Mini Exam 3 Flashcards by nikta nasri

estradiol brand name

Estrace

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estradiol drug class

Estrogen derivative

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estradiol indication

breast cancer, metastatic; hypoestrogenism (female); osteoporosis prevention (female); prostate cancer, advanced; menopausal symptoms

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estradiol target

estrogen receptor

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estradiol target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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estradiol target normal role

as a homodimeric nuclear receptor, in the un-bound state, monomers of the receptor are sequestered in the cytoplasm by large chaperone protein complexes. upon binding of a ligand the receptor undergoes a conformational change which results in dissociation of the receptor from its chaperone proteins, nuclear localization, dimerization, DNA binding, and association with co-transcription factor, ultimately resulting in upregulation of genes involved in the development and maintenance of primary and secondary sex characteristics in biologic females

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estradiol pharmacologic activity

agonist

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conjugated equine estrogens brand name

Premarin

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conjugated equine estrogens drug class

estrogen derivative

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conjugated equine estrogens indication

metastatic breast cancer, female hypoestrogenism, female osteoporosis prevention, advanced prostate cancer, menopausal symptoms

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conjugated equine estrogens target

estrogen receptor

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conjugated equine estrogens target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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conjugated equine estrogens pharmacologic activity

agonist

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ethinyl estradiol/ etonogestrel brand name

EluRyng; NuvaRing

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ethinyl estradiol/ etonogestrel drug class

contraceptive; estrogen and progestin combination

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ethinyl estradiol/ etonogestrel indication

contraception

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etonogestrel target

progesterone and estrogen receptor

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etonogestrel target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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etonogestrel pharmacologic activity

agonist

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norgestimate brand name

Sprintec, Esarylla

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norgetimate drug class

contraceptive; estrogen and progestin combination

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norgestimate indication

contraception

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norgestimate target

progesterone and estrogen receptor

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norgestimate target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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norgestimate pharmacologic activity

agonist

drospirenone brand name

Yasmin, Jasmiel

drospirenone drug class

contraceptive; estrogen and progestin combination

drospirenone indicaion

contraception

drospirenone target

progesterone and estrogen receptor

drospirenone target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

drospirenone pharmacologic activity

agonist

norethindrone/ ferrous fumarate brand name

Lo Loestrin Fe

norethindrone class

contraceptive; estrogen and progestin combination

norethindrone indication

contraception

norethindrone target

progesterone and estrogen receptor

norethindrone target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

norethindrone pharmacologic activity

agonist

levonorgestrel brand name

N/A

levonorgestrel class

contraceptive; progestin

levonorgestrel indication

emergency contraception

levonorgestrel target

progesterone receptor

levonorgestrel target family and location

steroid nuclear receptor expressed in various tissue types

raloxifene brand name

Evista

raloxifene class

selective estrogen receptor modulator (SERM)

raloxifene indication

prevention and treatment of bone loss after menopause

raloxifene target

estrogen receptor

raloxifene target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

raloxifene pharmacologic activity

agonist/antagonist

raloxifene MOA

it acts like an estrogen agonist in the bone to prevent bone loss and has estrogen antagonist activity to block some estrogen effects in the breast and uterine tissues. raloxifene decreases bone resorption, increasing bone mineral density and decreasing fracture incidence

testosterone brand name

Androderm

testosterone class

Androgen

testosterone indication

delayed puberty; hypogonadism

testosterone target

androgen receptor

testosterone target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

testosterone pharmacologic activity

agonist

bicalutamide brand name

Casodex

bicalutamide class

antineoplastic agent, antiandrogen

bicalutamide indication

metastatic prostate cancer

bicalutamide target

androgen receptor

bicalutamide target family and location

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

bicalutamide pharmacologic activity

reversible, orthosteric antagonist

levothyroxine brand name

Synthroid

insulin aspart brand

Novolog

insulin aspart class

insulin, rapid-acting

insulin aspart indication

T1DM

insulin aspart target

insulin receptor

insulin aspart target family and location

receptor tyrosine kinase expressed on the surface of muscle, adipose and liver cells

insulin aspart pharmacologic activity

agonist

insulin lispro brand

Humalog

insulin lispro class

insulin, rapid-acting

insulin lispro indication

T1DM

insulin lispro target

insulin receptor

insulin lispro target family and location

receptor tyrosine kinase expressed on the surface of muscle, adipose and liver cells

insulin lispro pharmacologic activity

agonist

insulin glargine brand

Lantus

insulin glargine class

long-acting insulin

insulin glargine indication

T1DM

insulin glargine target

insulin receptor

insulin glargine target family and location

receptor tyrosine kinase expressed on the surface of muscle, adipose and liver cells

insulin glargine pharmacologic activity

agonist

liraglutide brand

Victoza, Saxenda

liraglutide class

antidiabetic agent, glucagon-like peptide-1 receptor agonist

liraglutide indication

T2DM, chronic weight management

liraglutide target

GLP-1 receptor

liraglutide target family and location

GPCR on pancreatic beta cells

liraglutide pharmacologic activity

agonist

exenatide brand

Byetta, Bydureon

exenatide class

antidiabetic agent, glucagon-like peptide-1 receptor agonist

exenatide indication

T2DM

exenatide target

GLP-1 receptor

exenatide target family and location

GPCR on pancreatic beta cells

exenatide pharmacologic activity

agonist

sitagliptin brand

Januvia

sitagliptin class

antidiabetic agent, DPP-4

sitagliptin indication

T2DM

sitagliptin target

DPP-4

sitagliptin target family and location

homodimeric peptidase on the surface of most cell types

sitagliptin pharmacologic activity

reversible, competitive inhibitor

pioglitazone brand

Actos

pioglitazone drug class

antidiabetic agent; thiazolidinedione

pioglitazone indication

T2DM

pioglitazone target

PPAR gama

pioglitazone target family and location

heterodimeric nuclear receptor in adipocytes

pioglitazone pharmacologic activity

agonist

glimepiride brand

Amaryl

glimepiride class

antidiabetic agent, sulfonylurea

glimepiride indication

T2DM

glimepiride target

ATP-sensitive K+ channel

glimepiride target family and location

ion channel expressed on pancreatic beta cells

glimepiride pharmacologic activity

reversible, allosteric blocker

glyburide brand

Diabeta, Glynase

glyburide class

antidiabetic agent, sulfonylurea

glyburide indication

T2DM

glyburide target

ATP sensitive K+ channel

glyburide target family and location

ion channel expressed on pancreatic beta cells

glyburide pharmacologic activity

reversible, allosteric blocker

glipizide brand

Glucotrol, Glucotrol XL

glipizide drug class

antidiabetic agent, sulfonylurea

glipizide indication

T2DM

glipizide target

ATP sensitive K+ channel

glipizide target family and location

ion channel expressed on pancreatic beta cells

glipizide pharmacologic activity

reversible, allosteric blocker

canagliflozin brand

Invokana

canagliflozin drug class

antidiabetic agent, SGLT2

canagliflozin indication

T2DM

canagliflozin target

SGLT2

canagliflozin target family and location

transporter expressed on epithelical cells of the proximal tubule in the nephron

canagliflozin pharmacologic activity

reversible inhibitor

metformin brand

Glucophage, Glumetza, Riomet

metformin class

antidiabetic agent, biguanide

metformin indication

T2DM

metformin target

AMPK

metformin target family and location

heterotrimeric kinase expressed in cells

metformin pharmacologic activity

activator

heparin brand

heparin class

anticoagulant

heparin indication

coagulation disorder

heparin target

antithrombin III

heparin target family and location

glycoprotein located in plasma

heparin pharmacologic activity

activator

enoxaparin brand

Lovenox

enoxaparin class

anticoagulant; anticoagulant, LMWH

enoxaparin indication

anticoagulation: ACS, DVT, venous thromboembolism, phophylaxis

enoxaparin target

antithombin III

enoxaparin target family and location

glycoprotein located in plasma

enoxaparin pharmacologic activity

activator

apixaban brand

Eliquis

apixaban class

anticoagulant; anticoagulant, factor Xa Inhibitor; DOAC

apixaban indication

anticoagulation:: DVT, Nonvalvular atrial fibrillation, post-op venous thromboprophylaxis following hip or knee replacement surgery, PE

apixaban target

factor Xa

apixaban target family and location

lydrolase enzyme in plasma

apixaban pharmacologic activity

reversible inhibitor

dabigatran brand

Pradaxa

dabigatran class

anticoagulant; direct thrombin inhibitor; DOAC

dabigatran indication

anticoagulation; DVT and PE treatment prevention, nonvalvular atrial fibrillaiton, and venous thromboembolism phorphylaxis in tota hip arthroplasty