Microbial Triggers to Sepsis Flashcards Preview

S&P - Immunology > Microbial Triggers to Sepsis > Flashcards

Flashcards in Microbial Triggers to Sepsis Deck (12):
1

How do bacteria attach to epithelia?

Non-specific electrostatic interactions
Tethering via projections “fimbriae” or pili
Attachment via special receptors on human cell surfaces
Internalisation into the epithelial cell

2

How do bacteria penetrate epithelial/endothelial barriers?

Artificial penetration- breach of epithelium
Entry into and through the cell
Transit in between cell layers

3

Response to meningococcal infection

Release of inflammatory mediators by human cells e.g. TNF, IL8
Recruitment of innate immune response

4

Clearance of Gram negative bacteria

Opsonisation
Complement activation
Chemotaxis of neutrophils

5

What receptor recognises staphylococcal infection?

Toll-like receptors

6

How do superantigens work?

It is not processed by APC but binds directly to MHC class 2 activating more T cells than a normal immune response ​

7

Streptococcus pyogenes evasion of immunity mechanisms

Anti-neutrophil strategies
Anti-opsonisation strategies
Toxins which interfere with immune responses e.g superantigens

8

Neisseria meningitides evasion of immunity mechanisms

Anti-complement/MAC strategies e.g Capsule

9

Staphylococcus aureus evasion of immunity mechanisms

Anti-neutrophil strategies
Anti-opsonisation strategies
Toxins which interfere with immune responses e.g superantigens

10

What produces the panton valentine leucocidin enzyme?

Staphylococcus aureus

11

What does Panton Valentine Leukocidin do?

Forms pores in neutrophils to kill them
I

12

Which toxins cause superantigen toxic shock and by which bacteria?

Staphylococcus aureus
Toxic shock syndrome toxin-1 (TSST-1), staph enterotoxin A, B, C (SEA, B, C)