Mid Term Quiz

Question 1

Less than 1 part

Answer 1

Very soluble

Question 2

1 to 10 parts

Answer 2

Freely soluble

Question 3

10 to 30 parts

Answer 3

Soluble

Question 4

30 to 100 parts

Answer 4

Sparingly soluble

Question 5

100 to 1000 parts

Answer 5

Slightly soluble

Question 6

1000 to 10000 parts

Answer 6

Very slightly soluble

Question 7

More than 10 000 parts

Answer 7

Practically insoluble

Question 8

What are the factors influencing solubility of a solute in a solvent?

Answer 8

Pressure
Temperature
The nature of the solute
pH of the medium

Question 9

Changes in pressure have most affect on what?

Answer 9

Gas

Question 10

Pressure increases…

Answer 10

Solubility increases

Question 11

What is salting out phenomenon?

Answer 11

Adding sugar to the gaseous beverages will cause the release of the gas and the liquid to outside of the bottle

Question 12

What happens to the solubility of a gas in a liquid when temperature increases?

Answer 12

Generally Solubility decreases

Question 13

What happens to the solubility of a solid in a liquid when temperature increases?

Answer 13

Generally Solubility increase

Question 14

Examples of polar solvents

Answer 14

Water, glycols, methyl and ethyl alcohol

Question 15

What do polar solvents dissolve?

Answer 15

Ionic solutes and the polar substances

Question 16

What are the structural features that the solubility of substances in polar solvents depend?

Answer 16

Question 17

Non polar solvents are unable to do what?

Answer 17

Reduce the attraction between the ions due to their low dielectric constants

Question 18

They are unable to form hydrogen bonds with….

Answer 18

Non-electrolytes

Question 19

Non-polar solvents can dissolve non-polar solutes through what ?

Answer 19

Weak vander waals forces

Question 20

Example of non-polar solvent

Answer 20

Solutions of oils

Question 21

What are semi-polar solvents?

Answer 21

Question 22

Seme-polar solvents can at as what?

Answer 22

Intermediate solvent to bring about the missibility of polar and non polar liquids

Question 23

As the pH increase what happens to solubility of acidic drugs ?

Answer 23

Solubility increases

Question 24

What is the pH equation for the acidic drugs

Answer 24

Question 25

As the pH decreases what happens to solubility of basic drugs?

Answer 25

Solubility increases

Question 26

What is the pH equation for basic drugs?

Answer 26

Question 27

What is the Noyes-Whitney equation ?

Answer 27

Question 28

What are factors that are directly proportional to the rate?

Answer 28

Area Diffusion coefficient Concentration gradient

Question 29

What improves bioavailability?

Answer 29

Griseofulvin Digoxin Tetracycline

Question 30

How to increase surface area

Answer 30

Reducing particle size

Question 31

How can you reduce particle size?

Answer 31

Mortar and pestle Mechanical grinders Fluid energy mills Solid dispersions in readily soluble materials (PEG’s)

Question 32

What will reduce the thickness?

Answer 32

Agitation

Question 33

What does diffusion coefficient depend on?

Answer 33

Size of the molecule Viscosity Temperature

Question 34

How does particle size affect diffusion coefficient?

Answer 34

Particle size increases the diffusion coefficient decrease

Question 35

How does viscosity affect diffusion coefficient?

Answer 35

Viscosity increases the diffuser coefficient decreases

Question 36

How does temperature affect diffusion coefficient?

Answer 36

Temperature increases diffusion coefficient increases

Question 37

In general the compounds solubility increases...

Answer 37

Dissolution rate increases

Question 38

What is sink conditions?

Answer 38

When Cb is much smaller than Cs so Cb is canceled from the equation