Micro - Hemorrhagic Fevers Flashcards
(22 cards)
List African hemorrhagic fevers
- Ebola
- Marburg
List other hemorrhagic fevers
- Dengue fever
- Yellow fever
- Rift valley fever
What happens to T-cells
- T-cell apoptosis leading to reduced immunity
What happens to liver
Hepatic damage, resulting in reduced coagulation factors
What happens to MQ’s
Increased pro inflammatory cytokines, leading to VD, vascular leaking, and endothelial damage.
Reservoir hosts for Marburg and Ebola
Bats
Diagnosis of Marburg and Ebola
- Direct ( Viral Ag via ELISA or nuclei acid via PCR )
- Indirect Igm or IgG via ELISA
Prevention and treatment of Ebola and Marburg
- Supportive therapy like fluid and electrolytes, sometimes anticoagulants
- Vax for monkeys
Yellow fever is a member of
Flavirdae
Clinical picture of yellow fever
Mild : FAHM
Moderate : Jaundice & Renal problems
Sever : Hemorrhagic fever, Renal failure & black vomitous
Prevention and treatment of yellow fever
- Supportive therapy
- Mosquito control
- 17D yellow fever live attenuated vaccine
Dengue fever virus is a member of
Flavirdae
Reservoir host of Dengue fever
Man
About classic dengue fever
- FAHM
- Joint pain
- Myalgia
- Maculopapular rash
Clinical picture of dengue fever
- Classic dengue fever
- Dengue hemorrhagic fever
- Dengue shock syndrome
About dengue hemorrhagic fever
- Occurs after 2nd infection with another DEN - serotype
- Exaggerated immune response
- Can develop DSS
About dengue shock syndrome
- Skin hemorrhages like in petechiae and purpura
- pt develop thrombocytopenia and hemoconcentration
Diagnosis of dengue fever
- Direct via viral Ag via ELISA or PCR
Rift valley fever virus is a member of?
Bunya virdae
What does rift valley fever cause in sheep and cattle?
Hepatitis and abortion and death
Small % of patients in rift valley fever develop
- Retinitis
- Meningio-Encephalitis
- Hemorrhagic fever
Diagnosis of Rift valley fever is by
Direct : Viral Ag via ELISA or PCR
