miscellaneous

Question 1

differentiate between the three types of MEN syndrome

Answer 1

MEN1 = 3Ps= AD:
Parathyroid hyperplasia
Pituitary adenoma and LOTS of other oma’s
Pancreatic islet cell tumour

MEN2A = 2Ps 1M = AD:
Parathyroid hyperplasia
Phaeochromocytoma
Medullary thyroid carcinoma
… and hirschprung

MEN2B = 1P 2 Ms
Marfanoid habitus + mucosal neuromas
Phaeochromocytoma
Medullary thyroid carcinoma

Question 2

differentiate between types of APS syndrome

Answer 2

T1 = APECED = ‘HAMP’ - AIRE:
Hypothyroidism
3. Addison’s
1. Mucocutaneous candidiasis
2. Parathyroid – hypo

T2 = HAD - adulthood
Hypothyroidism
Addison’s
Diabetes (T1DM)

T3 = TVAP:
Thyroiditis
Diabetes
Pernicious anaemia
Vitiligo