MicroRNA and Cancer Flashcards
(11 cards)
What is the role of lin-4 and let-7 microRNAs?
Developmental timing
Which microRNAs are associated with neuronal cell fate?
miR-124 and miR-9
What is the role of miR-17~92 cluster and miR-21?
Cell proliferation
Which microRNAs are involved in metabolism regulation?
miR-33a/b, miR-375
What is the role of miR-15a/16?
Regulation of Cell division
Which microRNAs are linked to determining haematopoietic cell fate?
miR-155, miR-150
What was the first demonstration of microRNA involvement in cancer?
Chronic lymphocytic leukaemia (CLL)
A 30 kb deletion affecting miR-15 and miR-16 was noted in CLL.
In which types of cancer have quick findings of microRNA involvement been noted?
Colorectal cancer, aggressive B-cell leukaemias, lung cancer, lymphomas
Rapid findings indicate the role of microRNAs in these cancer types.
What is altered in B-cell lymphoma 2 (BCL2) related to microRNAs?
Expression of miRNA
What happens when the expression of a microRNA targeting an oncogene decreases?
Expression of the oncogene increases
This leads to increased cell division and cancer progression.
What occurs when the expression of a microRNA that targets a tumor suppressor increases?
Expression of the tumor suppressor decreases
This also results in increased cell division and cancer development.
