Microbiology Flashcards Preview

CRRAB I - Week 1 > Microbiology > Flashcards

Flashcards in Microbiology Deck (20)
Loading flashcards...
0

Inflammation of the inner heart lining due to an infectious agent is called...

Infectious endocarditis

1

What are the most often infected valves for infectious endocarditis?

Mitral and aortic

2

Septic emboli often result in what clinical manifestation?

petechiae and splinter hemorrhages

3

What may you see in the eye of someone with infectious endocarditis?

Roth spots

4

What are the major Duke criteria for infectious endocarditis?

Positive blood culture
Evidence of endocardial involvement

5

What are the 5 minor Duke criteria?

1. Predisposition (heart condition or IV abuser)
2. Fever above 100.3
3. Vascular phenomena (petechiae, etc.)
4. Immunologic phenomena (Roth's spots, Osler's nodes, rheumatoid factor)
5. Microbiologic evidence not meeting major criteria

6

What proteins are used by Staph aureus to evade host defenses? What do they do?

Protein A: Binds Fc of Ig
Coagulase: Forms fibrin coat around organism
Hemolysins: Destroy RBC
Leukocidins: Destroy WBC

7

What virulence factors are associated with Staph Aureus invading deep into tissue? What do they do?

Hyaluronidase: Destroys connective tissue
Staphylokinase: Lyses clots
Lipase: Breaks down fat tissue

8

What is the most common endocardial infectious agent with a patient with mitral valve tissue damage?

Streptococcal viridans

9

What are the 3 most common infectious agents for endocarditis?

1. Staph aureus
2. Strep viridans
3. Enterococcus

10

What virulence factors do you worry about with an enterococcus infection?

Pili
Surface proteins
Hyaluronidases
Proteases

11

What two antibiotic groups are enterococci resistant to?

Penicillin, Carbapenems

12

Streptococcus pyogenes has six virulence factors. What are they and what do they do?

Streptokinase: converts plasminogen to plasmin
M protein: Prevents host phagocytosis
Hyaluronidase: destroys connective tissue
DNase: Digests DNA
Streptolysin S: Destroys WBC's
Streptolysin O: Destroys RBC's

13

In Rheumatic fever, what is the bacterial protein that is responsible for antibody formation? What do antibodies attack?

M protein
Meromyosin

14

How do you treat rheumatic fever?

Corticosteroids
Penicillin based antibiotics
Aspirin
Rest

15

What are the main causes of myocarditis?

Coxsackie virus B and adenovirus (children)

16

What receptor do coxsackie and adenovirus attack on the heart?

CAR (Coxsackie and Adenvirus) receptor

17

What infectious agents are responsible for pericarditis?

Coxsackie A and B, Echoviruses, Influenza

18

What causes RMSF?

Rickettsia rickettsii

19

What do you use to treat RMSF?

Doxy