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MicroPara Flashcards

1
Q

HIV protein that promotes CD4 degradation

A

Vpu

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2
Q

HIV protein: expression of viral structural protein

A

Rev

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3
Q

HIV protein: increases viral infectivity, activation of T-cells, downregulates CD-4 MHC class I

A

Nef

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4
Q

HIV protein: increase transport of viral preintegration complex into nucleus

A

Vpr

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5
Q

HIV protein: transactivation

A

Tat

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6
Q

Completely inactivate HIV

A

50% ethanol, 10% house bleach,
0.3% H2O2 - all for 10min at room temp
pH 1.0

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7
Q

Identified on culture on SDA at 25C

A

Dermatophytosis

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8
Q

Psychrophilic 15-20C
Mesophilic 30-37C
Thermophilic 50-60C

Most pathogenic to man?

A

Mesophilic

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9
Q

Cause of Pneumonia

Assoc.with atherosclerotic CAD
Host: Humans only
Dx: Serology
Tx: Macrolides, Tetracycline

A

Chlamydia Pneumoniae

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10
Q

Major cause of death in Rabies

A

Respi paralysis

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11
Q

Layers of Endospore

Outer to Inner

A
  1. Exosporium - fx unclear
  2. Coat - impermeability to antibacterial
  3. Cortex - spore germination, susc. to lysosyme autolysis
  4. Spore wall - peptidoglycan
  5. Core - calcium dipicolinate: heat resistance
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12
Q

Phases of Growth Curve

A
  1. Lag - zero growth
  2. Exponential - constant growth
  3. Max Stationary - zero growth
  4. Decline - negative rate
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13
Q

Medusa head appearance
Comma shaped outgrowth
High dose Cipro

A

Wool-sorter

Inhalational Anthrax

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14
Q

Staph aureus: form pores on WBC, causing cytolysis

A

Panton Valentin Leukocidin

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15
Q

PYR positive
Esculin positive
Can grow in 6.5% NaCl & bile
Subacute Endocarditis

A

Strep Bovis

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16
Q

Negri bodies in Rabies are commonly seen in:

Highest titers:

A

Purkinje cells of Cerebellum
Pyramidal cells of Hippocampus

Submaxillary gland

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17
Q

Groove sign

Multiple Painful Lymphadenopathies

A

Chlamydia trachomatis L1-L3

Lymphogranuloma venereum

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18
Q

Vesicle on posterior pharyngeal wall, Herpangina, Coxsackie A characteristics

A 
Single stranded RNA
Positive
Icosahedral
Nonenvelopes
Nonsegmented
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19
Q

Regan lowe medium

A

Bordatella (contains charcoal, blood and antibiotic)

Has replaced Bordet Gengou

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20
Q

Exposure to bird feces or bat guano in caves

Mimicker of TB along with
Paragonimiasis

A

Histoplasmosis

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21
Q

Exotoxin inactivates EF-2 which is involved in Protein Synthesis

A

Diphtheria

Production of toxin in culture is inhibited by iron in medium

Pseudomonas produces a similar toxin

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22
Q

Virus with fiber projecting from Penton bases

A

Adenoviruses

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23
Q

HIV entry into macrophages by binding of gp120 to

A

CCR5 (Chemokine receptor for Macrophage trophic strains of HIV)

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24
Q

Chemokine receptor for Lymphocyte trophic strains of HIV

A

CXCR4

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25
Fusion peptide of HIV
gp41 p7 - nucleocapsid p17 - mayrix protein
26
Reverse transcriptase is found in Retroviridae and:
Hepadna
27
Heat-stable exotoxin
Staph aureus exotoxin
28
Naked DNA viruses
PAPP Parvo Adeno Papilloma Polyoma
29
Naked RNA viruses
CPR Calici Picorna Reo
30
Envelope of Herpesvirus is derived from
Nuclear membrane
31
Enveloped virus are more heat- ?
More heat labile | More sensitive to ether solubilization
32
Occurs after 2-12 weeks ff exposure to cercariae
Katayama fever - Schistosoma Japonicum IH: Oncomelania hupensis quadrasi Adults reside in sup&inf mesenteric veins of SI vs S. mansoni - IMV of LI
33
``` Multiple ring enhancing lesions Crescent cells Tachyzoites initially Penetrate nerve cells & eye Multiply as bradyzoites to form cysts ```
Toxoplasmosis
34
Acquire virulence by intro of foreign genetic material via bacteriophage infection
Transduction
35
Lobar Pneumonia (consolidation with air bronchigram, involve multiple lung segments)
Strep Pneumo | Klebsiella
36
Bronchopneumonia (patchy infiltrates without air bronchogram)
Staph Aureus Strep Pyogenes Pseudomonas Anaerobes
37
Interstitial Pneumonia
Mycoplasma | Most viruses
38
DOC for N. gonorrhea
Ceftriaxone | + Doxy for coinfection w/Chlamydia
39
Methylene blue: Babes Ernst metachromatic granules
Corynebacterium
40
Systemic mycoses Southwestern USA fever & cough
Coccidiodomycosis | Double-walled spherule with endospores
41
Transpulmonary stage
Ascaris Ancylostoma Strongyloides Wuchereria
42
Influenza component: cleaves Sialic acid to release progeny virus from infected cell
Neuraminidase
43
Influenza component: binds cell surface receptors to initiate infection
Hemagglutinin
44
Capsular Swelling Test
Quellung (+) if encapsulated | Asplenic patients at risk
45
Most infectious stage in Tuspirina
Bordatella Pertussis Catarrhal stage (1-2 wks after infection) - Highest Bacteremia Rhinorrhea, Fever, Anorexia, Malaise
46
Complement deficiency predisposes to Pyogenic Infections
C3 deficiency
47
Confirmatory test for HIV
Western blot - Color reaction shows AB in serum after reacting to viral proteins displayed by acrylamide gel electrophoresis and transferred to nitrocellulose Northern - RNA Southern - DNA
48
Virulence factor of M. TB: inhibits fusion of lysosomes with bacilli-containing phagosomes within macrophage
Sulfatide, promotes intracellular survival
49
Prevents leukocyte migration, | Glycolipid molecule that influence the long and slender form. of M. TB
Cord factor
50
Enzyme for bacterial invasion to facilitate spread through subcu tissue
Collagenase or Hyaluronidase Others IgA protease - adherence to mucous mem Leukocidin - destroys neutrophils & macro Coagulase - accelerates fibrin clot
51
Relapsing fever
``` Borrelia - Relapsing fever as Legionella - Pontiac Japonicum - Katayama R. ricketsii - Rocky Mountain Spotted Coxiella - Q fever ```
52
Hand, Foot, Mouth Disease is caused by Coxsackie A16 or -
Enterovirus 71
53
DOC for Strongyloides. Ivermectin or -
Thiabendazole
54
Antigen used in RPR
Cardiolipin
55
Most specific antibody diagnosis for SLE
Anti-Sm
56
Acquired by eating raw snails
Echinostoma ilocanum
57
AntiPseudomonal drugs
Ceftazidime
58
Chancroid
Chancroid - Haemophilus Ducreyi Chancre - Primary Syphilis Condyloma Lata - Secondary Syphilis Condyloma Acuminata - HPV
59
Gram neg rod | Skin and bone infections assoc with human bites & clenched fist injuries
Eikenella corrodens
60
Progressive Multifocal Leukoencephalopathy
JC Polyoma Virus immunocompromised demyelinating disorder of brain sparing SC and optic nerve homonymous hemianopsia mental impairment ataxia
61
Diffuse Alveolar and Interstitial Pattern in Immunicompromised
PCP

PLE reviewer (3 decks)

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