viremia then to liver, kidney, spleen
lab diagnosis hep A
EM
anti HAV IgM
treatment hep A
pooled gamma globulin 1-2 weeks after exposure
hep A vaccine
inactivated Hep A
recommended for international travelers
two immunizations, first at a year, second 6 months later
only infectious particle hep B
Dane particle
Dane structure hep B
partial ds DNA
polymerase
surrounded by envelop
infectivity antigen
HBeAg
presence indicates infectious virus is present in patient
enzymatic function polymerase
DNAP
RT
RNase H-degrades RNA strand of RNA-DNA hybrid
replication Hep B
occurs in nucleus and cytoplasm
purpose viral RNA
messenger to be translated into proteins
template for viral genome DNA synthesis
lab diagnosis hep B
EIA and other antigen-Ab tests
liver biopsy for HbsAg in cytoplasm
blood bank test for HBsAg, anti-HBsAg and HBV DNA
Heptavax
preferred if person is allergic to yeast
not glycosylated when produced in yeast
treatment baby to mother with HBV
HBIG and vaccine ASAP
alpha interferon pegylated effective in severe cases
treatment chronic hep B
injectable interferon alpha
pegylated IF
oral nucleoside analog-lamivudine
nucleotide analog-adefovir, enticavir, telbivudine, tenofovir
treatment targets hep C
protease inhibitor
NS5A inhibitor
NS5B inhibitor
Hep D
requires HBV as helper
alpha IF temporary benefit
