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Flashcards in Microbio Random questions Deck (191):
1

Failure of isotype switching with recurrent bacterial sinus and lung infection

Selective IgA deficiency

2

Profound deficit of T cells; failure of development of thymus and parathyroids. Catch 22

Di George Syndrome

3

Inability to mount IgM response. Mutation in WASP gene. Thrombocytopenia, infections, eczema (tie a WASP)

Wiskott-Aldrich Syndrome

4

Autosomal recessive disease. Mutations in DNA repair enzymes. IgA deficiency

Ataxia-telangiectasia

5

Lack of NADPH oxidase activity

Chronic Granulomatous Diseae

6

Diagnostic test of CGD

Nitroblue tetrazolium test

7

Plastic bubble. X-linked defect in IL-2 receptors in T cells

Severe combined immunodeficiency

8

AR disease wherein there is failure of phagolysosomal fusion

Chediak-Higashi Syndrome

9

Staph aureus immunomodulators specific for white blood cells

Panton Valentin Leukocidin

10

Sequestered focus of osteomyelitis arising in the metaphyseal bone

Brodie abscess

11

Eponym of Staphylococcal scalded skin syndrome

Ritter Disease

12

Eponym of TEN

Lyell Disease

13

Pastia's lines is found where

Scarlet fever

14

Marantic endocarditis
Abdominal surgery

Group D streptococcus - E. Faecalis
Streptococcus bovis

15

Satellite phenomenon around S. Aureus colonies

Haemophilus influenzae

16

Pontiac Fever

Legionella Pneumophilia

17

Metallic green sheen appearance

E. Coli

18

Coma shaped, shooting star motility

Vibrio cholera

19

Food fingers feces flies

Shigella species

20

Most common cause of bacillary dysentery

Shigella sonnei or Duval's bacillus

21

Currant jelly sputum

Klebsiella pneumoniae

22

Very low levels of all immunoglobulins; absence of B cells

X-linked agammaglobulinemia
Or Bruton's Disease

23

Unilateral enlargement of the sternoclavicular portion of the clavicle leading to detachment

Higoumenakis sign

24

Influenza like symptoms few hours after receiving penicillin due to lysis of treponemes

Jarisch-Herxheimer reaction

25

Snowflake lesion in the chest Xray

Leptospirosis

26

Infectious form of chlamydia trachomatis. Enters via endocytosis

Elementary Body

27

Form of Chlamydia spp that replicates in cell by fission

Reticulate body

28

Round to oval cytoplasmic inclusion bodies near the nuclei of conjuctival epithelial cells in trachoma

Halberstadter - Prowazek inclusions

29

Striking tachypnea, characteristic paroxysmal cough present in neonatal pneumonia from chlamydial infection (atypical pneumonia)

Staccato cough

30

Bird Fancier's Disease

Psittacosis

31

Donovan bodies like safety pins. Beef red ulcer

Donovanosis

32

Unilateral enlargement of the sternoclavicular portion of the clavicle leading to detachment

Higoumenakis sign

33

Influenza like symptoms few hours after receiving penicillin due to lysis of treponemes

Jarisch-Herxheimer reaction

34

Snowflake lesion in the chest Xray

Leptospirosis

35

Infectious form of chlamydia trachomatis. Enters via endocytosis

Elementary Body

36

Form of Chlamydia spp that replicates in cell by fission

Reticulate body

37

Round to oval cytoplasmic inclusion bodies near the nuclei of conjuctival epithelial cells in trachoma (chlamydia trachomatis)

Halberstadter - Prowazek inclusions

38

Striking tachypnea, characteristic paroxysmal cough present in neonatal pneumonia from chlamydial infection (atypical pneumonia)

Staccato cough

39

Bird Fancier's Disease

Psittacosis

40

Donovan bodies like safety pins. Beef red ulcer

Donovanosis

41

Mites or chiggers

Orentia tsutsugamushi

42

Example of human prion disease

Creutzfeld - Jacob Disease, Kuru, Gerstmann straussler scheinker syndrome

43

Three obligate anaerobes

Actinomyces, bacteroides, clostridium

44

All exotoxins are heat labile except

Staphylococcal enterotoxin

45

All bacteria have cell walls composed of peptidoglycans except

Mycoplasma pneumoniae (sterol)

46

All gram positive bacteria have no endotoxin except

Listeria monocytogenes

47

All bacteria capsules are composed of polysaccharide except

Bacillus anthracis (polypeptide)

48

AR disease, mutation in integrins, delayed separation of umbilical cord of more than 10 days

Leukocyte adhesion deficiency/Lazy leukocyte disease

49

Causes the gold color of staph aureus

Staphyloxanthin

50

Causes epidermal separation in staph aurues

Exfoliatin

51

Superantigen jn staph aureus causing food poisoning

Enterotoxin

52

Superantigen leading to toxic shock syndrome

TSST-1

53

Causes marked necrosis of the skin and hemolysis

Alpha toxin

54

Separation occurs at the dermo-epidermal junction

TEN

55

Two bacteria that are positive PYR test

Group D enterococci
Streptococcus pyogenes

56

Degrades DNA in exudates or necrotic tissue

DNAse or streptodornase

57

Toxin that produces scarlet fever

Erythrogenic toxin

58

Protease that rapidly destroys tissue causing necrotizing fascitiis

Exotoxin B

59

Sandpaper rash, pastia's lines desquamation, strawberry tongue

Scarlet fever

60

SPECS

Jones criteria

61

St. Vito's dance is also known as

Sydenhams chorea in acute rheumatic fever

62

Congenital absence of spleen seen in post splenectomy patients

Ivermark sydrome

63

Box car shape
Medusa head morphology

Bacillus anthracis

64

Obtained from reheated rice

Bacillus cereus

65

Tennis like racket appearance

Clostridium tetani

66

Bulging cans, honey and household duat

Clostridium botulinum

67

Lecithinase gas forming, egg yolk

Clostridium perfringens

68

Pseumembranous colitis

Clostridium difficile

69

Chinese characters, curved or comma shaped, black colonies on tellurite

Corynebacterium diphtheria

70

Tumbling motility

Listeria monocytogenes

71

Woolsorter's disease

Bacillus anthracis

72

3 virulence factors of bacillus anthracis

Edema factor (EF)
Lethal factor (LF)
Protective antigen (PA)

73

2 spectrum of disease caused by bacillus anthracis

Cutaneous anthrax
Inhalation anthrax

74

Toxin of clostridium tetani

Tetanospasmin

75

Glycine is found where

Renshaw cells

76

Triad of Botulinum

Symmetric descending flaccid paralysis
Absence of fever
Intact sensorium

77

When babies ingest spores found in household dust or honey

Infant Botulism
Floppy Baby Syndrome

78

Ferments matlose and glucose
Kidney bean shaped
Disease of proximity esp in close quarters

N. Meningitides

79

Ferments glucose only

N. Gonorrhea

80

Late acting complement components (c5-c9) wherein MACs cannot be formed. What organism?

N. Meningitides

81

Severe form of meningococcemia characterized by high fever, shock, widespread purpura and adrenal insufficiency

Waterhouse friderichsen syndrome

82

Neiserria infection characterized by petechial rashes/purpura (purpura fulminans)

Meningococcemia

83

Usual co-infection with N. Meningitides

Chlamydia trachomatis

84

Perihepatitis
Violin string adhesions

Fitz hugh curtis syndrome

85

Other neiseriacaea that cause subacute bacterial endocarditis

HACEK

86

Coolant, airconditioning

Legionella pneumophilia

87

Gran negative coccobacillary rods that requires factor X (hemin) and V (NAD)

Haemophilus influenza

88

Reason why HiB affects children from 6 months to 1 year exclusively

Decline in maternal IgG and immature system

89

Cherry red Epiglottitis, thumb sign

Haemophilus influenza B

90

Etiology of LTB

Parainfluenza

91

Radiographic sign found in parainfluenza

Steeple sign

92

Toxin in bordetella responsible for damaging ciliated cells causing whooping cough

Tracheal cytotoxin

93

Best time to obtain culture in bordetella pertussis

1-2 weeks during the catarrhal stage

94

This organism inhibits phagolysosome fusion

Legionella pneumophilia

95

Endotoxin is its only sole virulence factor

Legionella pneumophilia

96

Mild flulike disease found in legionella

Pontiac fever

97

Three organisms causing atypical pneumonia

Chlamydia
Mycoplasma
Legionella

98

Three organism causing pulmonary hemorrhage

Woolsorters disease
Congenital syphilis
Weils syndrome

99

Antibiotics that causes pseudomembranous colitis (3)

Clindamycin
2nd and 3rd generation cephalosporins
Ampicillin

100

Transplacental transmission of listeria characterized by late miscarriage or birth, complicated by sepsis

Granulomatosis infantiseptica
Early onset neonatal listeriosis

101

Propels listeria through the membranes of one human cell to another

Actin rockets

102

Toxin in listeria that allows it to escape phagosomes

Listeriolysin

103

Interacts with E-cadherin on the surface of the cells (listeria)

Internalin

104

Unpasteurized milk: 3 organisms

Listeria
Brucella
Campylobacter jejuni

105

Infection of C. difficile can precipitate flare-ups of?

Ulcerative colitis

106

Pseudomembranous pharyngitis?

C. diphtheriae

107

Pseumembranous esophagitis

Candida albicans

108

Chinese character, club or comma shaped

C. diphtheriae

109

Metachromatic granules in corynebacterium diphtheria

Babes ernst granules
Volitin granules

110

ADP ribosylation
Beta prophage
Elongation factor 2
Metachromatic granules

C. diphtheriae

111

Tumbling motility
Narrow zone of beta hemolysis
Grows in cold temperature

Listeria

112

Toxin in c. perfringens which is a lecithinase that cleaves cell membrane

A toxin

113

Ingestion of cheese, unpasteurized milk products, cabbages and green leafy vegetables

Listeria monocytogenes

114

Pathogenic toxins and substances of e. Coli

Flagellum
Capsule (K)
Endotoxin (O)
Enterotoxins

115

Enterotoxin in e. Coli causing watery diarrhea

HST and HLT

116

Enterotoxin in e. Coli causing bloody diarrhea

Verotoxin (shiga-like toxin)

117

Causes of neonatal meningitis

B group streptococci (agalactiae)
E. Coli
L. Monocytogenes

118

Watery diarrhea of long duration mostly in infants and developing countries (pediatric and poor)

EHEC

119

Non lactose fermenting, produces H2S, with flagella

Salmonella spp

120

Non lactose fermenting, non H2S producing, nonmotile

Shigella spp

121

Typhoid fever is due to what toxin?

Vi capsular antigen

122

Where salmonella hides and becomes dormant

Gallbadder

123

Strain of salmonella that causes septicemia. Common in pts with sickle cell anemia

Salmonella choleraesuis

124

Shiga dysenteriae type 2

Schmitz bacillus

125

Shigella bodyii group C

Newcastle manchester bacillus

126

Species of vibrio in the human colon

V. Cholerae

127

Species of vibrio in saltwater

V. parahemolyticus and vulnificus

128

Pandemics caused by vibrio (species)

Vibrio cholerae 01 biotype El Tor

129

Toxin of vibrio that enhances attachment to the intestinal mucosa

Mucinase

130

Diseases associated with C. jejuni

GBS
Reiter's syndrome

131

Urease positive. Poorman's disease

H. Pylori

132

Extended spectrum beta lactamases acitivity in drug resistant strains. Urease positive. Currant jelly sputum

Klebsiella pneumoniae

133

Associated with struvite stones and staghorn calculi

Proteus mirabilis

134

Produces pyocyanin (blue green pigment) and a sweet grape like odor

Pseudomonas aeruginosa

135

Toxin in pseudomonas that cause tissue necrosis and inactivates EF-2

Exotoxin A

136

Toxin in pseudomonas that damages cilia and mucosal cells

Pyocyanin

137

Toxin in pseudomonas that causes hemoglobin breakdown

Verdoglobin

138

Green nail syndrome

Skin and soft tissue infection caused by pseudomonas

139

Mild form of typhoid

Shanghai fever

140

Anaerobic bacteria implicated during bowel trauma, perforation or surgery

Bacteroides fragilis

141

Undulating fever, transmitted via contaminated dairy or cows

Brucella abortis

142

Transmitted by rabbits

Francisella tularemia

143

Most virulent bacteria, bipolar rods resembling safety pins. Transmitted via ticks

Yersinia pestis

144

Colonies resembles butterfly with musty odor. Reservoir is cats or dogs

Pasteurella multocida

145

Exported repetitive protein which prevents phagosome lysosomal fusion (M. Tuberculosis)

Sulfatides

146

Most important virulent factor in TB preventing leukocyte migration

Cord factor
Trehalose dimycolate

147

Toxin in M. tuberculosis that elicits dekayed hypersensitivity

Tuberculin surface proteins

148

Subpleural granuloma in primary complex

Ghon's focus

149

Ghon's focus plus associated lymph node

Ghon's complex

150

Usually found in apices in reactivated tubeculosis

Simon's focus

151

Causes pulmonary disease in immunocompromised hosts (CD4

Mycobacterium avium intracellurare complex

152

(+) lepromin test

Tuberculoid leprosy

153

PE findings shows hard nontender swelling with sinus tract draining sulfur granules. Associated with local trauma like broken jaw or dental extraction. Bacteria?

Actinomyces israelli

154

Aerobic gram + rode with aerial hyphae manifests as mycetomas and lung and brain abscess (orange colonies)

Nocardia asteroides

155

Smallest free living organism. Only bacteria with cholesterol in cell membrane

Mycoplasma pneumoniae

156

Toll like receptor 2 protein responsible for attachment, inhibition of ciliary motion and necrosis (mycoplasma pneumoniae)

P1 adhesin

157

Walking pneumonia

Mycoplasma pneumoniae

158

Primary syphilis

Chancre

159

Caused chancroid

H. Ducreyi

160

Secondary syphilis

Condyloma lata

161

Tertiary syphilis

Gummas
Neurosyphilis
Tree bark appearance in histo

162

Tabes dorsalis (pupil)

Argyll robertsons pupil
Prostitute pupil

163

Characterized by saddle nose, hutchinson teeth and saber shins + pulmonary hemorrhage

Congenital syphilis

164

Hutchinson triad

Hutchinson teeth, deafness, keratitis

165

Largest medically important bacteria

Borrelia burgdorferi

166

Characteristic rash in borrelia

Erythema chronicum marginalis
Bulls eye rash

167

Relapsing fever because of programmed rearrangement

Borrelia recurrentis

168

Shepherd crook

Leptospira interrogans

169

Gold standard for leptospirosis

Leptospire microscopic agglutination test

170

Snowflake lesion in Xray

Pulmonary involvement in leptospirosis

171

Triad of weil's disease

Jaundice, bleeding, uremia

172

Round to oval cytoplasmic inclusion bodies near the nuclei of conjunctival epithelial cells in trachoma

Halberstadter prowazek inclusion

173

Cat scratch disease

Toxoplamosis

174

Forms morulae in cytoplasm of monocytes

Erhlichia caffensis

175

Clue cells

Bacterial vaginosis

176

Chancroid

Haemophilus ducreyi

177

Major membrane sterol of fungi

Ergosterol

178

Fungi that causes liver cancer due to aflatoxin

Aspergillus flavus

179

Inhalation of the spores of this fungi causes allergic bronchopulmonary aspergillosis

Aspergillus fumigatus

180

Ring worm

Dermatophytosis

181

Tinea mannum

Hands

182

Causes tinea versicolor

Malassezia furfur

183

Spaghetti and meatball appearance

Malasezzia furfur

184

Rose gardener disease, thorn prick

Sporothrix schenckii
Sporothricosis

185

Dimorphic, very common in filipinos, inhalation of arthrospores

Coccioides immitis

186

Grows in soil contaminated with bird droppings (starling bird) or bat guano. Closely mimics tuberculosis. Budding yeast inside macrophages

Histpolasma capsulatum

187

Dimorphic fungus. Round yeast with broad based bud

Blastomyces dermatitidis

188

Thick yeast with multiple buds in wheel configuration (mariner's wheel). Also known as Lutz splendore de almeida disease

Paracoccidiodes brasiliensis

189

Septate hyphae that form V shaped branches in acute angles

Aspergillus fumigatus

190

Fungus ball

Aspergilloma

191

Non septate hyphae with walls and branches at right angles

Rhizopus oryzae and Mucor spp.