Misc. Terminology Flashcards Preview

Immunology > Misc. Terminology > Flashcards

Flashcards in Misc. Terminology Deck (18):
1

Cytokines

Proteins that will alter the response of the immune system

2

Interferons

Antiviral activity, tumoricidal effects. Stimulate macrophages, T cells, B cells, and NK cells.

3

Alpha and B interferons

-Type 1
-Synthesized by macrophages, fibroblasts, and other cell types (T cells?)

4

Gamma interferon

-Produced by T cells that are stimulated.
-Stimulates macrophages
-Leads to differentiation of T cells and B cells

5

IL-1

-Made primarily by macrophages
-Stimulates T, B liver, bone, synovial, brain, and muscle cells

6

IL-2

-Produced by T cells
-T cell growth factor (formerly known as)
-Stimulates B cells and macrophages

7

IL-3

-Colony stimulating factor (CSF)
-Production of many different types of cells

8

IL-4

-B cell growth factor
-Important in T-cell stimulation of B-lymphocytes
-T cell growth factor
-Regulator of T cell function

9

IL-5

-B cell growth factor and differentiation factor
-Eosinophil growth factor

10

IL-6

-Principal mediator of the acute phase response of inflammation

11

IL-10

-Stimulates induction of TH-2 cytokines and may suppress TH1 cytokines

12

IL-12

-Stimulates TH1 response

13

IL-17

-Involved in inflammation

14

CSF-1

-Macrophage colony formation

15

GM-CSF

-Granulocyte and macrophage colonies

16

G-CSF

-Granulocyte colonies

17

Multi-CSF

-Growth of many different myeloid cells

18

TNF alpha or beta

-Involved in immunity to tumors and microorganisms
-Potent inflammatory effects
-Mediator of septic shock in humans--vascular damage and fever
-Product of activated macrophages, vascular smooth muscle cells, and some T cells.
-TNF-b is a product of T cells (lymphotoxin)