Mini 2 Flashcards

1
Q

Toxin: Benzodiazapines
Antidote:

A

Flumazenil

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2
Q

Selective antagonist of 𝛼2

A

Yohimbine (NOT USED!!!)

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3
Q

All blood vessels
Receptor type:
Receptor response when active:

A

Receptor type: β2

Receptor response when active: Vasodilation

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4
Q

Toxin: Aspirin/ salicylate toxicity
Toxic Metabolite:
Antidote:

A

Toxic Metabolite: Uncoupling of OxPhos in mitochondria

Antidote: Gut Decontamination, gastric lavage; activated charcoal; IV fluids; IV BiCarb

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5
Q

Nicotinic receptors

A

Nn
Nm

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6
Q

Selective antagonist of β1

A

Atenolol
Metroprol

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7
Q

Toxin: CO
Antidote:

A

100% O2

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8
Q

Path from Tyrosine to NE

A

Tyrosine - DOPA via Tyrosine Hydroxylase (RATE LIMITING STEP!)
DOPA to Dopamine
Dopamine to NE
NE to Epi

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9
Q

Heart - SA Node
Receptor type:
Receptor response when active:

A

Receptor type: β1

Receptor response when active: Increased HR

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10
Q

Toxin: Irritant gases (Chlorine, ammonia, sulfur, NO)
Antidote:

A

Humidified O2
Bronchodilators

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11
Q

Toxin: Lead
Chealator:

A

Edetate Calcium Disodium Ethylenediamintetraacetic acid (EDTA)

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12
Q

Affects on Adrenergic Receptors:
Inhibits Uptake 1 at nerve terminal

A

Cocaine
Imiparamine

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13
Q

Selective agonist of 𝛼2

A

Clonidine

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14
Q

Site: Arterioles
Predominant Tone:

A

Sympathetic - cholinergic

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15
Q

Coronary Vasculature
Receptor type:
Receptor response when active:

A

Receptor type: D1

Receptor response when active: Vasodilation

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16
Q

Skeletal Muscles
Receptor type:
Receptor response when active:

A

Receptor type: β2

Receptor response when active: Increase glycogenolysis (contractility)

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17
Q

Kidney
Receptor type:
Receptor response when active:

A

Receptor type: β1

Receptor response when active: Increased Renin release

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18
Q

Male Sex Organs
Receptor type:
Receptor response when active:

A

Receptor type: 𝛼1

Receptor response when active: Ejaculation of vas deferens

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19
Q

Radial muscle of eye
Receptor type:
Receptor response when active:

A

Receptor type: 𝛼1

Receptor response when active: Contraction

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20
Q

Toxin: Copper
Chealator:

A

Penicillamine

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21
Q

Heart AV Node
Receptor type:
Receptor response when active:

A

Receptor type: β1

Receptor response when active: Increased conduction

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22
Q

Toxin: CO
Antidote:

A

Oxygen

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23
Q

Toxin: Mushroom poisoning (muscarinic excessive symptoms)
Antidote:

A

Atrophine

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24
Q

Affects on Presynaptic Parasympathetic Cholinergic Transmission:
Inhibit release of ACh

A

Botulinum Toxin (anticholinergic)

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25
Antagonists of Nm receptors
Hexamethonium Mecamylamine
26
Toxin: Delirium due to anticholinergic agents Antidote:
Physostigmine
27
Selective agonist of β2
Albuterol Terbutaline
28
Toxin: Oxidizing Agents Antidote:
Methylene Blue
29
Affects on Presynaptic Parasympathetic Cholinergic Transmission: Inhibit Vesicular Storage of ACh
Vesamicol (anticholinergic)
30
Toxin: Cyanide Antidote:
Hydroxycobalamin
31
Uterus Receptor type: Receptor response when active:
Receptor type: β2 Receptor response when active: Relaxation
32
Bronchioles Receptor type: Receptor response when active:
Receptor type: β2 Receptor response when active: Dilation
33
Affects on Adrenergic Receptors: Inhibits NE placement within vesicles
Amphetamines Tyramine
34
Enzymes involved in termination of ACh
Acetylcholinesterase Butyrylcholinesterase
35
Toxin: B-blockers Antidote:
Glucagon
36
Site: Sweat Glands Predominant Tone:
Sympathetic - cholinergic
37
Toxin: Theophylline, caffeine, metaproterenol Antidote:
Esmolol
38
Prejunctional nerve terminal Receptor type: Receptor response when active:
Receptor type: 𝛼2 Receptor response when active: Decreased NR release and NE synthesis
39
Selective agonist of β1
Dobutamine
40
Site: Veins Predominant Tone:
Sympathetic - cholinergic
41
Selective agonist of 𝛼1
Phenylephrine
42
Toxin: Cyanide Antidote:
Nitrites - induce methemoglobinemia Thiosulfate - converts cyanide to Thiocyanate
43
Toxin: Digoxin; cardiac glycosides Antidote:
Digoxin Abs
44
Toxin: Iron Chealator:
Deferoxamine Deferasirox
45
Toxin: Iron salts Antidote:
Deferoxamine
46
Heart - AV muscles Receptor type: Receptor response when active:
Receptor type: β1 Receptor response when active: Increased contraction
47
Affects on Presynaptic Parasympathetic Cholinergic Transmission: Promote release of ACh
Latrotoxin (spider venom) (cholinergic)
48
Rate Limiting Enzyme of ACh synthesis
Choline Acetyltransferase
49
Heteroreceptors
Resides on nerve cell Sensitive to NT's/Hormones released by other cells
50
Antagonist of Nn receptors
Tubocurarine Atracurium
51
Affects on Presynaptic Parasympathetic Cholinergic Transmission: Anticholinesterases
Neostigmine (favors cholingeric receptors)
52
Toxin: Anticholinesterase Intoxication Antidote:
Atrophine
53
Trigone/Sphincter of Urethra Receptor type: Receptor response when active:
Receptor type: 𝛼1 Receptor response when active: Contraction (urinary retention)
54
Selective antagonist of β2
Butoxamine (NOT USED!!!)
55
Affects on Presynaptic Parasympathetic Cholinergic Transmission: Inhibit Choline Carrier
Hemicholinium (anticholinergic)
56
Enzymes used to metabolize NE
Monoamine oxidase Catechol-O-methyl transferase
57
Liver Receptor type: Receptor response when active:
Receptor type: 𝛼1 Receptor response when active: Increased glycogenolysis
58
NE synthesized from
Tyrosine
59
Toxin: Fluoride/Ca2+ channel blockers Antidote:
Calcium
60
Kidney Receptor type: Receptor response when active:
Receptor type: 𝛼1 Receptor response when active: Decreased Renin secretion
61
Toxin: Mercury Chealator:
Succimer (dimercaptosuccinic acid)
62
Toxin: Organophosphates; Cholinesterase inhibitors Antidote:
Pralidoxime (2-PAM)
63
Site: Iris Predominant Tone:
Parasympathetic - cholingergic
64
Arterioles of skin/viscera Receptor type: Receptor response when active:
Receptor type: 𝛼1 Receptor response when active: Contraction = increase BP
65
Veins Receptor type: Receptor response when active:
Receptor type: 𝛼1 Receptor response when active: Contraction = increase preload
66
Selective antagonist of 𝛼1
Prazosin
67
Platelets Receptor type: Receptor response when active:
Receptor type: 𝛼2 Receptor response when active: Platelet aggregation
68
Site: Salivary Glands Predominant Tone:
Parasympathetic - cholingergic
69
Affects on Adrenergic Receptors: Inhibits release of NE from vesicle
Bretylium Guanethidine
70
Toxin: Narcotic drugs Antidote:
Naloxone
71
Toxin: Hydrogen sulfide Antidote:
No specific treatment Recommend Nitrites
72
Renal vasculature Receptor type: Receptor response when active:
Receptor type: D1 Receptor response when active: Vasodilation
73
Pancreas Receptor type: Receptor response when active:
Receptor type: 𝛼2 Receptor response when active: Decrease Insulin secretion
74
Heart - His/Purkinje fibers Receptor type: Receptor response when active:
Receptor type: β1 Receptor response when active: Increased automaticity/Conduction
75
Toxin: Acetaminophen Toxic Metabolite: Antidote:
Toxic Metabolite: N-acetyl-p-benzoquinone imine NAPQI Antidote: n-acetylcysteine (NAC)
76
Site: Ciliary Muscle of eye Predominant Tone:
Parasympathetic - cholingergic
77
Autoreceptors
Resides on nerve cell Sensitive to NT/hormones released BY neuron where autoreceptor sits
78
Toxin: Lead Chealator:
Succimer (Dimercaptosuccinic acid)
79
Site: GIT Predominant Tone:
Parasympathetic - cholingergic
80
Affects on Adrenergic Receptors: Interfere with synthesis of NE
Metyrosine
81
Site: Heart Predominant Tone:
Parasympathetic - cholingergic
82
Toxin: Mentanol/ethylene glycol Antidote:
Ethanol Fomepizole
83
Affects on Adrenergic Receptors: Inhibits Storage/Uptake of NE
Resperine
84
Site: Genital Tract Predominant Tone:
Sympathetic AND Parasympathetic
85
Liver Receptor type: Receptor response when active:
Receptor type: β2 Receptor response when active: Increase glycogenolysis
86
Toxin: Tricyclic antidepressants Antidote:
Sodium Bicarbonate
87
Site: Bladder Predominant Tone:
Parasympathetic - cholingergic
88
Mesenteric vasculature Receptor type: Receptor response when active:
Receptor type: D1 Receptor response when active: Vasodilation
89
Pancreas Receptor type: Receptor response when active:
Receptor type: β2 Receptor response when active: Increase Insulin Secretion