Misc Flashcards
(28 cards)
What drugs can worsen glycaemic control in diabetes
Thiazides, furosemide, steroids, tacrolimus, ciclosporin, interferon-alpha, nicotinic acid, antipsychotics, beta-blockers
What drugs aggregate urinary retention
TCAs, anticholinerics, opioids, NSAIDs, disopyramide
What drugs can aggregate psoriasis
Lithium, ACEI, betablockers, alcohol, anti-malarials NSAIDs, infliximab
What drugs can cause hepatotoxicity
Sulfonylureas, sodium valproate, amiodarone, rifampicin, pioglitazone, methotrexate, isoniazid, phenytoin, ciclosporin
What drugs are safe for breastfeeding
TCAs, heparin, levothyroxine, warfarin, b-blockers, carbmazepine, trimethoprim, antipsychotics, glucocorticoids, theophyllines, penicillins, cephalosporins, hydralazine
What drugs are NOT safe for breastfeeding?
Tetracyclines, lithium, aspirin, methotrexate, amiodarone, sulphonamides, sulphonylureas, ciprofloxacin, benzos, carbimazole
Severe SE of nitrofurantoin
Pulmonary fibrosis
What drug can cause gout?
Pyrazinamide
What drug can cause optic neuritis
Ethambutol
What drug can cause nystagmus
Phenytoin
What drugs can cause constipation?
Opioids, antipsychotics, verapamil, TCAs
SE of dry mouth
Amitriptyline
What drugs can exacerbate HF
Thiazolidinedions, verapamil, NSAIDs, glucocorticoids, flecainide
Drugs caution in asthmatics
NSAIDs, b-blockers, adenosine
What two drugs should not be prescribed together due to risk of life-threatening bradycardias
b-blockers & verapamil
Drugs which can cause SIADH
Sulphonulureas, SSRIs, TCAs, carbamazepine, vincristine, cyclophosphamide
side effects of glucocorticoids
Endo: impaired glucose regulation, increased appetite / weight gain, hirsutism, hyperlipidaemia
Cushing’s syndrome: moon face, buffalo hump, striae
MSK: OP, proximal myopathy, avascular necrosis of the femoral head
Immunosuppression: increased susceptibility to severe infection, reactivation of tuberculosis
Psychiatric: insomnia, mania, depression, psychosis
GI: peptic ulcers, acute pancreatitis
Ophthalmic: glaucoma, cataracts
Suppression of growth in children, intracranial hypertension, neutrophilia
What drugs can cause constiptation
Antimuscarinics: hyoscine, oxybutynin, tolterodine, TCAs, anti-psychotics
Iron salts, calcium and aluminium salts
Verapamil
Opioids
P450 induces (increase INR)
AEDs: phenytoin, carbamazepine
Phenobarbitone
Rifampicin
St John’s wort
Chronic alcohol intake
Smoking
P450 inhibitors (decrease INR)
Abx: ciprofloxacin, erythromycin
Antifungals: fluconazole, imidazole, ketoconazole
Antiretrovirals: ritonavir
SSRIs: fluoxetine, sertraline
Isonazid
Cimetidine, omeprazole
Amiodarone
Allopurinol
Sodium valproate
Acute alcohol intake
Quinupristin
Tamoxifen
Grapefruit juice
Drugs which can prolong the QT interval
Amiodarone
Anti-psychotics
Quinolones
Macrolides
SSRIs
TCAs
Quinine
Haloperidol
Ondansetron
Drugs causing hypokalaemia
Insulin
Salbutamol
Loop diuretics
Drugs causing hyperkalaemia
ACEIs / ARBs
Aldosterone antagonists (spironolactone)
K+ sparing diuretics
KCl fluids
SE and CI of gentamycin
SE ototoxicity
CI in myasthenia gravis
