Miini Quizz Flashcards
(10 cards)
Which antidepressant is known for having the lowest risk of sexual side effects?
Bupropion (Wellbutrin)
Bupropion is even used to reverse SSRI sexual side effects.
Clozapine is often combined with which medication to reduce seizure risk, especially at high doses?
Depakote (Valproate)
Depakote is used with Clozapine to mitigate seizure risk when doses increase.
Which condition is the FDA black box warning for Clozapine?
Agranulocytosis
This warning is part of the REMS program requirement for Clozapine.
Which side effect affects 30–80% of patients taking Clozapine?
Sialorrhea
Clozapine can cause intense drooling in a significant number of patients.
During the first 6 months of Clozapine treatment, how often must ANC labs be checked?
Weekly
ANC monitoring is weekly for the first 6 months, then every 2 weeks for the next 6 months, and monthly thereafter if stable.
Why is Depakote sometimes added when patients are prescribed Clozapine?
To prevent seizures
Depakote helps stabilize mood and addresses Clozapine-induced seizure threshold reduction.
Which SNRI is most associated with increased blood pressure at higher doses?
Venlafaxine
Venlafaxine can increase blood pressure at doses exceeding 150 mg.
Which class of medications should be used cautiously with SNRIs due to serotonin syndrome risk?
MAOIs
Combining SNRIs with MAOIs poses a significant risk for serotonin syndrome.
Which SNRI is FDA-approved to treat diabetic peripheral neuropathy and fibromyalgia, in addition to depression?
Duloxetine (Cymbalta)
Duloxetine is approved for multiple conditions including depression and anxiety.
What is the main risk when combining tamoxifen with a CYP2D6 inhibitor like fluoxetine (Prozac)?
Tamoxifen is not converted to its active form
Fluoxetine inhibits CYP2D6, preventing tamoxifen from becoming its active anti-cancer metabolite.
