Midterm - Hemoglobin

Question 1

iron-bearing protein contained within the erythrocytes

Answer 1

Hemoglobin

Question 2

Primary hemoglobin molecule

Answer 2

Amino acid sequence

Question 3

secondary hemoglobin molecule

Answer 3

helices & Non helices

Question 4

tertiary hemoglobin molecule

Answer 4

Pretzel like configuration

Question 5

Quaternary hemoglobin molecule

Answer 5

Complete molecule

Question 6

COMPOSITION OF HEME

Answer 6

• Protophorphyrin IX
• Ferrous iron (Fe2+)

Question 7

Heme synthesis first takes place in?

Answer 7

Mitochondria

Question 8

the ability of hemoglobin to bind
or release oxygen

Answer 8

Oxygen Affinity

Question 9

Bohr Effect

Answer 9

relationship of O2 affinity with Hb to pH

Question 10

141 amino acid

Answer 10

• Alpha
• Zeta

Question 11

straight line

Answer 11

sigmoid curve

Question 12

Right shift

Answer 12

• Inc. Temp
• Inc. 2-3 DPG
• Inc. Hydrogen conc.

Question 13

Left Shift

Answer 13

• dec. temp
• dec. 2-3 DPG
• dec. Hydrogen & CO

Question 14

Hemoglobin in combination with Oxygen. Gives pinkness to the skin and mucous membrane

Answer 14

Oxyhemoglobin

Question 15

hemoglobin with iron but no O2 seen in venous circulation
unassociated with oxygen

Answer 15

Deoxyhemoglobin

Question 16

Found in normal human embryos and fetuses with a
gestational age of less than three months

Answer 16

Embryonic Hemoglobin

Question 17

Composed of 2 zeta and 2 epsilon globin chains

Answer 17

Hemoglobin Gower I

Question 18

Composed of 2 alpha and 2 epsilon

Answer 18

Hemoglobin Gower 2

Question 19

composed of 2 zeta and 2 gamma

Answer 19

Hemoglobin Portland

Question 20

the major hemoglobin of the fetus and newborns

Answer 20

Fetal Hemoglobin (HbF)

Question 21

normal adult hemoglobin
* 95 to 97 % of hemoglobin in normal adults produced after
one year onwards
* composed of 2 alpha (141 AA) and 2 beta chains(146 AA

Answer 21

Hemoglobin A or A1

Question 22

Constitutes less than 3% of the total hemoglobin
* Composed of 2 alpha and 2 delta

Answer 22

Hemoglobin A2

Question 23

• degradation product of HbA2
• composed of 2 alpha and 2 delta

Answer 23

Hemoglobin A3

Question 24

primary hemoglobin in people with sickle cell
disease

Answer 24

Hemoglobin S

Question 25

Glutamic acid is replaced by valine in the 6th position of beta chain * SGAVAL

Answer 25

Hemoglobin S

Question 26

Hemoglobin C

Answer 26

* CGAL

Question 27

About 2-3% of people of West African descent are heterozygotes for hemoglobin C

Answer 27

Hemoglobin C

Question 28

one of the most common beta-chain hemoglobin variants in the world.

Answer 28

Hemoglobin E

Question 29

an abnormal hemoglobin that occurs in some cases of alpha thalassemia.

Answer 29

Hemoglobin H

Question 30

Are acquired hemoglobin variants whose structure has been modified by drugs or environmental chemicals.

Answer 30

CHEMICALLY MODIFIED HEMOGLOBINS

Question 31

* Is a form hgb in its ferric state * Has a brownish to bluish color and does not revert to red on exposure to oxygen.

Answer 31

Methemoglobin (HI)

Question 32

Results from the binding of carbon monoxide to heme iron. * Hb can combine with carbon monoxide with affinity 200-240 times greater than that of Oxygen.

Answer 32

Carboxyhemoglobin

Question 33

Sulfhemoglobin

Answer 33

irreversible oxidation of Hb of certain drugs and chemicals.