MICRO PARA QUIZ 3 - Gen. Properties of Viruses/Pathogenesis and Control of Viral Diseases/PARVOVIRUS AND ADENOVIRUS

Question 1

All of the following are caused by Adenoviruses, except?

Glomerulonephritis
Gastroenteritis
Conjunctivitis
Pneumonia

Answer 1

Glomerulonephritis

Question 2

Effect of B19 parvovirus on fetus:

Hydrops fetalis
Pure red cell aplasia
Fifth Disease
Erythema Infectiosum

Answer 2

Hydrops fetalis

Question 3

What type of specimen would be most appropriate for detection of adenovirus types 40 and 41 infection?

Blood
Urine
Stool
Swab

Answer 3

Stool

Question 4

Bocavirus is detected in which of the following:

Respiratory secretion
Urine
Bone marrow
Fetal liver

Answer 4

Respiratory secretion

Question 5

A 5 yo male child had onset of cough, nasal congestion, fever, and sore throat for 2 days, you suspect that the etiologic agent is an Adenovirus, which specific group of Adenoviruses does the etiologic agent belong?

Group E
Group C
Group B
Group A

Answer 5

Group C

Question 6

Major sites of Parvovirus replication include:

fetal bone marrow
ALL blood cells
fetal liver
CNS

Answer 6

fetal liver

Question 7

Which among these blood type is at risk for acquiring Parvovirus B19 infection:

Duffy
Lewis
P
ABO

Answer 7

P

Question 8

Principal targets for human B19 parvovirus?

Immature cells in the erythroid series
Mature RBC
Platelets
Immature Leukocytes

Answer 8

Immature cells in the erythroid series

Question 9

Mode of Transmission of Parvovirus:

Vertical
Parenteral
Respiratory
All are correct

Answer 9

Respiratory

Question 10

a 30 yo G2P1 (1001) 19 weeks Age of Gestation, mother came into your clinic, showing signs and symptoms of Parvovirus B19 Infection, what is the probable outcome of her pregnancy:

Fetal demise
All are correct
Healthy baby
Baby will produce antibody against B19

Answer 10

Fetal demise

Question 11

Treatment of Adenoviruses infection:

None
Remdesivir
Azithromycin
Cefuroxime

Answer 11

None

Question 12

Property/ies of Adenoviruses:

Replication in the cytosol
RNA, linear, 26–45 kbp, protein bound to termini, infectious
With envelope
Adenoviruses replicate well only in cells of epithelial origin.

Answer 12

Adenoviruses replicate well only in cells of epithelial origin.

Question 13

TRUE of Erythema Infectiosum (Fifth Disease):

The incubation period is usually 4-5 weeks but may extend to 6 weeks.

Specific IgM antibodies appear about 15 days postinfection.

This erythematous illness is most common in children of early school age and occasionally affects adults. Fever and mild constitutional symptoms may accompany the rash, which has a typical “slapped cheek” appearance

All are correct

Answer 13

This erythematous illness is most common in children of early school age and occasionally affects adults. Fever and mild constitutional symptoms may accompany the rash, which has a typical “slapped cheek” appearance

Question 14

These serotypes of Adenoviruses are etiologically associated with infantile gastroenteritis

Serotypes 15 and 41
Serotypes 40 and 41
Serotypes 10 and 11
Serotypes 30 and 32

Answer 14

Serotypes 40 and 41

Question 15

Types of Adenoviruses that are found most often in bone marrow and renal transplant recipients.

Types 15 and 16
Types 11 and 12
Types 40 and 41
Types 34 and 35

Answer 15

Types 34 and 35 cc

Question 16

These are all enveloped DNA viruses except

Adenosexual roa dna virus
Herpes
Pox
Hepadna

Answer 16

Adenosexual roa dna virus

Question 17

Which of the following is a single stranded DNA virus

Pox
Parvo
Hepadna
Herpes

Answer 17

Parvo

Question 18

A member of Ebola with no mortality rate in humans and found in the Philippines

Ivy Coast
Reston
Zaire
Sudan

Answer 18

Reston

Question 19

Identical to Marburg virus but differ in the antigenecity

Ebola
Option 3
Lassa
Crimean Congo
Hanta

Answer 19

Ebola

Question 20

A DNA virus

Toga
Arena
Bunya
Hepadna

Answer 20

Hepadna

Question 21

Zika virus is a

Hepadna
Flavi
Picorna
Hepe

Answer 21

Flavi

Question 22

The most lethal human pathogen among Arena virus

Marburg
Lassa
All of the above
Rift valley

Answer 22

Lassa

Question 23

Which can inactivate Lassa Fever virus

Detergents
Gamma radiation
UV radiation
All of the above

Answer 23

All of the above

Question 24

An RNA virus of arthropod borne with 3 segments

Arena
Bunya
Flavi
Filo

Answer 24

Bunya

Question 25

Rabies virus is killed rapidly by exposure to : Sunlight All are correct cc Ultraviolet light Heat (1 hour at 50C)

Answer 25

All are correct cc

Question 26

The organ with the highest titers of virus is: Parotid gland Submandibular salivary gland CNS

Answer 26

Submaxillary salivary gland

Question 27

Pathognomonic for Rabies: Amyloid deposition Fear of water Salivation Negri body

Answer 27

Negri body

Question 28

Orthomyxoviruses viral transcription occurs in the: Cytoplasm Ribosomes Cell Nucleus

Answer 28

Nucleus

Question 29

benign epidermal tumor that occurs only in humans . The virus has not been transmitted to animals and has not been grown in tissue culture. Vaccinia virus Smallpox virus Molluscum contagiosum Variola major

Answer 29

Molluscum contagiosum

Question 30

The most important cause of lower respiratory tract illness in infants and young children: Parainfluenza virus Adenovirus Influenza virus Respiratory syncytial virus

Answer 30

Respiratory syncytial virus

Question 31

The etiologic agent of Bronchiolitis is: Respiratory syncytial virus Adenovirus Influenza virus Parainfluenza virus

Answer 31

Respiratory syncytial virus

Question 32

Which of the following is not a nucleic acid based testing for viruses? Nucleic acid amplification Strand displacement amplification Enzyme immunoassay Polymerase chain reaction

Answer 32

Enzyme immunoassay

Question 33

Prions are sensitive to which of the following: Dry heat Phenol Urea Formaldehyde

Answer 33

Phenol

Question 34

Which of the following are the contents of Viral transport medium (VTM) contains a buffered salt solution, protein and saccharide nutrients, pH indicator, and antibiotics to inhibit bacterial and fungal conta Protein and saccharide nutrients pH indicator and antibiotics All of the above Buffered salt solution

Answer 34

All of the above

Question 35

The primary host of Molluscum contagiosum: Sheep Monkeys Cow Human

Answer 35

Human

Question 36

This is linked to Infectious mononucleosis, nasopharyngeal carcinoma and Burkitt's lymphoma HSV-1 HSV-2 Varicella-Zoster Epstein -Barr virus

Answer 36

Epstein -Barr virus

Question 37

Epstein Barr Virus attaches to the C3d Receptor (CD21) on the surface NK B Null T

Answer 37

B

Question 38

Exanthem erythema infectiosum is caused by Parvovirus B19 Cytomegalovirus Rubella Herpes simplex

Answer 38

Parvovirus B19

Question 39

PB19 targets what cells Lymphoblasts Megakaryoblasts Erythroblasts All of the above

Answer 39

Erythroblasts

Question 40

RNA virus with Sandfly morphology Bunya Flavi Arena Filo

Answer 40

Bunya

Question 41

Marburg and Ebola are examples of Bunya Flavi Filo Arena

Answer 41

Filo

Question 42

Dengue virus is under the classification of what virus Flavi Filo Bunya Arena

Answer 42

Flavi

Question 43

These are all RNA viruses except Arena Adeno Bunya Delta

Answer 43

Adeno

Question 44

RNA viruses that replicate in the nucleus Delta Influenza and Retro Arena Bunya

Answer 44

Influenza and Retro

Question 45

Breakbone fever is caused by Hanta Dengue Chikungunya Ebola

Answer 45

Dengue

Question 46

Which among of the specimens is an acceptable specimen for various types of viruses as confirmation of immunohistochemistry (IHC )or a standalone diagnostic test? Formalin-fixed, paraffin-embedded (FFPE) tissue Ethanol fixed, paraffin embbedded tissue Fresh specimen All of the above

Answer 46

Formalin-fixed, paraffin-embedded (FFPE) tissue

Question 47

Molluscum contagiosum is caused by poxvirus poliovirus herpesvirus none of the choices

Answer 47

poxvirus

Question 48

In smallpox, lesions in the mouth tended to ulcerate and discharge virus at what day of illness? 6-9 days 10-14 days 1-5 days 1 month

Answer 48

6-9 days

Question 49

The incubation period of variola (smallpox) 1 month 10-14 days 1-5 days 6-9 days

Answer 49

10-14 days

Question 50

The natural reservoir of cowpox: Deer Rodents Cows Humans

Answer 50

Rodents

Question 51

It is an occupational disease of **sheep and goat handlers** facilitated by skin trauma. Smallpox virus Adenovirus Vaccinia virus Orf virus

Answer 51

Orf virus

Question 52

Replication site of Picornaviruses: Nucleus Ribosome Cytoplasm Host cell

Answer 52

Cytoplasm

Question 53

These are the largest and most complex of viruses infecting humans. Poxvirus Picornaviruses Coronaviruses Rhinoviruses

Answer 53

Poxvirus

Question 54

The primary host of Molluscum contagiosum: Sheep Monkeys Cow Human

Answer 54

Human

Question 55

The etiologic agent of smallpox? Yabapox Variola Vaccinia Orf

Answer 55

Variola

Question 56

The portal of entry of variola virus : Upper Respiratory Tract GI Tract Skin CNS

Answer 56

Upper Respiratory Tract

Question 57

After viral entry of the Variola virus, primary multiplication occurs in the: CNS Lymphoids Skin Reticuloendothelial system

Answer 57

Lymphoids

Question 58

The only RNA virus which is a double stranded Reovirus Retrovirus Picornavirus Arenavirus

Answer 58

Reovirus

Question 59

Hepatitis A is a Picornavirus Hepadna Flavivirus Hepevirus

Answer 59

Picornavirus

Question 60

These are the only DNA viruses that replicate in the cytoplasm Influenza viruses Adenoviruses Polyomaviruses Poxviruses

Answer 60

Poxviruses

Question 61

All RNA viruses are single stranded except Arenavirus Delta virus Bunyavirus Reovirus

Answer 61

Reovirus

Question 62

This RNA virus has 12 segment double strand. Adenovirus Reovirus Bunyavirus Orthomyxovirus

Answer 62

Reovirus

Question 63

Which of the following laboratory methods describes below in the diagnosis of viral infection? Polymerase chain reaction Serological detection of virus specific antibodies Next Generation sequencing Viral culture

Answer 63

Polymerase chain reaction

Question 64

Viral respiratory specimens are refrigerated for no longer than 48 hours 72 hours 1 week 3 days

Answer 64

72 hours

Question 65

Cary-Blair media transports what type of specimen? All of the above Stool Urine Respiratory

Answer 65

Stool

Question 66

bactericidal for many gram-positive and gram-negative bacteria, including many strains of Proteus, Serratia, and Pseudomonas. Ineffective against streptococci and Bacteroides species. Has been used in serious infections caused by gram-negative bacteria resistant to other drugs. Tobramycin Gentamicin Streptomycin Amikacin

Answer 66

Gentamicin

Question 67

The following are commonly used urinary antiseptics: Chloramphenicol Ampicillin Nalidixic acid Metronidazole

Answer 67

Nalidixic acid

Question 68

The assembly of the virus particle from the manufactured components is a complex process. Some of the particles are released from the cell by budding, but the majority of poxvirus particles transfer to another cell for further replication mutate to a more virulent virus remain within the host cell die

Answer 68

remain within the host cell

Question 69

Primary host of ORF Virus: Cow humans rodents Sheep

Answer 69

Sheep

Question 70

Replication site of Poxvirus: Mitochondria Golgi apparatus Cytoplasm Nucleus

Answer 70

Cytoplasm

Question 71

The portal of entry of variola virus: break in the skin ingestion mucous membranes of the upper respiratory tract All are correct

Answer 71

mucous membranes of the upper respiratory tract

Question 72

when the variola virus enters the body, all of the following will take place EXCEPT: NO EXCEPTION transient viremia and infection of reticuloendothelial cells throughout the body primary multiplication in the lymphoid tissue draining the site of entry a secondary phase of multiplication in those cells, leading to a secondary, more intense viremia; and the clinical disease.

Answer 72

NO EXCEPTION

Question 73

The etiologic agent of contagious pustular dermatitis or sore mouth infection. Tanapox Molluscum contagiosum Variola Orf virus infection

Answer 73

Orf virus infection

Question 74

How to diagnose Molluscum contagiosum? Electron Microscopy Clinical PCR Culture

Answer 74

Clinical

Question 75

Diagnosis Smallpox Tanapox Molluscum contagiosum Herpes infection

Answer 75

Molluscum contagiosum

Question 76

Natural host of Tanapox virus? Sheep Monkey Cow Human

Answer 76

Monkey

Question 77

The picornavirus replication cycle occurs in the: Endoplasmic Reticulum Nucleus Cytoplasm of cells Golgi apparatus

Answer 77

Cytoplasm of cells

Question 78

Diagnosis Cowpox Smallpox Molluscum contagiosum Chickenpox

Answer 78

Smallpox

Question 79

Diagnosis Smallpox Cowpox Molluscum contagiosum Chickenpox

Answer 79

Molluscum contagiosum

Question 80

Portal of entry of Poliovirus: Skin Mouth Respiratory GIT

Answer 80

Mouth

Question 81

transient inhabitants of the human alimentary tract and may be isolated from the throat or lower intestine Rhabdoviruses Rhinoviruses Adenoviruses Enteroviruses

Answer 81

Enteroviruses

Question 82

Virus associated with the respiratory tract and isolated chiefly from the nose and throat. Rhabdoviruses Adenoviruses Enteroviruses Rhinoviruses

Answer 82

Rhinoviruses

Question 83

Incubation period of Poliovirus: 1 month 7-14 days 1-5 days 21 days

Answer 83

7-14 days

Question 84

Most common form of Polio wherein the patient has only a minor illness, characterized by fever, malaise, drowsiness, headache, nausea, vomiting, constipation, and sore throat in various combinations. The patient recovers in few days. Mild disease Moderate disease Paralytic poliomyelitis Nonparalytic poliomyelitis

Answer 84

Mild disease

Question 85

The predominating complaint is flaccid paralysis. The amount of damage varies greatly. Maximal recovery usually occurs within 6 months, with residual paralysis lasting much longer. Moderate disease Paralytic poliomyelitis Mild disease Nonparalytic poliomyelitis

Answer 85

Paralytic poliomyelitis

Question 86

The incubation period of coxsackievirus infection 1-5 days 2-9 days more than 14 days 7-14 days

Answer 86

2-9 days

Question 87

This virus has been isolated from patients with Meningitis, encephalitis, and paralysis resembling poliomyelitis. Enterovirus 70 Enterovirus 69 Enterovirus 71 Enterovirus 72

Answer 87

Enterovirus 71

Question 88

In China, Hand-foot-and-mouth disease is caused by: Enterovirus 71 Enterovirus 72 Enterovirus 70 Enterovirus 69

Answer 88

Enterovirus 71

Question 89

TRUE of RHINOVIRUSES, EXCEPT: Replication is limited to the surface epithelium of the nasal mucosa. They are associated with the majority of acute asthma exacerbations ALL ARE CORRECT Virus enters via the upper respiratory tract

Answer 89

ALL ARE CORRECT

Question 90

emerged as a cause of severe hand-foot-and-mouth disease, sometimes followed by nail shedding group B coxsackieviruses Coxsackievirus A6 coxsackievirus A16 group C viruses

Answer 90

Coxsackievirus A6

Question 91

Rhinoviruses grow better at what temperature? 18C 22C 28C 33C

Answer 91

33C

Question 92

Most common manifestation/form of Poliovirus infection? The predominating complaint is flaccid paralysis resulting from lower motor neuron damage. A recrudescence of paralysis and muscle wasting has been observed in individuals decades after their experience with paralytic poliomyelitis. stiffness and pain in the back and neck. The disease lasts 2–10 days, and recovery is rapid and complete. The patient has only a minor illness, characterized by fever, malaise, drowsiness, headache, nausea, vomiting, constipation, and sore throat in various combinations. Recovery occurs in a few days.

Answer 92

The patient has only a minor illness, characterized by fever, malaise, drowsiness, headache, nausea, vomiting, constipation, and sore throat in various combinations. Recovery occurs in a few days.

Question 93

They are the most commonly recovered agents from people with mild upper respiratory illnesses. They are usually isolated from nasopharyngeal secretions but may also be found in throat and oral secretions. Rotaviruses Rhinoviruses Poxvirus Vaccinia virus

Answer 93

Rhinoviruses

Question 94

TRUE of poliovirus: Most strains will infect monkeys when inoculated directly into the brain or spinal cord Poliovirus does not require a primate-specific membrane receptor for infection, and the absence of this receptor on the surface of nonprimate cells makes them virus resistant. ALL are TRUE There are three antigenic types of polioviruses based on epitopes found in the P1, P2, and P3 proteins.

Answer 94

Most strains will infect monkeys when inoculated directly into the brain or spinal cord

Question 95

A 20 yo female present with abrupt onset of fever and stabbing chest pain which is preceded by malaise, headache, and anorexia. Based on the history, the chest pain was noted for more than a week now. There is also associated abdominal pain. What do you think is the etiologic agent? group D coxsackieviruses group C coxsackieviruses group A coxsackieviruses group B coxsackieviruses

Answer 95

group B coxsackieviruses

Question 96

chief cause of acute hemorrhagic conjunctivitis: group B coxsackieviruses Coxsackievirus A6 Enterovirus 70 coxsackievirus A16

Answer 96

Enterovirus 70

Question 97

sequelae of acute hemorrhagic conjunctivitis: sepsis None Blindness cataract formation

Answer 97

None ??

Question 98

Primary multiplication site of Poliovirus? Intestine Brain Mouth blood

Answer 98

Intestine

Question 99

which of the following elements prevents inactivation of Poliovirus? Iron sodium deoxycholate Magnesium ether

Answer 99

Magnesium

Question 100

PB19 targets what cells Lymphoblasts Megakaryoblasts Erythroblasts All of the above

Answer 100

Erythroblasts