Miscellaneous endocrine and metabolic disorders

Question 1

Define multiple endocrine neoplasia (MEN)

Answer 1

Simultaneous or metachronous occurence of tumours involving a number of endocrine glands. Inherited in autosomal dominant pattern.

Question 2

What are the types of multiple endocrine neoplasia (MEN)?

Answer 2

MEN 1: Pancreatic, parathyroid, and pituitary tumours
MEN 2a: Parathyroid, phaeochromocytoma, medullary thyroid carcinoma
MEN 2b: Mucosal neuromas, marfanoid phenotype, phaeochromocytoma, medullary thyroid carcinoma

Question 3

How is multiple endocrine neoplasia (MEN) managed?

Answer 3

MEN 1: Four-gland parathyroidectomy recommended

Annual screening to detect tumours at an early, treatable stage.