Misc

Question 1

Not a MAB

Answer 1

Etanercept (its a TNF alpha receptor)
Certrolizumab pegol (FC fragment replaced by PEG molecules)
Pegaptanib

Question 2

Contraindicated with TNF blocker or BRM (risk of infection)

Answer 2

Anakinra

Abatacept

Question 3

Lyses cells with TNF alpha receptors

Answer 3

Adalixumab

Question 4

Does not lyse cells with TNF alpha receptors

Answer 4

Certrolizumab pegol

Golimumab

Question 5

Adjuncts

Answer 5

For RA:
NSAID
Corticosteroids
Tetracyclines
Sulfasalazine (with MTX)
Hydroxychloroquine (with MTX)
Infliximab (with MTX)
Ritaximab (with MTX)

For Transplants:
MMF (with Prednisone)

Question 6

Pro-drugs

Answer 6

Micophenolate Mofetil (MMF) --> Mycophenolic Acid (MPA)
Leflunomide

Question 7

Given when MTX and DMARDs fail in RA

Answer 7

Tofacitinib

Question 8

Pyrimidine blockers

Answer 8

Leflunomide

Question 9

Purine blockers

Answer 9

Mycophenolic Acid (MPA)
Azathioprine

Question 10

Blocks everything: purines, pyrimidines, adenosine, cytokines

Answer 10

MTX

Question 11

Don’t combine with MTX because both block pyrimidines

Answer 11

Leflunomide

Question 12

3 major pro-inflammatory cytokines of RA

Answer 12

IL-1
IL-6
TNF-alpha

Question 13

Never combine biologics. However they can be combined with

Answer 13

MTX
Lefluromide
Azathioprine

Question 14

Calcineurin inhibitors (leads to blockade of IL-2)

Answer 14

Cyclosporine

Tacrolimus

Question 15

3 most important immunosuppressants used in organ transplantation and GVHD

Answer 15

Cyclosporine
Tacrolimus
Sirolimus

Question 16

Does not prevent GVHD

Answer 16

Cyclophosphamide

Question 17

Treatment of steroid resistant rejection

Answer 17

ATG

ALG

Question 18

Blocks killing of cytotoxic T-Cells

Answer 18

Muromonab

Question 19

Faster and longer term improvement than anti-TNF drugs

Answer 19

Ustekinumab