Midterms

Question 0

FC in FC fragment?

Answer 0

Fragment crystallizable

Question 1

Glycoproteins found in the serum portion of the blood?

Answer 1

Immunoglobulins

Question 3

Humoral branch of immune response?

Answer 3

Immunoglobulins

Question 4

Fab?

Answer 4

Antigen Binding Fragment

Question 5

L chains found in the urine of patients with multiple myeloma?

Answer 5

Bence-Jones Proteins

Question 6

Two main types of L chains

Answer 6

Kappa (2) & Lambda (22)

Question 7

A unique amino acid sequence that is common to all immunoglobulin molecules
A heavy chain that determines Ig class.

Answer 7

Isotype

Question 8

Variation in constant region of both HC & LC.

Present in some individuals but not in others.

Answer 8

Allotype

Question 9

Variation in variable region of both HC & LC.

Unique to a specific antibody molecule.

Answer 9

Idiotype

Question 10

Region for flexibility which contains proline?

Answer 10

Hinge region

Question 11

Extra heavy chain?

Answer 11

CH4

Question 12

Heavy chain of IgG?
IgA?
IgM?
IgD?
IgE?

Answer 12

Gamma
Alpha
Mu
Delta
Epsilon

Question 13

Good polymer?

Answer 13

IgM

Question 14

Smallest, coating antibody, associated with secondary immune response?

Answer 14

IgG

Question 15

Provide immunity for newborns?

Answer 15

IgG

Question 16

IgG best compliment fixer?

Answer 16

IgG3

Question 17

1st to be produced after antigenic stimulation

Answer 17

IgM

Question 18

Major antibody for secretions

Answer 18

IgA

Question 19

IgA type for serum? For secretions?

Answer 19

IgA1, IgA2

Question 20

Ig for immunoregulation & found on surface of B cells

Answer 20

IgD

Question 21

Ig that has affinity to basophils and mast cells

Answer 21

IgE

Question 22

Reduction of Antibody (2)

Answer 22

2-mercaptoethanol

Dithiothreitol

Question 23

Cut monomer into 3 parts exactly at the hinge region

Answer 23

Papain

Question 24

Cut monomer below hinge region into 2 parts

Answer 24

Pepsin

Question 25

Unrelated cytokines? - Endogenous pyrogens? - T cell growth factor? - Stimulates B cells?

Answer 25

Interleukins - IL1 - IL2 - IL6

Question 26

``` Interfere in viral replication. Proteins produced by virally infected cells and protect neighboring cells. Which type is: -non specific? -consists of? -specific? -consists of? ```

Answer 26

``` Interferons Type 1 -Alpha (leukocytes) -Beta (fibroblast) Type 2 -Gamma (t cells) ```

Question 27

Cytotoxic activity against tumor cells and virally infected cells. Which type is produced by macrophages? By CD41 & CD8 cells?

Answer 27

Tumor Necrosis Factors TNF alpha TNF beta

Question 28

Enhances motility and promote migrations of WBC | Also known as chemotaxin

Answer 28

Chemokines

Question 29

Released by platelets during coagulation

Answer 29

Betalysin

Question 30

A set of proteins that play a role in cytolytic destruction of cellular antigens by specific antibody

Answer 30

Complement system

Question 31

Order of discovery

Answer 31

C123456789

Question 32

Order of activation via classical pathway

Answer 32

C142356789

Question 33

Membrane attack complex (MAC)? | Final MAC?

Answer 33

56789 | 9

Question 34

Heaviest because of its tri-molecular complex? Components of complex? What attaches these complexes together?

Answer 34

C1 Q, R, S Calcium

Question 35

Which complement proteins are not synthesized in the liver?

Answer 35

``` C1 (intestinal epithelial cell) Factor D (adipose) ```

Question 36

``` Specific pathway which is initiated by IgG & IgM? Recognition unit? Activation unit? MAC? Electrolyte? ```

Answer 36

Classical pathway C1 C4, C2, C3 C5-C9

Question 37

C3 convertase?

Answer 37

C4b2a

Question 38

C5 convertase?

Answer 38

C4b2a3b

Question 39

Non-specific pathway/bypass pathway which is initiated by igA & activates factor D? What is properdin pathway? Electrolyte?

Answer 39

Alternative pathway Stabilizer of C3 convertase Magnesium

Question 40

Pathway with no C1, mannose instead Recognition unit? Electrolyte? Activation unit?

Answer 40

Lecitin pathway MASP -1-2-3 complex C5 convertase (C3b4b2a)

Question 41

Inhibitors of MAC

Answer 41

Homologous Restriction Factor

Question 42

MIRL/CD59?

Answer 42

Membrane Inhibitor of Reactive Lysis