Question 1

``` Pre-miRNA is processed to miRNA by which enzyme: A. RNA protease B. Dicer C. DNA protease D. mRNA ligase E. Donner ```

Accepted Answer

B -- Dicer

Question 2

``` The complement component binds to what portion of the B-cell receptor complex to generate Signal 2 which promotes B cell activation? A. CD 21 B. IgM C. CD 28 D. CD 4 E. CD 3 ```

Accepted Answer

A -- CD21

Question 3

Which cytokines induce the proliferation of T-helper 17 (TH17) cells? 1. IFN-gamma 2. IL-4 3. TGF-beta 4. IL-6 5. IL-12 ``` A. 1 and 4 B. 1 and 3 C. 3 and 4 D. 2 and 3 E. 1 and 5 ```

Accepted Answer

C -- 3 and 4

Question 4

``` Phosphorylation of RB protein is mediated by which complex? A. Cyclin B-CDK1 B. Cyclin A-CDK1 C. Cyclin A-CDK2 D. Cyclin E-CDK1 E. Cyclin D-CDK6 ```

Accepted Answer

E -- Cyclin D/CDK6

Question 5

All are ligands for toll-like receptor 2 (TLR2) EXCEPT: ``` A. Zymosan B. Peptidoglycan C. Lipoarabinomannon D. Double-stranded RNA E. Phosphatidylinositol dimannoside ```

Accepted Answer

D -- dsRNA

Question 6

T lymphocyte anergy can be mediated by blocking IL-2 production when B7 is bound by which molecule? ``` A. CTLA-4 B. CD28 C. CD3 D. CCL2 E. SHPS-1 ```

Accepted Answer

A -- CTLA-4

Question 7

Glanzmann's thrombasthenia is caused by mutation of a Calcium- binding domain of: ``` A. GPIb B. GPIa C. GPIIb D. GPIIa E. GPIIIb ```

Accepted Answer

C -- GPIIb

Question 8

All are true for platlet activating factor (PAF) EXCEPT:

A. Produced by mast cells
B. Inhibited by PAF acetylhydrolase
C. Is a product of cycylooxygenase enzymes
D. Lysophosphatdylcholine is an intermediate form
E. Is derived from cytoplasmic phospholipase A2 activity

Accepted Answer

C -- is a product of COX

Question 9

Which increases in sepsis? ``` A. Plasminogen-activator inhibitor 1 B. Tissue factor-pathway inhibitor C. Antithrombin III D. Protein C E. Protein S ```

Accepted Answer

A -- PAI-1

Question 10

All of the following help induce endothelial proliferation except: ``` A. Hypoxia B. TGF-beta C. PDGF D. Endostatin E. TGF-alpha ```

Accepted Answer

D -- endostatin

Question 11

Which of the following point within the cell cycle is responsible for monitoring the integrity of DNA prior to replication: ``` A. G0 phase B. G1/S checkpoint C. G2 D. G2/M checkpoint E. M phase ```

Accepted Answer

B -- G1/S checkpoint

Question 12

Basophils lack which of the following: ``` A. Heparin B. Histamine C. LTC4 D. LTD4 E. LTE4 ```

Accepted Answer

A -- heparin

Question 13

All of the following are true concerning Delta-like ligand 4, EXCEPT: ``` A. It is expressed in arteries B. It is expressed in capillaries C. It is expressed in veins D. It interacts with NOTCH E. Blockade of Delta-like ligand 4 results in increased vessel sprouting ```

Accepted Answer

C -- expressed in veins

Question 14

``` The alternative pathway within the complement cascade is activated by: A. IgG B. IgM C. IgE D. Mannose-binding lectin E. LPS ```

Accepted Answer

E -- LPS

Question 15

Gradual cooling of the cadaver is referred to as: ``` A. Livor mortis B. Algor mortis C. Rigor mortis D. Softening E. Anthropogenic cooling ```

Accepted Answer

B -- algor mortis

Mini-Board 2011 Flashcards

(27 cards)