Midterm (SSL) Flashcards

(56 cards)

1
Q

What percentage of Americans have a sliding hiatal hernia?

A

40 % of American have a sliding hiatal hernia

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2
Q

What differentiates hiatal hernia (HH) from hiatal hernia syndrome (HHS)?

A

A Hiatal Hernia Diagnostic can be seen on imaging by doing a CT scan or a Barium swallow.

Worst=Ultrasound

A HH Syndromes done by correlating symptoms to functional tests without it showing on imaging.

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3
Q

Although biomedicine considers most sliding hiatal hernias to be asymptomatic, this pathology causes many symptoms. Know the common symptoms, diagnosis and treatment of hiatal hernia and HHS.

A

Allopathic Med;
Hiatal Hernia = Asx.
GERD like Sx’s.
Big enough = Arrythmias & shallow breathing.

Naturopathic medicine Sx’s:
Fatigue, anxiety and mental dullness. 
Non-cardiac chest pain  
Arrhythmias like atrial fibrillation
Shallow breathing 
Chest oppression 
Stitching pain, 
tickling cough 
pallor

Reflux regurgitation & pallor & flatulence.

Tx.: Visceral manipulation, visceral breathing

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4
Q

What is the relationship between spinal levels and hiatal hernia syndrome?

A

Spinal levels T10-T11 and bilateral down occiput.

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5
Q

What are the various options for determining if a patient has hypochlorhydria?

A
  • Heidelberg testing – definitive
  • Gastric String Test – Screening
  • Ridler’s Gastric Acid Point – functional
  • Clinical Picture
  • Billateral PEC minor weakness
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6
Q

What is the relationship between hypochlorhydria and gastroparesis? How could gastroparesis be life-threatening?

A

If there is not an appropriates acidity the bolus will take a while to proceed which can lead to gastroparesis and subsequent more complicated situations.

DM1=life Threatening

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7
Q

How does the temperature of food and drink affect orocecal transit time?

A

Cool food slow it

Hot foods stimulate motility

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8
Q

What is the explanation for reflux causing symptoms (including heartburn) if a patient has hypochlorhydria?

A

Duodenal contents reflux back into the stomach causing pain.

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9
Q

What are the available treatments for hypochlorhydria?

A

Bitter Herbs or Vinegar 20 minutes before the meal
Betaine Hydrochloride with pepsin
B12 Folate supplementation

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10
Q

Ulcers that perforate into the peritoneal cavity unchecked by adhesions are usually located in what region of the Stomach?

A

anterior wall of the duodenum

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11
Q

What are the sx/signs that change in the intermediate phase of perforated peptic ulcer that might incorrectly cause you to think that the patient’s condition is improving and that a surgical consult is not needed?

A

1st stage- 2 hrs-rigid, sev. abd. pain

stage 2 (Intermediate)- 2-12 hr “reactionary stage’- may seem like pt is ok again, vomiting stops, pain dec. abd still rigid.

3 stage-peritonitis, pulse inc. vomiting, distention, hypotension

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12
Q

What is the finding found on percussion of the abdomen that is highly correlated with perforated peptic ulcer?

A

Percussion : Liver = “tympanic” (Obliterated) (meaning free air in peritoneum)

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13
Q

To what location is pain referred from a perforated peptic ulcer?

A

Refers to one or both shoulders

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14
Q

What is the finding on a plain x-ray film that is a highly likely sign of a perforated peptic ulcer (80-85% of cases are positive for this?)

A

Diagnosis is confirmed if an x‑ray or CT shows free air under the diaphragm or in the peritoneal cavity. Upright views of the chest and abdomen are preferred. The most sensitive view is the lateral x‑ray of the chest. Severely ill patients may be unable to sit upright and should have a lateral decubitus x‑ray of the abdomen.

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15
Q

Summarize the prevention of dysplasia and adenocarcinoma of the esophagus in patients with long segment Barrett esophagus

A

Increased intakes of vegetables and fruit are associated with a lower risk of BE in men and women.
Treat the cause of ongoing GERD
PPI’s? (Proton Pump Inhibitors)
Incr. fruits and vegetables
Treat SIBO if present to prevent excess deconjugation of bile salts
Use berry extract and/or retinoids
Curcumin or other herbal COX-2 inhibitors
Selenium
Green tea catechins
Ursodeoxycholic acid-The cytoprotective hydrophilic bile acid glycoursodeoxycholic acid (UDCA) prevents DNA damage, cytotoxicity, and ROS.

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16
Q

What is NERD? What are dilated intercellular spaces? What is DGER?

A

NERD-Nonerosive Reflux disorder, it’s a reflux that will shows no abnormalities on imaging.

DGER-Duodenogastro esophageal reflux and it’s when the the duodenal contents reflux back into the stomach.

Dilation of intercellular spaces = early morphological marker in gastro-esophageal reflux.

Easily visible intercellular bridges:
Irregular round or diffuse widening

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17
Q

Understand the spectrum of GERD including NERD, erosive and non-erosive esophagitis, Barrett esophagus, dysplasia and adenocarcinoma.

A

If you have either GERD or DGER and you use PPI’s=>

Low stomach acid=>dilated intercellular spaces=>persistent heartburn symptoms.

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18
Q

What are the components of the mnemonic – “cut out the CRAP?”

A
C = Coffee, Cigarettes, chocolates
R = Refined carbohydrates
A = Acid foods, allergic foods, alcohol
P = Pop soda, peppermint, packin foods, progesterone
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19
Q

Know the most distal site that may be assessed by upper endoscopy (EGD), that H. pylori status will be assessed and that celiac disease biopsies are performed with this procedure (not colonoscopy.)

A

Esophagogastroduodenoscopy (EGD) visualizes the throat through the second portion of the duodenum. Sample can be taken for H. pylori. Can asses for barret’s metaplasia and dysplasia or adenocarcinoma.

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20
Q

Discuss why H. pylori screening of patients who do not have sx of PUD may lead to unnecessary treatment

A

The symptoms of GERD are very similar to the Symptoms of H.Pylori

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21
Q

What cause of GERD might be managed with phosphatidylcholine and Huperzine A?

A

To improve tone of the sphincter, mucosal health and GI motility use:

        	- Phosphatidylcholine 420 mg BID
        	- if insufficient use add huperizine 50 mg BID
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22
Q

Why might both hyperchlorhydria and hypochlorhydria cause pyrosis?

A

Hyperchloridia can cause pyrosis by the obvious action of burning the esophagus with the excess acid
Hypochloridia - Failure to digest foods properly. This will result in a general malabsorption of proteins.
hypochlorhydria -> undigested food -> gas, distention, delayed gastric emptying -> pressure on LES -> reflux enters esoph. -> pyrosis

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23
Q

List the effect of the following on gastric acid levels:

A

a) H. pylori pangastritis – hypo/a - chloridia
b) H. pylori antral gastritis - hyperchloridia
c) early (first 3 months) of any H. pylori gastritis – Hypochlorydia because the H. pylori secretes an alkaline compound called ureasa to protect itself from the Stomach acid which can lead to hypochloridia in the early stages.

24
Q

Know the mnemonic PATELLA and the typical order of symptoms in acute appendicitis

A

Pain
Anorexia, N and/or V
Tenderness (Rovsin sign as well as Mcburney’s)
Elevated Temp
Leukocytosis 14k-17k, 80k+->Leukemia rxn (Kids)
Lying Still-(Peritoneal irritation)
Asleep-Intense abd. pain
Typical Order of Sx
Pain, usually epigastric or umbilical
Anorexia, N/V
Tenderness, somewhere in abdomen or pelvis
Fever
Leukocytosis

25
Be familiar with the ascending, pelvic and retrocecal appendicitis presentations. How are they different from the typical iliac appendicitis? Know that the temp is less than 102.5 before perforation.
Be familiar with the ascending (QL is irritated), pelvic (rectal exam tender on rt side (-psoas & rigidity) and retrocecal appendicitis presentations (No local pain, may contact it thru the rectum, little Mm rxn). How are they different from the typical iliac appendicitis (The classic history of anorexia and periumbilical pain followed by nausea, right lower quadrant (RLQ) pain, and vomiting occurs in only 50% of cases. Vomiting that precedes pain is suggestive of intestinal obstruction)? Know that the temp is less than 102.5 before perforation. (can go as high as 104.5 after perforation) Ascending Presentation
26
Know how functional testing is used to check for open and closed ileocecal valve syndrome. Know that right lower quadrant pain, dizziness, chronic right shoulder problems and tinnitus are possible sx. Know that adrenal imbalances and lack of adequate calcium may be causes.
Muscle Testing Iliacus – open ileocecal valve Quadriceps – closed ileocecal valve
27
Know the function of the appendix.
Vestigial- (400 + species of commensal flora storage)
28
Know the three homeopathic remedies discussed for acute appendicitis.
Bryonia – throbbing, sharp or stitching pain which is worse from slightest motion, may feel better lying on the painful side, and dry mucous membranes with thirst for larger amounts at infrequent intervals. Emotionally irritable; wants to be left alone Belladonna – early stage with violent cramping, squeezing or throbbing pain and fever, worse slightest touch (even the pressure of the covers) or any sudden movement. Pain may start and end suddenly. Patient lies supine. Maybe thirstless. Red hot face, dilated pupils (Delirious, sleep w/eye open) Iris tenax – a near specific for appendicitis and for pain in the ileocecal region after adhesions from appendicitis – also if you are unsure of dx. 10x
29
Understand why acute appendicitis usually causes constipation.
Cecum irritated->tightens ICV->leads to constipation
30
Know that acute salpingitis and ectopic pregnancy are important differentials in women with sx/signs of appendicitis. Know that mesenteric lymphadenitis may mimic acute appendicitis in children.
Acute Salpingitis – inflammation of the ovarian tubes Mesenteric lymphadenitis – lymph nodes that become inflamed in the mesenteric area. (Mimics Acute appendicitis) Imaging-plain x-ray, (not good) Ultrasound (compress=flat neg, stays enlarged= +, helical CT = most accurate
31
How are Crohn and ulcerative colitis differentiated (see chart)?
``` UC Cramping pain, lower abd, relieved by BM Bloody stool No abdominal mass Affects only colon Mucosal disease Continuous from rectum Crohn Constant pain, RLQ, no relieved by BM Stool not usually grossly bloody Abdominal mass, often in RLQ May affect small, large, bowel; rarely esophagus and stomach Transmural disease, granulomas in some Effects all layers Skip area ```
32
What is indeterminate colitis?
IC is the 10-15% of cases of IBD in which there was difficulty distinguishing bn UC and CD in the colectomy specimen. DX is based on endoscopic, histologic and radiologic findings, when CD and UC can not be definitively established.
33
What are the two forms of microscopic colitis and why are they called microscopic?
Inflammation of the colon that causes persistent water diarrhea. The disorder gets it’s name from the fact that it’s necessary to examine colon tissue under the microscope to identify it. Collagenous colitis – thick layer of protein (collagen) develops in colon tissue Lymphcytic colitis – in which lymphocytes increase in colon tissue. Not sure whether both are two separate disorders or represent different phases of the same condition.
34
Understand the difference between ulcerative proctitis and more widespread UC including pancolitis (risk of colon cancer, location). Know that it can often be seen on an anuscopic exam. Know the sequelae of UC in general (toxic megacolon, systemic effects)
Ulcerative Proctitis Idiopathic mucosal inflammatory disease involving only the rectum and is therefore an antomically limited form of UC. Dx based on clinica presenation, endoscopic appearance, and histopathology Can be sometimes seen with anuscopic exam Most people diagnosed with ulcerative colitis are concerned they will develop colon cancer, but this is rare. The lifetime incidence of colon cancer is 2.5% at 10 years, 7.6% at 30 years, and 10.8% at 50 years. Those at higher risk for cancer have a positive family history of colon cancer, long durations of colitis, extensive colon involvement, and primary sclerosing cholangitis, a complication of ulcerative colitis.
35
Understand the locations of Crohn disease (ileitis, Crohn colitis) and its sequelae in general (transmural thickening leading to obstruction of the terminal ileum, systemic effects.)
Crohn can be anywhere along the GI tract including the mouth and esophagus. Early mucosal involvement consists of longitudinal and transverse aphthous ulcerations, which are responsible for the cobble stone appearance. With progression, deep fissures, sinuses and fistulas develop. Inflammation involves all layers of the intestinal wall, which becomes thick patchy distribution with areas of normal bowel (skip) Complications: intestinal obstruction, fistula (can cause indolent abcess), perforation and hemorrhage (rare due to thickened mucosa) Locations: Ileum and colon 45% Ileum alone 35% Colon alone 20% Entire small bowel (jejunoileitis) Systemic effects: fatigue, weight loss, fat malabsorption (increase risk of gallstones, renal oxalate stones), steatorrhea, constipation from obstruction, distension, vomiting, hyperhomocysteinemia, Sequelae includes transmural thickening leading to obstruction of the terminal ileum.
36
Know the anatomical limits of EGD and colonoscopy. Know which type of endoscopy is used to biopsy for Celiac disease. Know which is used to definitively diagnose IBD.
Rectum and colon are the limit for colonoscopy. Colonoscopy with biopsy for IBD Celiac – small bowel biopsy is confirmatory – esophagogastroduodenoscopy (EGD)
37
Know the common sx/signs of UC and Crohn.
Crohn Fatigue, wt loss, may be fever. Abdominal pain RLQ Occult blood is common, blood in stool if colonic involvement but less then UC Stool usually formed maybe loose if extensive colonic involvement or terminal ileum (from bile salt malabsorption) Steatorrhea Fat malabsorption – increase risk of gallstones Obstruction: severe colic, abd. Distension, constipation, vomiting UC – range from mild to severe Cramping abdominal pain Series of attacks of bloody diearrhea with asx intervals Blood and mucus in stool Stools may be normal or hard. If UC extends proximal – stool becomes looser (watery with mucus and blood) Systemic – malaise, fever, anemia, wt. loss Complications: hemorrhage, and toxic megacolon
38
Know the lab tests that may help in the diagnosis of IBD and its differentiation from IBS. Know that IBD is considered to be autoimmune.
Crohn CBC (slight anemia, leukocytosis) ESR elevated CRP elevated Low serum iron, low vit B12 + fecal lysozyme (inflammation marker) ANCA Fecal Calprotectin (can replace a lot of colonocscopies) Other IBD serology markers UC CBC – anemia, high platelet count ESR and CRP elevated CMP – hypoalbuminemia, hypokalemia, hypomagnesemia, elevated alk phos IBD serology markers IBS No physical signs to definitively diagnose IBS Rome Criteria – abdominal discomfort lasting at least 12 weeks (don’t have to be consecutive), and two of the following: change in frequency or consistency of stool, straining urgency or feeling like you can’t empty your bowels completely, mucus in stool, bloating or abdominal distension. Labs – Lactose intolerance test, Blood test to rule out Celiac and IBD.
39
Be familiar with dietary, nutritional supplements and botanicals in the treatment of IBD.
Crohn Dr. Lawton’s Crohn General Formula Dr. Lawton’s Acute Crohn Formula (Chamomilla, Foeniculum, Kalmerite, Viburnum, Valerian, Belladonna) Curcuma Inhibitory effects on cyclooxygenases, li[pxgenase, TNF-alpha, interferon gamma, NF-kappaB Antioxidant 360mg 3-4/day reduced clinical relapse in patients with quiescent IBD Bowellia serrate 3600mg/day compared to 4500mg/day mesalamine found no statistical difference in improvement of Crohn activity index over an 8 week period. Diet and Combination Nutraceuticals in Juvenile Crohn Exclude: Dairy, corn, whole grain, any products containing carrageenan (food thickener) Netruaceuticals Small-chain fish peptides and amino acids in ratio 60:40 (Intensive) Dairy free colostrum Boswellia serrate taken 30 min before meals. Curcumin taken with each meal Multivitamin/mineral supplement taken with breakfast and dinner Culturelle – probiotic preparation containing 10 billion cells of Lactobacillus GG. 2x/week Resutls: within 2 months of starting DNT all six patients went into remission with discontinuation of all pharm drugs. Three patients have remained in sustained remission for 4-8 years ** SSL diet recommendation is the Specific Carbohydrate Diet. Smoking doubles the risk for CD – so quit Elimination diet UC Boswellic serrata Inhibit activation of NFkappaB Down regulates TNF-alpha, IL-1/2/4/6, and IFN-gamma Stabilize mast cells Inhibits 5 LOX, decreasing leukotriene levels 550mg TID was more effective than sulfasalazine in controlled trials. (remission rate 82%) Aloe vera 3oz 2x/day for 4 weeks.. remission superior to placebo in double blind Yarnell’s UC Relaps Prevention Formula (achillea, astragalus, curcuma, calendula, hypericum, propolis, gentian, ceanothus) 1tsp TID Salmon 600 gm/week improve severity improve anti-inflam fatty acid index decreased levels of CRP decreased levels of homocysteine Fish oil supplementation Studies show no benefit – inconclusive Retarded release phosphatidylcholine (rPC) Creates a pH dependent release in distal ileum Mucus from the colon of UC patients is deficient in PC and adding to the mucus has anti-inflam effects VSL#3 probiotic/Human probiotic infusion
40
Antibodies to distinguish Chrons from UC?
UC - ANCA / Chrons - ASCA
41
Medications that reduces Folate from the blood is?
Mesalanine
42
Supplements that have long and short term effects with medications to treat IBD?
Specific Carbohydrate diet
43
Lab test to distinguish IBS from IBD?
Fecal Calprotectin
44
54 y/o with pain in RLQ and string sign in imaging and diharrhea?
Chrons Disease
45
What are the three key symptoms/signs of IBS?
Relieved with defecation; and/or Onset associated with a change in frequency of stool; and/or Onset associated with a change in form (appearance) of stool.
46
How does the menstrual cycle and post-menopausal status affect IBS symptoms?
Sex hormones may also play a role in the pathogenesis of irritable bowel syndrome (IBS). This is supported by observations that more women suffer from IBS than men,and that premenopausal female patients often report exacerbation of their symptoms at the time of menses and have fewer episodes of abdominal bloating than postmenopausal women. Furthermore, postmenopausal women taking hormone replacement therapy (HRT) experience less bloating than those not taking HRT. IBS most prevalent during menstruation years… more common in F than M sxs most severe: postovulatory and premenstrual maybe dt increased progesterone levels abd bloating after menopause
47
What stool tests may reveal infectious etiologies for IBS?
fecal WBC’s, O&P, Culture? ``` (PI-IBS bugs: campylobacter, salmonella, shigella, e. coli, viruses, giardia) remember CDT (cytolethal distending toxin) .. pacemaker cells (interstitial cells of Cajal) of the MMC of the small bowel are destroyed… remember, Vinculin.. looks like CDT so our body makes autoantibodies ```
48
What are the alarm signs (red flags) in IBS?
1. symptom onset after age 50 2. severe, unrelenting diarrhea 3. nocturnal symptoms 4. unintentional weight loss 5. hematochezia (GI BLEEDING) 6. FmHx of colorectal CA
49
What non-invasive tests are used to determine the need for colonoscopy to rule out more serious diagnoses in patients with IBS-like sx?
hydrogen/methane breath testing to dx SIBO (stool not used for SIBO) blood tests: CBC, ESR, CV, KD, thyroid NOT SURE!!!
50
What are seven clinical indicators that increase the chances of SIBO being the etiology for IBS?
after antibiotic tx, sxs dramatically improve after probiotics, sxs are worse eating more fiber increases constipation and other sxs when a “celiac pt” sxs do not improve after a gluten-free diet after taking opiates, pt develops IBS-C (C = constipation type) pt has chronic low ferritin level w no apparent cause imaging reveals large gas bubble obscuring the pancreas small bowel follow-through imaging reveals areas of “flocculation”
51
List the physiological mechanisms by which bacterial overgrowth is normally prevented?
ST acid, pancreatic enzymes, bile in the duodenum pH > 3 … overgrowth in ST and SI likely a working well Ileocecal Valve SI motility via migrating motor complex normal glycocalyx and microvillus of brush border (avoid carb malabs. and fuel for bugs) don’t drink booze, don’t use PPI’s
52
Briefly describe the typical effects of H2 and CH4 on gastrointestinal motility.
Methane: CONSTIPATION… methane stinky constipated poo constipation or alternating constipation and diarrhea slow GI motility Hydrogen: DIARRHEA usu IBS-D (diarrhea type) increases GI motility
53
Which gas produced by SIBO is associated with increasing symptoms of fibromyalgia?
HYDROGEN?
54
What is the likely mechanism by which SIBO leads to fat soluble vitamin deficiencies?
damage to SI -> digestive & absoptive fx bugs make glycosidase which damages glycoclyx or disaccharidases >> deconjugation of bile >> fat malabs, steatorrhea, fat-soluble Vit deficiencies >>> this can also lead to more carb malabs and leaky gut
55
What are the four main categories of treatment for SIBO?
Diet (SCD, low-FODMAPS) Herbal Antibiotics (FC-Cidal w Dysbiocide OR Candibactin-AR w Candibactin-BR) (garlic, oregano, neem, berberine) Antibiotics (Rifaximin for H2, Rifaximin + Neomycin for CH4) Promotility agents (erythromycin stimulates Migrating Motor Complex, MMC) or LDN or Prucalopride can add a Biofilm Disruptor like NAC Elemental Diet (AA, fat, vitamins, minerals, rapidly absorbed carbs)
56
Discuss the mechanism of action and use of enteric coated menthol for IBS
antibacterial effect decreases pain, spasms smooth muscle relaxant side effect: GERD