MISC. REWIEW QUESTIONS Flashcards

(41 cards)

1
Q

STAGES OF ALCOHOL WITHDRAWAL

A

alcohol withdrawal stages

Stage 1 (mild): anxiety, insomnia, nausea, abdominal pain and/or vomiting, loss of appetite, fatigue, tremors, depression, foggy thinking, mood swings, and heart palpitations

Stage 2 (moderate): increased blood pressure, body temperature and respiration, irregular heart rate, mental confusion, sweating, irritability, and heightened mood disturbances

Stage 3 (severe/delirium tremens): hallucinations, fever, seizures, severe confusion, and agitation

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2
Q

time line of alcohol withdrawal symptoms

A

Roughly 8 hours after first drink: The first stage withdrawal symptoms may begin.

After 24-72 hours: Symptoms generally peak in this time period, and stage 2 and 3 symptoms can rapidly manifest.

5-7 days later: Symptoms may start to taper off and decrease in intensity.
Beyond the first week: Some side effects, particularly the psychological ones, may continue for several weeks without treatment.

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3
Q

drugs approved for treatment of PTSD

A

–sertraline

–paroxetine

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4
Q

symptoms of withdrawal from heavy marijuana use

A
–irritability
–Drug craving
–Sleep disturbance
–Concentration problems
–depressed mood
–Diarrhea
–Nausea
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5
Q

symptoms of marijuana intoxication

A
–distorted perception
–increased appetite
–Euphoria
–Hallucinations
–injected sclera
–Increased heart rate
–Decreased blood pressure
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6
Q

drug most likely causing symptoms resolving with hot bath

A

cannabis

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7
Q

where is the brains reward system?

A

nucleus accumbens

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8
Q

clinical difference between cocaine intoxication and bipolar mania

A

–mania must last for week or more
–Hypomania last 4 or more days and is milder
–Cocaine symptoms are intermittent

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9
Q

volume of distribution of nicotine

A

180 L

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10
Q

R their racial differences in nicotine absorption and accumulations

A

–African-Americans absorbed 30% more nicotine think Caucasians
–Chinese Americans have lower nicotine levels
–Women nicotine faster than men

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11
Q

age group with the highest use of inhalants

A

young adults 18–25

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12
Q

what is precontemplation

A

–not yet considering change
–Resistance to change
–needs coalition to show up for change

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13
Q

what is contemplation

A

–ambivalence
–vacillation
–Wants to change but resist needed changes

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14
Q

what is preparation

A

–begin needed steps

–Increased confidence in decision to quit

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15
Q

what is action

A

–actually begins needed steps
–Needs support
–Over actions to change environment or to quit

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16
Q

what is maintenance

A

–consolidation of gains
–Learning alternative coping mechanisms
–Learning the triggers of emotion precipitate abuse

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17
Q

what is relapse and recycling

A

–possible but not necessary
–avoiding being stuck
–Learning from mistakes

18
Q

what his termination

A

–ultimate stage

–Patient exits treatment without fear of relapse

19
Q

difference between neuroleptic malignant syndrome and serotonin syndrome

A

both have
–Confusion
–Hyperthermia
–Increased muscle tone

neuroleptic malignant syndrome
–Akinesia
–Mutism
–rigidity

Serotonin syndrome
–Rambling speech

20
Q

drugs causing erectile dysfunction
–During intoxication
–During withdrawal

A

opioids cause sexual dysfunction during both intoxication and withdrawal

cocaine and stimulants cause sexual dysfunction only during intoxication

21
Q

which Tri-Cyclic antidepressant is most appropriate for treating daytime pain

A

desipramine is the least sedating tryicyclic antidepressants

22
Q

first-line drugs for treatment of generalized anxiety disorder

A

–paroxetine
– escitalopram
–Sertraline
–venlafaxine

23
Q

FDA approved uses for duloxetine

A
–major depressive disorder
–Generalized anxiety disorder
–Diabetic neuropathy
–Fibromyalgia
–Chronic musculoskeletal pain
24
Q

methamphetamine effects on neurotransmitters

A

synaptic levels dopamine and norepinephrine and serotonin are increased with methamphetamine

25
CT or MRI evidence of alcoholic brain degeneration
atrophy of cerebellar vermis
26
most common drug used to alter cocaine
levamisole, a veterinary anti-helminth drug is found and 69% of cocaine in the United States. –It does not recorded as an adulterant on Street tests of purity of cocaine. it produces… – leukopenia –Positive autoimmune factors –Often with reticular purpuric lesions, particularly on the ears, but may be on the extremities
27
ASAM levels of care
Six dimensions: o Dimension I: Acute Intoxication/Withdrawal Potential o Dimension II: Biomedical Conditions and Complications o Dimension III: Emotional, Behavioral or Cognitive Conditions and Complications o Dimension IV: Readiness to Change o Dimension V: Relapse, Continued Use or Continued Problem Potential o Dimension VI: Recovery Environment • Five levels of care: o Level 0.5: Early Intervention o Level I: Outpatient Treatment o Level II: Intensive Outpatient/Partial Hospitalization o Level III: Residential/Inpatient Treatment o Level IV: Medically-Managed Intensive Inpatient Treatment
28
sub specifiers in ASAM levels of care
D = need for detoxification BIO = need for management of concurrent medical illness OMT = need for opioid maintenance therapy AOD = need for drug or substance use therapy only DDC and DDE= psychiatric dual diagnosis present
29
physician specialties with the most drug abuse
–psychiatry –Emergency physicians –Anesthesiologists
30
drug abuse patterns among physicians
–most common drug of abuse is alcohol –Cannabis is the most common illegal drug –Physician drug abuse mimics general population at 8-15%
31
mechanism of disulfiram
disulfiram irreversibly inhibits the oxidation of acetyl aldehyde by competing with the cofactor nicotinamide adenosine dinucleotide for binding sites on acetyl alcoholcetyl alcohol dehydrogenase causing a 5–10 time increase in acetalcohol causing the severe classic "hangover"
32
what area of the brain is involved in the reinforcement of drugs and alcohol?
the basal forebrain is involved in the reinforcement effects of drugs and alcohol. It consists of the "extended amygdala" which contains
33
bupropion mimics a psycho pharmacologic action of nicotine by increasing…
bupropion mimics the psychopharmacological action of nicotine by increasing dopamine and norepinephrine
34
what are the byproducts of metabolism of disulfiram which can be tested by breath analyzer?
disulfiram users will have carbon disulfide and acetone in there breath when tested by a breath analyzer
35
benzodiazepines work by attaching which receptor?
benzodiazepine attach to the GABA–a receptor
36
what is the test to determine the severity of nicotine addiction?
nicotine addiction severity is measured by the Fagerstrom test for nicotine dependence
37
mechanism of action of pregabalin and gabapentin
both pregabalin and gabapentin modulate calcium influx into neurons affecting nociception
38
how does sedative withdrawal cause hypertension?
sedative withdrawal causes hypertension by allowing a increase in norepinephrine and dopamine
39
mechanism of action of disulfiram for alcohol control
blocks dopamine beta hydroxylase in the brain
40
which receptor complex is involved in addiction to sedatives?
GABA a is a receptor complex involved in an addiction to sedatives. Acts by hyper polarizing cell membrane by increasing the intracellular chloride
41
mechanism of topiramate in the treatment of alcoholism
topiramate antagonizes glutamate and suppresses alcohol-induced dopamine release